Tablet

Hard work and happy accidents: why do so many of us prefer ‘difficult’ analogue technology?

Retrieved on: 
Thursday, April 18, 2024

Up two flights of stairs, the music machinery on offer includes brands such as Moog and Buchla, as well as modern euro-racks.

Key Points: 
  • Up two flights of stairs, the music machinery on offer includes brands such as Moog and Buchla, as well as modern euro-racks.
  • (From Michael’s fieldnotes)
    I finally locate the legendary Schneiders Buero, a shop selling analogue synthesizers in Berlin’s Kotti neighbourhood.
  • Up two flights of stairs, the music machinery on offer includes brands such as Moog and Buchla, as well as modern euro-racks.
  • (From Michael’s fieldnotes) As academics who rarely go a day without playing or making music, we have spent the past decade examining the extraordinary revival of analogue technology.
  • This means there are now more analogue options available than at any time since the 1970s, the heyday of the modular format.

The appeal of the slow

  • So we dived in.
  • Eventually, these forays became our formal research project, which has included visiting record fairs and conventions around the world, going on photowalks and attending listening evenings, and meeting an array of diehard analogue communities both on and off line.
  • The team is working with academics from different backgrounds who have been engaged in projects aimed at tackling societal and scientific challenges.
  • And we expect interest in such experiences to rise exponentially in coming years.
  • Recognising our existential need to occasionally slow down can be the basis for winning consumer strategies.
  • Recognising our existential need to occasionally slow down can be the basis for winning consumer strategies.

Saved from demolition

  • Rather than nostalgia, they are turning to film because of its aesthetic values and a greater sense of creative control over their photos.
  • In response, venerable brands including Kodak, Polaroid and Leica have re-emerged – in some cases, almost from the dead.
  • We literally saved it from demolition at the very last second in 2008.
  • We literally saved it from demolition at the very last second in 2008.
  • He said luxury brands such as Gucci are particularly keen on using film photography as this gives their promotional material a different look.

Work, effort, meaning

  • When it was conceded that digital probably was better for wildlife photography, James cut in:
    That’s to miss the point!
  • The sound might be better but you miss seeing the work that went into the performance, the effort of the players and their crew.
  • Work, effort, meaning – these ideas are all interconnected for users and consumers of analogue technology.
  • However, when asked to compare the two, they talk about the greater weight and meaning they give to their analogue experiences.
  • I think it is the quality of the human voice; it does feel more like someone’s speaking to me.
  • And part of what makes this possible is the process of analogue recording, in which all the sounds being made, including the unscripted noise of the recording process itself, are captured in the final track.
  • To facilitate this sound, some musicians have even started setting up their own pressing plants, such as Jack White’s Third Man Pressing in Detroit.

The joy of happy accidents

  • Half of what you do trying to make music is like a happy accident that ends up sounding better than what you intended.
  • When we started, we didn’t have that technology, so we made mistakes and some of them were happy accidents, resulting in iconic tracks.
  • When we started, we didn’t have that technology, so we made mistakes and some of them were happy accidents, resulting in iconic tracks.
  • It’s these happy accidents that we love.
  • It’s these happy accidents that we love.
  • For example, the opening bass part of Cannonball, the 1993 song by US Indie band the Breeders, accidentally starts in a different key.
  • Bass player Josephine Wiggs began playing the riff one step down, then fixed it when the drums came in.

Digital technology is de-skilling us

  • Over the decade or so of our research, explanations for the analogue revival have shifted from nostalgia, to the desire for something physical in a digital age, to the sense that analogue technology is creatively preferable.
  • Is digital technology de-skilling consumers, leading to a sense of alienation?
  • Using analogue technology is another way consumers can feed this desire to re-skill.
  • Rob told us how his love of music had turned sour with the “sheer ease” of digital, starting with CDs and the MP3 player – and how vinyl had reinvigorated him.
  • For him, the problem came when listening on digital devices without the “sides” of vinyl albums, and then on music streaming platforms whose digital algorithms preference popular tracks.

‘This song sucks’

  • These are the people who want to stretch and break the rules and trigger the happy accidents that create something altogether new.
  • For example, photographers who seek more creative expressions by pre-soaking or “souping” their camera film in lemon juice, coffee, beer, or even burning it.
  • And among this group, connecting digital and analogue technology is also common – combining two completely different systems to generate even more possibilities.
  • Film director Denis Villeneuve’s first instalment of Dune (2021) was initially shot on digital, then transferred to film, before being re-digitised.
  • By combining the two, Villeneuve got a film that, in his words, has a “more timeless, painterly feel”.


