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Human medicines European public assessment report (EPAR): Vaxchora, cholera vaccine, oral, live, Date of authorisation: 01/04/2020, Revision: 8, Status: Authorised

Retrieved on: 
Tuesday, January 2, 2024

Human medicines European public assessment report (EPAR): Vaxchora, cholera vaccine, oral, live, Date of authorisation: 01/04/2020, Revision: 8, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Vaxchora, cholera vaccine, oral, live, Date of authorisation: 01/04/2020, Revision: 8, Status: Authorised

Human medicines European public assessment report (EPAR): Moventig, naloxegol, Date of authorisation: 07/12/2014, Revision: 16, Status: Authorised

Retrieved on: 
Tuesday, January 2, 2024

Human medicines European public assessment report (EPAR): Moventig, naloxegol, Date of authorisation: 07/12/2014, Revision: 16, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Moventig, naloxegol, Date of authorisation: 07/12/2014, Revision: 16, Status: Authorised

Human medicines European public assessment report (EPAR): Nuvaxovid, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 20/12/2021, Revision: 11, Status: Authorised

Retrieved on: 
Tuesday, January 2, 2024

Human medicines European public assessment report (EPAR): Nuvaxovid, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 20/12/2021, Revision: 11, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Nuvaxovid, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 20/12/2021, Revision: 11, Status: Authorised

Human medicines European public assessment report (EPAR): Bimervax, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 30/03/2023, Revision: 3, Status: Authorised

Retrieved on: 
Tuesday, January 2, 2024

Human medicines European public assessment report (EPAR): Bimervax, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 30/03/2023, Revision: 3, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Bimervax, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 30/03/2023, Revision: 3, Status: Authorised

Human medicines European public assessment report (EPAR): Spikevax (previously COVID-19 Vaccine Moderna), COVID-19 mRNA vaccine,elasomeran,elasomeran / imelasomeran,elasomeran / davesomeran,andusomeran, Date of authorisation: 06/01/2021, Revision: 41[...]

Retrieved on: 
Tuesday, January 2, 2024

Human medicines European public assessment report (EPAR): Spikevax (previously COVID-19 Vaccine Moderna), COVID-19 mRNA vaccine,elasomeran,elasomeran / imelasomeran,elasomeran / davesomeran,andusomeran, Date of authorisation: 06/01/2021, Revision: 41, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Spikevax (previously COVID-19 Vaccine Moderna), COVID-19 mRNA vaccine,elasomeran,elasomeran / imelasomeran,elasomeran / davesomeran,andusomeran, Date of authorisation: 06/01/2021, Revision: 41, Status: Authorised

Magnets, mating and metallic objects – cautionary tales from the MRI scanner

Retrieved on: 
Saturday, December 30, 2023

She had attended the hospital for an MRI (magnetic resonance imaging) scan and had entered the machine with a concealed firearm.

Key Points: 
  • She had attended the hospital for an MRI (magnetic resonance imaging) scan and had entered the machine with a concealed firearm.
  • This isn’t the first time in 2023 that a firearm injury has been sustained in an MRI scanner.
  • In February a lawyer in Brazil died after the gun tucked in his waistband discharged into his abdomen.
  • MRI has a long history, in one form or another, dating back to the 1930s.

Strong magnets

  • One of the biggest risks with MRI comes from the incredibly strong magnets that are used because they are not selective in the objects they act on.
  • Also, newer models tend not to contain ferrous metals – that is, metals that can be attracted by magnets because they contain iron.
  • Similarly, a child suffered bowel perforation during an MRI after ingesting 11 small spherical magnets.

Outside the machine can be dangerous too

  • In 2018, an Indian man was killed when an oxygen cylinder he was carrying was pulled into the MRI machine, causing it to rupture and kill him.
  • Similarly, in 2021, a South Korean man died when an oxygen cylinder in the MRI room crushed his skull after the magnet pulled it into the machine he was being scanned in.

Benefits far outweigh the risks


Despite the above stories, MRI is a revolutionary diagnostic machine that has benefits that far outweigh the risks. Further modifications of MRI, such as fMRI (functional MRI), let doctors and researchers look at brain activity and observe how diseases, such as Alzheimer’s, are progressing. They are also helping researchers discover new drugs and study anatomy – including during sex and orgasm.
These revolutionary machines are extremely useful and are entirely safe when used correctly. So next time you have an MRI scan, when clinical staff ask what seems like innocent and straightforward questions, answer honestly. And tell them about anything you think may be relevant, no matter how trivial, just to be on the safe side.
Adam Taylor does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

How to make your life greener in 2024

Retrieved on: 
Saturday, December 30, 2023

The People’s Climate Vote, a UN survey of public opinion on climate change, highlights that citizens around the world recognise climate change as a global emergency and agree that we should do everything necessary in response.

