Disease

Philadelphia Court Upholds $816M Verdict Against ExxonMobil in Benzene Cancer Case

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Friday, September 13, 2024

PHILADELPHIA, Sept. 13, 2024 /PRNewswire/ -- A Philadelphia jury's $725.5 Million verdict against ExxonMobil in a benzene case has been upheld by the Philadelphia Court of Common Pleas. The Court denied all of ExxonMobil's post-trial motions and added over $90 million in delay damages, to bring the total award to just under $816 Million. The verdict, which was obtained by Andrew DuPont of Locks Law Firm and Patrick Wigle and Rajeev Mittal of Waters Krause Paul & Siegel on behalf of Paul Gill and his wife Diane Gill, is a major victory for the plaintiffs and a significant setback for ExxonMobil.

Key Points: 
  • PHILADELPHIA, Sept. 13, 2024 /PRNewswire/ -- A Philadelphia jury's $725.5 Million verdict against ExxonMobil in a benzene case has been upheld by the Philadelphia Court of Common Pleas.
  • The case stemmed from Mr. Gill's exposure to benzene contained in Mobil Oil gasoline when he worked as a mechanic and gasoline station attendant between 1974 and 1979.
  • ExxonMobil filed several motions following the verdict which sought to overturn or reduce the jury's verdict.
  • Mr. and Mrs. Gills' verdict was the largest ever in a benzene case.

Agriculture Sensing and Monitoring Devices Market to Grow by USD 620.7 Million (2024-2028), Rising Population Drives Food Demand, AI Transforming Market - Technavio Report

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Friday, September 13, 2024

These innovations underscore the progress in agriculture sensing technologies, enabling farmers to manage resources efficiently and sustainably, fueling the expansion of the global agriculture sensing and monitoring devices market.

Key Points: 
  • These innovations underscore the progress in agriculture sensing technologies, enabling farmers to manage resources efficiently and sustainably, fueling the expansion of the global agriculture sensing and monitoring devices market.
  • (Exact word count: 50)
    Agriculture sensing and monitoring devices are transforming modern farming practices.
  • The global agriculture sensing and monitoring devices market faces a significant challenge due to the high initial costs associated with adopting these technologies.
  • Overall, agriculture sensing and monitoring devices are crucial for optimum production, productivity, and crop yield in the face of food demand, arable land, and various environmental pressures.

FDA Approves Ocrevus Zunovo™ as the First and Only Twice-a-Year 10-Minute Subcutaneous Injection for People With Relapsing and Progressive Multiple Sclerosis

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Friday, September 13, 2024

Ocrevus Zunovo is the first and only twice-a-year, healthcare professional (HCP)-administered approximately 10-minute subcutaneous (SC) injection approved for both these forms of multiple sclerosis, giving people living with MS more treatment options.

Key Points: 
  • Ocrevus Zunovo is the first and only twice-a-year, healthcare professional (HCP)-administered approximately 10-minute subcutaneous (SC) injection approved for both these forms of multiple sclerosis, giving people living with MS more treatment options.
  • Injection reactions were more frequently reported with the first injection, with 49% of trial participants experiencing an injection reaction after the first injection.
  • Genentech has more than 30 ongoing multiple sclerosis clinical trials designed to help us better understand the disease and its progression.
  • With Ocrevus Zunovo and Roche and Genentech’s 14 subcutaneous therapies – available across various diseases – we offer additional administration options to meet the diverse preferences of patients.

CaringKind Presents the 8th Annual Caring to Remember benefit: Raising Awareness and Funds for Alzheimer's and Related Dementias

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Friday, September 13, 2024

NEW YORK, Sept. 13, 2024 /PRNewswire/ -- CaringKind, New York City's leading expert in Alzheimer's and related dementia caregiving, is proud to announce the 8th Annual Caring to Remember Cocktail benefit, which will take place on Wednesday, September 18, 2024, at Tribeca 360. This prestigious event will bring together more than 500 influential leaders from New York City's real estate and construction industries for an evening of networking, celebration, and raising crucial funds and awareness to support those impacted by Alzheimer's disease and related dementias.