For you: more from our Insights series:
How music heals us, even when it’s sad – by a neuroscientist leading a new study of musical therapy

The artist formerly known as Camille – Prince’s lost album ‘comes out’

Beatrix Potter’s famous tales are rooted in stories told by enslaved Africans – but she was very quiet about their origins

To hear about new Insights articles, join the hundreds of thousands of people who value The Conversation’s evidence-based news. Subscribe to our newsletter.
The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

How to get vaccines to remote areas? In Sierra Leone they’re delivered by foot, boat or motorbike

Retrieved on: 
Thursday, April 18, 2024

In Sierra Leone almost 59% of the population live in remote, rural areas.

Key Points: 
  • In Sierra Leone almost 59% of the population live in remote, rural areas.
  • Roads may be non-existent or in bad condition, making it very difficult for rural dwellers to access healthcare.

Why are vaccination rates low in Sierra Leone?

  • In stark contrast, only 15% of people had been vaccinated in low-income countries.
  • The hardships Sierra Leoneans face are typical of the obstacles people in low-income countries have to overcome to access healthcare.
  • In the early days of the COVID-19 vaccination campaign in Sierra Leone, it took the average Sierra Leonean living in a rural community three-and-a-half hours each way to the nearest vaccination centre.

How did this vaccine drive tackle the problem?

  • The primary aim of this intervention was to take vaccine doses and nurses to administer vaccines to remote, rural communities, preceded by seeking permission and community mobilisation.
  • At the time, only 6% to 9% of the adults who took part in the programme were already immunised.
  • The leaders were asked for their cooperation in encouraging eligible community members to take the COVID-19 vaccine.
  • Finally, vaccine doses and healthcare workers arrived at the villages to administer the doses.

Looking forward

  • This approach proved 76% more cost-effective than other vaccination campaigns.
  • Transport accounted for a large share of the costs, so the cost-effectiveness of last mile delivery can be increased by offering a “bundle” of health products.
  • Other estimates put the death toll for the same period at 14.83 million, which is 2.74 times higher.
  • Developing cost-effective strategies to make vaccines easily accessible to everyone, everywhere, is the most promising solution to prevent future pandemics.


Niccolò Francesco Meriggi receives funding from Weiss Asset Management, UKRI and the International Growth Centre.

Draft revised Heads of Medicines Agency / European Medicines Agency guidance document on the identification of personal data and commercially confidential information within the structure of the marketing authorisation application dossier

Retrieved on: 
Thursday, April 18, 2024
Steps, Union, Patient, CTD, Syndrome, CCI, Local, Disclosure, Toxicity, Process validation, MAH, Clinical trial, IP, RMP, Pharmacovigilance, Cell, Legislation, Annex, Trial of the century, Escherichia coli, Safety, Pediatrics, INTRODUCTION, Documentation, Prevalence, Vital signs, Tablet, Design, Transparency, Conclusion, Pip, Analysis, European Parliament, INN, Record, Quality, Generic, Biology, CMO, Genotoxicity, Composition, CTIS, Uncontrolled, Health care, European Medicines Agency, Prejudice, Committee, Policy, HCP, Animal, Characterization, Cell bank, Fertility, IRB, CMOS, Risk management, Private law, European Pharmacopoeia, Telephone, Research, Good, Data Protection Directive, Ampere-hour, IEC, QP, Human, Personal data, Labelling, Bibliography, Figure, MAA, R4, Institutional review board, Elucidation, Marketing, M4, ChromeOS, Contract research organization, Mental, Impairment, Toxicokinetics, NCA, Independent, Metabolite, Drug, Risk, Metabolism, GMO, Organ, EMA, Common Technical Document, General Data Protection Regulation, Confidentiality, PPD, PI, Language, DRUG, Privacy, Result, Claimed, Medication, Comparison, Ethics, Drive, PD, Narrative, EEA, Developmental toxicity, Saccharomyces cerevisiae, Pharmacopoeia, PIP, MCB, HMA, Physical chemistry, Midol, Particle size, Council, GCP, European Economic Area, Draft, Fermentation, Overview, Justification, Control, Dicarboxylic acid, Pharmacology, WCB, Expert, Immunogenicity, Data, Study, Publication, European, ICH, Element, Analytical procedures (finance auditing), Name, Common, Guideline, Exceptional circumstances, ID, Liver, Chin Na, Toxicology, Protein primary structure, Immunosuppressive drug, Vaccine

See websites for contact details

Key Points: 
    • See websites for contact details
      Heads of Medicines Agencies www.hma.eu
      European Medicines Agency www.ema.europa.eu

      11

      Table of contents

      12

      Abbreviations .............................................................................................. 3

      13

      Definitions ................................................................................................... 4

      14

      1.