Key Points: 
  • The People’s Climate Vote, a UN survey of public opinion on climate change, highlights that citizens around the world recognise climate change as a global emergency and agree that we should do everything necessary in response.
  • Read more:
    Eco-anxiety: climate change affects our mental health – here's how to cope

    So if you’re looking to make your life greener in 2024, here are some manageable and affordable changes you can make.

1. Eating

  • But there are simple changes you can make to eat more sustainably (and often at less expense too).
  • These include eating locally and seasonally, or eating less meat and more plants, especially beans and greens.
  • Eating processed “mock meats” can be a stepping stone towards a more plant-based lifestyle, although they are relatively expensive.

2. Travelling

  • Choosing active travel – walking, wheeling and cycling – is the greenest option, keeping us and our children fitter and healthier while producing no carbon emissions.
  • In urban areas, where you’re travelling shorter distances, active transport is often faster and cheaper than car travel.
  • For longer journeys, travelling by train or bus is more environmentally friendly than by car and plane.

3. Energy use

  • The energy we use at home is becoming increasingly expensive and is a significant contributor to greenhouse gas emissions.
  • Making small changes to our daily energy use can make a big difference, both to our bills and household emissions.
  • Using the data recorded by a smart meter (if you have one) to monitor your energy use can help you make these changes.

4. Clothing

  • You can even make your clothing more personal using repair methods such as Sashiko stitching, making the repair a visible feature of your clothing.
  • You could also swap clothing you no longer want with friends and family or at swap shops.
  • Alternatively, you could buy less, but higher quality clothing.

5. Waste management

  • We generate more than 2 billion metric tons of solid municipal waste worldwide each year.
  • There are many small changes we can make to reduce the amount we put in our bins.
  • Reducing waste saves valuable resources as well as reducing pollution and your weekly spend.


Ian Williams receives funding from EU Horizon 2020 and EPSRC. Ian Williams is a member of the International Solid Waste Association, the Chartered Institution of Wastes Management and the Royal Society of Chemistry. Alice Brock does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

'Foul and loathsome’ or jewels of the natural world? The complicated history of human-frog relations

Retrieved on: 
Saturday, December 30, 2023

Perhaps you came across one in your garden and wondered at its little hands, glossy skin and what looked very much like a contented smile.

Key Points: 
  • Perhaps you came across one in your garden and wondered at its little hands, glossy skin and what looked very much like a contented smile.
  • As our research has found, the history of human-frog relations is long and complicated – and not all of it is nice.

Why we love frogs

  • There is a rich history of people really loving frogs.
  • This is interesting, because many people much prefer mammals and birds over reptiles and amphibians.
  • Frogs are truly among the jewels of the natural world, unlike toads which – with their more mundane colours and “warty skins” – do not usually inspire the same sense of enchantment.

Dissecting human feelings for frogs


Yet relationships between people and frogs haven’t always been so positive. In fact, frogs occupy complicated places across cultures all over the world. In the Western tradition, the legacy of biblical and classical sources was both negative and longstanding. References to frogs in the Bible rendered them the instrument of divine anger as a swarming plague.

  • Frogs challenged early modern zoological taxonomies, moving between classification as serpent, insect or reptile.
  • In modern science, they sit in a branch of zoology, herpetology, that brings frogs together as “creeping animals” with snakes and lizards.
  • Italian scientist Luigi Galvani, for example, did experiments in the late 18th century on legs of frogs to investigate what he thought of as “animal electricity”.
  • In time, experiments with frogs moved beyond the laboratory into the classroom.
  • In the 1930s, schoolchildren were expected to find frogs and bring them to school for dissection in biology classes.

Recognising the fragility of frogs

  • From the frogs of Aesop’s Fables to the meme Pepe the Frog, we have projected our own feelings and frustrations onto frogs, and exploited them for science and education.
  • Frogs have also borne the brunt of our failures as environmental stewards.
  • In 2022, over 40% of amphibian species (of which frogs and toads are by far the largest group) were threatened with extinction.


Susan Broomhall receives funding from the Australian Research Council. Andrea Gaynor receives funding from the Australian Research Council. Andy Flack does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

A brief history of time – as told by a watchmaker

Retrieved on: 
Saturday, December 30, 2023

Then they garbled on about the philosophical nature of time, still resisting payment.