Key Points: 
  • This prestigious event will bring together more than 500 influential leaders from New York City's real estate and construction industries for an evening of networking, celebration, and raising crucial funds and awareness to support those impacted by Alzheimer's disease and related dementias.
  • Since its inception, the event has raised over $1.5 million to support groundbreaking research, caregiving services, and advocacy efforts.
  • In honor of World Alzheimer's Day on September 21, CaringKind is partnering with prominent New York City landmarks to light the skyline in purple.
  • On the evening of September 18, the following buildings will illuminate in purple to show solidarity with those affected by Alzheimer's and related dementias:

Prelude Therapeutics’ SMARCA2 Degrader PRT3789 Demonstrated Promising Initial Clinical Activity and Safety Profile in Phase 1 Trial

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Friday, September 13, 2024

WILMINGTON, Del., Sept. 13, 2024 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (Nasdaq: PRLD), a clinical-stage precision oncology company, today announced the first interim clinical data from its ongoing Phase 1 open-label, dose-escalation trial of PRT3789, a first-in-class SMARCA2 degrader, highly selective for SMARCA2 and designed to treat cancer patients with a SMARCA4 mutation. The data were presented at the European Society for Medical Oncology (ESMO) Congress 2024 in Barcelona, Spain.

Key Points: 
  • Additional patients demonstrated clinical benefit as measured by prolonged stable disease (SD) including one patient on treatment for more than 1 year.
  • “The observation of durable stable disease and tumor regressions in Phase I monotherapy dose escalation, coupled with a tolerable emerging safety profile, is encouraging.
  • Evaluation of the AUC of PD (SMARCA2 and SMARCA4) demonstrated a dose dependent decrease of SMARCA2 but not SMARCA4, demonstrating the high selectivity of PRT3789.
  • The presentation titled, “First Clinical Results from a Phase 1 Trial of PRT3789, a First-in-Class SMARCA2 Degrader, in Patients with Advanced Solid Tumors with a SMARCA4 Mutation,” will be presented by Timothy Yap, M.D.

ENHERTU® Showed Substantial Clinical Activity in Patients with HER2 Positive Metastatic Breast Cancer and Brain Metastases

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Friday, September 13, 2024

Results from the DESTINY-Breast12 phase 3b/4 trial showed that ENHERTU® (trastuzumab deruxtecan) demonstrated substantial overall and intracranial clinical activity in a large cohort of patients with HER2 positive metastatic breast cancer who have brain metastases and received no more than two prior lines of therapy in the metastatic setting.

Key Points: 
  • Results from the DESTINY-Breast12 phase 3b/4 trial showed that ENHERTU® (trastuzumab deruxtecan) demonstrated substantial overall and intracranial clinical activity in a large cohort of patients with HER2 positive metastatic breast cancer who have brain metastases and received no more than two prior lines of therapy in the metastatic setting.
  • An additional endpoint analysis of CNS ORR in patients with brain metastases at baseline showed ENHERTU demonstrated a CNS ORR of 62.3% (95% CI: 50.1-74.5; n=38/61) in patients with active brain metastases and 79.2% (95% CI: 70.2-88.3; n=61/77) in patients with stable brain metastases.
  • A post-hoc analysis in patients with active brain metastases showed the CNS ORR was 82.6% (95% CI: 67.1-98.1; n=19/23) in untreated patients and 50.0% (95% CI: 34.1-65.9; n=19/38) in patients with treated/progressing brain metastases.
  • The most common grade 3 or higher adverse events occurring in 5% or more of patients in either cohort included neutropenia (16% in brain metastases and 18% in non-brain metastases), fatigue (9% in brain metastases and 10% in non-brain metastases), anemia (7% in brain metastases and 5% in non-brain metastases) and nausea (5% in brain metastases and 5% in non-brain metastases).