    • redaction, masking,

      68

      hiding) in such a manner that the recipient can no longer attribute the resulting information to a data

      69

      subject and make it identifiable.

    • 81

      Contract Manufacturing Organisation (CMO): shall mean an arrangement under which a

      82

      manufacturer provides upstream manufacturing services under contract on behalf of third-party

      83

      pharmaceutical companies.

    • 94

      Protected Personal Data (PPD): shall mean any personal data which should be protected from

      95

      disclosure.

    • ?Finalised? shall mean that the marketing

      102

      authorisation (MA) has been granted or refused or that the MAA has been withdrawn.

    • The application of the general principles laid down in this guidance is without prejudice to

      106

      national rules on transparency.

    • The guidance should be read in conjunction with the relevant applicable

      107

      legislation and case law on transparency and data protection.

    • 117

      This guidance document is intended to apply to information/documents on medicinal products for

      118

      human use, for which the procedure has been finalised under the national, mutual recognition,

      119

      decentralised and centralised procedures.

    • Third

      124

      parties shall be informed or consulted as needed depending on respective national and European legal

      125

      frameworks.

    • 140

      In the following sections, the agreed principles on PD and CCI are presented, including guidance on

      141

      whether such information can be disclosed.

    • EMA/131365/2024

      Page 5/50

      142

      Any information identified as PD or CCI must be subject to a preliminary review by the EMA/NCA prior

      143

      to the possible disclosure of the information/documents.

    • Principles on the protection of personal data (PD)

      145

      The protection of PD is enshrined in EU legislation; it is a fundamental right of EU citizens.

    • In

      146

      compliance with the applicable European/national legislation, PD should be anonymised in order to

      147

      avoid the disclosure of the document undermining the privacy and integrity of any individual.

    • EMA/NCA applies a risk-based approach to assess which PD elements are to be

      152

      removed from the information/documents in order to limit the risk of re-identification.

    • are included in the MAA dossier because they have a legally

      164

      defined role or responsibility and it is in the public interest to disclose this data.

    • 168

      Applicants are advised that non-essential information (e.g., personal address, personal phone number)

      169

      should not be included in the MAA dossier.

    • The

      183

      confidentiality of records that could identify subjects should be protected, respecting the privacy and

      184

      confidentiality rules in accordance with the applicable regulatory requirement(s).

    • 185

      The applicant remains responsible for compliance with the relevant legislation in cases where such data

      186

      is inadvertently included in the MAA dossier.

    • 188

      EMA/NCA applies a risk-based approach to assess which personal data elements need to be removed

      189

      from the information/documents in order to limit the risk of re-identification.

    • 194

      EMA/NCA applies a risk-based approach to assess which personal data elements need to be removed

      195

      from the information/documents in order to limit the risk of re-identification.

    • 205

      Any proposal to consider information as commercially confidential should be properly justified by the

      206

      owner of the information.

    • In this respect, any reference(s) to the risk of that interest being

      209

      undermined should be foreseeable and not purely hypothetical.

    • 210

      Information that is already in the public domain is not considered to be commercially confidential.

    • Information on the Quality and Manufacturing of medicines

      226

      A general principle regarding quality and manufacturing information is that detailed information could

      227

      be considered commercially confidential but general information should be disclosed.

    • 234

      In general, and if not in the public domain, the names of manufacturers or suppliers of the active

      235

      substance or the excipients are considered commercially confidential.

    • 248

      A general description of the type of test methods used and the appropriateness of the specification is

      249

      not commercially confidential.

    • General information on the fermentation and purification process

      259

      is not commercially confidential, although details including operating parameters and specific material

      260

      requirements are commercially confidential.

    • 273

      A general description of the type of test methods used and the appropriateness of the specification is

      274

      not commercially confidential.

    • In general, the data included in clinical trial study reports is considered to be data that can be

      283

      disclosed once PD has been anonymised.

