Cell

• I believe this pervasive variation, which I call poikilosis, is one of the most important aspects of biology.
• Yet it doesn’t receive anywhere near enough attention from scientists and doctors – or worse, it is treated as unwanted noise in experiments and studies.
• But if scientists were to take much greater account of variation it could lead to new ways of understanding biological systems, and perhaps new ways to treat disease.
• However, research has shown that when variation in animals used in studies is taken into account, that increases the reproducibility of research.
• But measurements that account for poikilosis typically demand for higher number of experiments than traditionally made.

Lagom, natural state

• We can use the term “lagom”, a Swedish concept for just the right amount – not too much or too little – to refer to the natural, balanced state of any system required for it to function normally.
• When one level enters a non-lagom state, it can affect several other levels, potentially causing damage or impairing the functionality of the system or individual.
• If it rises to unusually high and harmful levels it enters a non-lagom state.
• For example, I have developed a model for “biological regulation” (active alteration of the state of a biological system) known as the PLTR model.

• FUJIFILM Cellular Dynamics will present iCell Sensory Neurons and other key products in its market-leading neuroscience portfolio at the Society for Neuroscience annual conference in Chicago (booth #464) from October 5-9, 2024 and the Annual Pain Therapeutics Summit in Boston from October 28-29, 2024.
• Sensory neurons that innervate the skin and internal organs are responsible for relaying sensory information to the central nervous system, including noxious/painful stimuli.
• The use of highly relevant human neurons promises to significantly improve drug predictability compared to animal models, and provide investigators with better models to improve pain research outcomes.
• To learn more about FUJIFILM Cellular Dynamics’ iCell Sensory Neurons, visit our website using the specific link: https://www.fujifilmcdi.com/sensory_neurons
  FUJIFILM Cellular Dynamics will present two posters featuring iCell Sensory Neurons at the upcoming Society for Neuroscience 2024 annual conference:

• StoreDot's battery addresses the main barrier to mass EV adoption by eliminating charging anxiety and is available for immediate integration by OEMs.
• Despite halving the charging time compared to other premium fast-charging models, StoreDot's batteries uniquely show no accelerated degradation due to fast charge.
• "Together, we've taken a giant leap forward in EV battery innovation, offering OEMs our game-changing XFC technology in the prismatic format many prefer.
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• From the moment food touches your tongue to the time it leaves your body, your digestive system and gut microbiome work to extract its nutrients.
• Enzymes in your mouth, stomach and small intestine break down food for absorption, while microbes in your large intestine digest the leftovers.
• “Calories in, calories out” refers to the concept that weight change is determined by the balance between the calories you consume and calories you expend.

Ruminating on appetite and digestion

• Fiber and polyphenols also help regulate your appetite and calorie intake through the brain.
• Your microbiome transforms these leftover bioactives into metabolites – molecular byproducts of digestion – that naturally decrease your appetite.

Mitochondrial maestros in the middle

• Healthy people typically have high-capacity mitochondria that easily process calories to fuel cellular functions.
• People with metabolic diseases have mitochondria that don’t work as well, contributing to bigger appetites, less muscle and increased fat storage.
• Your mitochondrial health is ultimately influenced by many factors, including those usually associated with overall well-being: regular exercise, adequate sleep, stress management and healthy eating.

Who turned off the metabo-lights

• Many bioactives pass undigested through the small intestine to the large intestine, where the microbiome converts them into activated metabolites.
• When the metabolic “lights” are turned on, they enliven the mitochondria responsible for a faster metabolism, effectively increasing the calories you use.

Please mind the microbiome gap

• Overuse of antibiotics, high stress and lack of exercise can also adversely affect microbiome and mitochondrial health.
• This creates a double nutrition gap: a lack of healthy diet and a deficiency in the microbes to convert its bioactives.
• Emerging microbiome-targeting approaches might also prove helpful for improving your metabolic health: butyrate and other postbiotics to provide preformed microbiome metabolites, personalized nutrition to tailor your diet to your microbiome, intermittent fasting to help repair your microbiome, and the future possibility of live bacterial therapies to restore microbiome health.

Tools to transform fat into fuel