AMGEN TO PRESENT DATA FROM MULTIPLE EARLY-STAGE CLINICAL TRIALS AT ESMO 2024

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Friday, September 13, 2024

THOUSAND OAKS, Calif., Sept. 13, 2024 /PRNewswire/ -- Amgen (NASDAQ: AMGN) today announced the presentation of new data across its broad oncology pipeline and portfolio at the European Society for Medical Oncology (ESMO) Congress 2024, taking place Sept. 13-17 in Barcelona. The abstracts showcase data from Amgen-sponsored and investigator-sponsored studies for colorectal, lung, prostate and gastric cancers using molecularly targeted modalities.  

Key Points: 
  • The abstracts showcase data from Amgen-sponsored and investigator-sponsored studies for colorectal, lung, prostate and gastric cancers using molecularly targeted modalities.
  • "The breadth of these data reflects our strategy to advance diverse modalities for difficult-to-treat cancers," said Jay Bradner, M.D., executive vice president, Research and Development, and chief scientific officer at Amgen.
  • "These ESMO results underscore our leadership in oncology, contributing significant advancements with both investigational and established therapies.
  • Phase 1 dose escalation and initial dose expansion data from AMG 193 selected for a presidential symposium session.

Voters’ ‘moral flexibility’ helps them defend politicians’ misinformation − if they believe the inaccurate info speaks to a larger truth

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Friday, September 13, 2024

Many voters are willing to accept misinformation from political leaders – even when they know it’s factually inaccurate.

Key Points: 
  • Many voters are willing to accept misinformation from political leaders – even when they know it’s factually inaccurate.
  • According to our research, voters often recognize when their parties’ claims are not based on objective evidence.
  • Yet they still respond positively, if they believe these inaccurate statements evoke a deeper, more important “truth.” Our team conducted a series of online surveys from 2018 to 2023 with over 3,900 American voters.
  • These surveys were designed to elicit responses about how they evaluated political statements from several politicians, even when they recognized those statements as factually inaccurate.

Why it matters

  • However, our discovery illustrates the deeper but overlooked drivers behind voters’ tolerance and support for factually inaccurate statements.
  • The findings suggest that misinformation survives not only due to voters’ “gullibility” but their moral calculations about whether partisan ends justify the means.

What still isn’t known

  • Our research leaves critical questions about how to combat such moral flexibility and its consequences.
  • To be sure, we do not see such moral flexibility as categorically wrong.

What’s next

INmune Bio Announces $13.0 Million Registered Direct Offering

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Friday, September 13, 2024

The gross proceeds of the offering will be approximately $13.0 million before deducting placement agent fees and other estimated offering expenses.

Key Points: 
  • The gross proceeds of the offering will be approximately $13.0 million before deducting placement agent fees and other estimated offering expenses.
  • The closing of the offering is expected to take place on or about September 16, 2024, subject to the satisfaction of customary closing conditions.
  • The Company intends to use the net proceeds from the offering for working capital and general corporate purposes.
  • This offering is being made pursuant to an effective shelf registration statement on Form S-3 (File No.

Ascendis to Present First Results from Platinum-Resistant Ovarian Cancer (PROC) Cohort of the Phase 1/2 IL-Believe Trial at ESMO 2024

Retrieved on: 
Friday, September 13, 2024

COPENHAGEN, Denmark, Sept. 13, 2024 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (Nasdaq: ASND) today announced initial data showing signs of clinical activity in heavily pre-treated patients with platinum-resistant ovarian cancer (PROC) treated with TransCon IL-2 β/γ in combination with chemotherapy in its ongoing Phase 1/2 IL-Believe Trial of TransCon IL-2 β/γ. First results will be shared in Poster 762P at ESMO 2024, the annual meeting of the European Society of Medical Oncology being held in Barcelona from September 13-17, 2024.

Key Points: 
  • First results will be shared in Poster 762P at ESMO 2024, the annual meeting of the European Society of Medical Oncology being held in Barcelona from September 13-17, 2024.
  • The data suggest that TransCon IL-2 β/γ was generally well-tolerated: the most common treatment-emergent adverse events related to combination therapy with TransCon IL-2 β/γ plus chemotherapy were fatigue, thrombocytopenia, neutropenia, and anemia.
  • Most TransCon IL-2 β/γ-related TEAEs were grade 1 or 2.
  • “We look forward to providing further updates as patients continue on study treatment.”