    • 338

      In each module, a non-exhaustive list of information that may be considered protected personal data (PPD) or commercially confidential information

      332
      333

      339

      (CCI) is included.

    • ?

      Direct contact details such as telephone

      Therefore, please refer to the appropriate sub-

      number, fax number, email, postal address,

      modules hereafter for guidance.

    • ?

      Information that may reveal strategic
      (contractual) agreements

      ?

      Any quality information on the clinical batches

      principal investigator

      that might be included here (such as e.g.

    • ?

      Information that may reveal strategic
      (contractual) agreements

      principal investigator

      Study Reports
      5.3.3.3

      as the evaluation of new formulation, innovative

      number, fax number, email, postal

      Paediatric Development Plan (PIP), etc.

    • This may include taking into

      More Than One Study
      5.3.5.4

      Other Clinical Study Reports

      5.3.6

      Reports of Post-Marketing
      Experience

      5.3.7

      Direct identifiers such as name,
      signature, contact details, etc.

EQS-News: Beyond SoftPOS by RS2: The New Acceptance Solution for Merchants - Now Available on Google Play Store

Retrieved on: 
Wednesday, April 10, 2024

FRANKFURT, 20 March 2024 – Beyond by RS2, a division of the RS2 Group renowned for its global leadership in payment processing and technology, has launched the Beyond SoftPOS payment app on the Google Play Store.

Key Points: 
  • FRANKFURT, 20 March 2024 – Beyond by RS2, a division of the RS2 Group renowned for its global leadership in payment processing and technology, has launched the Beyond SoftPOS payment app on the Google Play Store.
  • Beyond SoftPOS enables businesses to convert any Android device into a payment acceptance solution to accept payments anywhere at any time.
  • Beyond SoftPOS is now available on Google Play Store and can be downloaded by merchants directly onto their Android smartphones, tablets and multi-purpose- devices.
  • Beyond SoftPOS is an innovative approach to payment acceptance, delivering benefits for consumers, merchants and partners alike.

Nagakawa and u-blox join forces to optimize energy consumption and reduce CO2 emissions in Vietnam buildings

Retrieved on: 
Wednesday, April 10, 2024

The aim is to optimize energy consumption and reduce CO2 emissions in various buildings in Vietnam.

Key Points: 
  • The aim is to optimize energy consumption and reduce CO2 emissions in various buildings in Vietnam.
  • Such innovative developments will contribute to the Vietnamese government achieving its goal of net-zero CO2 emissions by 2050.
  • Supported by BEMServer, described as the world’s premier open source building energy management platform, and enabling manual or automatic adjustment of HVAC/VRF systems, the solution will help curb energy consumption and reduce CO2 emissions.
  • Nagakawa is partnering with u-blox and the BEESOTA 6G Alliance to build a comprehensive system, with gradual implementation into buildings planned throughout Vietnam.

Greater Good Charities and Boehringer Ingelheim Kick Off Fourth Year of Good Flights Program and Celebrate Successful Transport of More Than 12,800 Shelter Pets to Adoptive Homes Including Nearly 1,300 Asymptomatic Heartworm-Positive Dogs

Retrieved on: 
Monday, April 8, 2024

To kick off the fourth year of Good Flights, a special transport of more than 45 shelter pets will take place on April 8 from Louisiana to the East Coast.

Key Points: 
  • To kick off the fourth year of Good Flights, a special transport of more than 45 shelter pets will take place on April 8 from Louisiana to the East Coast.
  • Air and ground transports for Good Flights occur approximately five times a month and many have Save a Heart pets on them.
  • “The Good Flights Program and Save a Heart initiative represents a remarkable collaboration between Greater Good Charities and Boehringer Ingelheim,” said Dr. Julie Ryan-Johnson, Senior Associate Director - Shelter Engagement Program, Boehringer Ingelheim.
  • Good Flights covers transport costs, provides mentorship, pharmaceuticals, and furnishes much needed supplies including pet crates, bowls, and leashes.

Entera Bio Announces Publication of Oral PTH(1-34) Peptide Tablets (EB613) Phase 2 Trial Data in the Journal of Bone and Mineral Research

Retrieved on: 
Monday, April 8, 2024

Miranda Toledano, CEO of Entera, commented, “We are excited to share that data from our successful Phase 2 study of EB613 has been accepted and now published in the prestigious JBMR.

