Intravacc and DZNE awarded EU funding to develop vaccine against genetic ALS variant
The project aims to develop the vaccine candidate identified at DZNE to the point where it can be clinically tested in humans.
- The project aims to develop the vaccine candidate identified at DZNE to the point where it can be clinically tested in humans.
- About 5-10% of all ALS cases are caused by a mutation in the C9orf72 gene, making it the most common genetic ALS variant.
- DZNE developed an experimental vaccine that instructs the immune system to produce antibodies against these harmful poly-GA molecules.
- Clinical trials for C9orf72 ALS, which is the most common genetic variant of ALS, are expected to commence in 2025.