Key Points: 
  • Then they garbled on about the philosophical nature of time, still resisting payment.
  • It was during that wistful, skyward narrative that I saw the timepiece slip from their hand and hit the marble floor.
  • Time was important enough to our ancestors that they went to the effort of building an extraordinary prehistoric monument, Stonehenge.

It’s in the timing

  • The Sumerians (4100-1750BC) based around Mesopotamia (modern-day Iraq) calculated that the day was approximately 24 hours and that each hour was 60 minutes long.
  • Water clocks used the gradual flow of water from one container to another to measure time.
  • But the length of these “hours” varied depending on the time of year – longer in summertime than winter.
  • These measures of time were based on the Sun, with 12 parts during daylight, and another 12 parts through the night.
  • The time period between these canonical prayers became equal in length because of the rigidity of prayer times.

Prayer time


While we can’t be certain from historical records if it was monks who made the first mechanical clocks, we do know that they first appeared in the 14th century. Their first mention is in the Italian physician, astronomer and mechanical engineer Giovanni de Dondi’s treatise Tractatus Astrarii, or Planetarium. De Dondi states that early clocks used gravity as their power source and were driven by weights.

  • These early clocks started popping up in city centres but, since they did not have a face, they used bells to signal the hours.
  • These signals began to organise the market times and administrative needs of each city.
  • Coiled springs as a method of releasing energy for clocks began to appear in Europe in the 15th century.

Time tracking in other parts of the world

  • And long before that, the Ancient Greek Antikythera mechanism, regarded as the world’s first computer, is dated at around 100BC (having been discovered in AD1901).
  • Meanwhile in China, there was Su Song’s astronomical clock – dated to AD1088 – which was powered by water.
  • Today, wherever we are in the world, time is a unified construct – and the search for ever-more precise measurements continues.


Jaq Prendergast does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Six ways to look after your eyes in 2024

Retrieved on: 
Saturday, December 30, 2023

The World Health Organization estimates that over 80% of all vision impairment around the world can be prevented and even cured. Reducing the risk of eye diseases involves adopting a combination of lifestyle changes, protective measures, and regular eye care. Here are six ways to look after your eyes in 2024. 1. Have regular eye testsGlaucoma, for example, will cause irreversible damage to the eye if not picked up early enough as it damages the peripheral visual field to start with.

Key Points: 


The World Health Organization estimates that over 80% of all vision impairment around the world can be prevented and even cured. Reducing the risk of eye diseases involves adopting a combination of lifestyle changes, protective measures, and regular eye care. Here are six ways to look after your eyes in 2024.

1. Have regular eye tests

  • Glaucoma, for example, will cause irreversible damage to the eye if not picked up early enough as it damages the peripheral visual field to start with.
  • Eye disease linked to diabetes also causes irreversible damage to the eyes without much noticeable vision loss as it damages the small blood vessels in the eye.
  • Going for an eye test with a qualified optometrist will enable them to detect eye diseases and refer you to a specialist if needed.

2. Check your eyes at home

  • As most of us use both eyes at the same time, it can be difficult to know if one is not seeing so well.
  • Try covering each eye every week and look at a number plate in the distance to make sure both eyes are seeing well.

3. Protect your eyes from mechanical and UV damage

  • Make sure you wear good quality sunglasses that block 100% of UVA and UVB rays to protect your eyes from harmful ultraviolet radiation.
  • In the summer, gardening accidents, such as getting caught in the eye with a twig when pruning are quite frequent and can cause permanent damage.

4. Reduce digital eye strain

  • While eyestrain does not normally cause permanent damage or affect your glasses prescription, it can be very uncomfortable.
  • Most people forget to blink when they are working on screens, and this leads to dry eyes.
  • To reduce this discomfort, try consciously blinking more often during screen time.

5. Have a good diet

  • While many of us know that vitamin A from carrots is good for the eyes, our eyes need more than vitamin A to function healthily.
  • A healthy diet is also linked to good control of diabetes, and poor control of diabetes will lead to a much higher risk of blindness from diabetic-related eye disease.

6. Quit smoking and be more active

  • Smoking is a significant risk factor for most systemic diseases in the body including the eyes.
  • Smoking increases the risk of macular degeneration and cataracts.
  • Exercise is not only important for the rest of the body but also for the eyes.


[email protected] receives funding from various NHS bodies, Charities and EU.