Key Points: 
  • Miranda Toledano, CEO of Entera, commented, “We are excited to share that data from our successful Phase 2 study of EB613 has been accepted and now published in the prestigious JBMR.
  • We believe EB613 addresses the current treatment gap in osteoporosis as the first oral, osteoanabolic (bone building) once-daily tablet treatment due to its unique format and potential dual mode of action.
  • The highest EB613 oral PTH tablet dose (2.5 mg), produced an increase in markers of bone formation while simultaneously decreasing the markers of bone breakdown.
  • The 2.5 mg oral PTH tablet dose was well tolerated when patients were instructed to titrate up to the full dose.

Esperion Presents Important New Data from CLEAR Outcomes at ACC.24 Highlighting Value of NEXLETOL® (bempedoic acid) Tablets in Diverse Populations Including Women, Hispanics/Latinx and Patients with Obesity

Retrieved on: 
Sunday, April 7, 2024

ANN ARBOR, Mich., April 07, 2024 (GLOBE NEWSWIRE) -- Esperion (Nasdaq: ESPR) today announced the presentation of results from three pre-specified subgroups from CLEAR Outcomes at the 2024 American College of Cardiology’s Annual Scientific Sessions (ACC.24): women, Hispanic/Latinx, and patients with obesity. These results align with the American College of Cardiology’s robust diversity, equity and inclusion programs to drive cultural change across the profession and ensure that the cardiovascular care team is as diverse as the patients they care for and that all patients are represented in cardiovascular research. The data also reinforce the mission of the ACC: transforming cardiovascular care for all.

Key Points: 
  • “Bempedoic acid is the only FDA approved non-statin LDL lowering therapy to demonstrate reductions in MACE in both primary prevention and secondary prevention patient populations.
  • The Hispanic population is the largest ethnic minority in the U.S., yet is a population historically underrepresented in clinical trials.
  • At Esperion, we discover, develop, and commercialize innovative medicines to help improve outcomes for patients with or at risk for cardiovascular and cardiometabolic diseases.
  • CLEAR Outcomes is part of the CLEAR clinical research program for NEXLETOL® (bempedoic acid) Tablet and NEXLIZET® (bempedoic acid and ezetimibe) Tablet.

DigiCert and Macnica Bring Matter-Enabled Smart Home Solutions to Panasonic Room Air Products

Retrieved on: 
Tuesday, April 2, 2024

Selected by CSA as the world's first Matter Root CA, DigiCert supports the project with high security and support capabilities backed by professional experience and knowledge based on the company’s certificate business experience and wide adoption worldwide. Macnica, with its expertise in the IoT and IT domains, played an important role in the implementation of the Matter-compliant digital certificates at Panasonic Group’s production plant--from deal discovery and management through implementation and post-deployment technical support. 

Key Points: 
  • Together, they will introduce the first room air conditioner in India equipped with Matter 1.21, a common standard for smart homes.
  • The certificates allow Panasonic room air conditioners to be seamlessly integrated into the Matter ecosystem, enabling users to control and monitor their room air conditioners from Matter-enabled devices such as smart speakers, smartphones, and tablets.
  • The Panasonic room air conditioner series equipped with the Matter Protocol is available at all major retailers and e-commerce platforms in India.
  • “The security of Panasonic room air conditioners has been greatly enhanced by adopting the latest solutions from DigiCert, a leading provider of digital certificates, in addition to the security-oriented Matter standard.

Junshi Biosciences Announces 2023 Full Year Financial Results and Provides Corporate Updates

Retrieved on: 
Friday, March 29, 2024

SHANGHAI, China, March 29, 2024 (GLOBE NEWSWIRE) -- Shanghai Junshi Biosciences Co., Ltd (“Junshi Biosciences,” HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, announced its financial results for the full year of 2023 and provided corporate updates.

Key Points: 
  • SHANGHAI, China, March 29, 2024 (GLOBE NEWSWIRE) -- Shanghai Junshi Biosciences Co., Ltd (“Junshi Biosciences,” HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, announced its financial results for the full year of 2023 and provided corporate updates.
  • Total research and development (“R&D”) expenses were approximately RMB1,937 million in 2023, representing a decrease of approximately 19% compared to 2022.
  • Loss attributable to owners was RMB2,282 million in 2023, representing a decrease of RMB104 million compared to the previous year.
  • This application was later approved for marketing in December 2023, marking the first and only approved perioperative therapy for lung cancer domestically.