Population

Multi-stakeholder workshop on the guideline on clinical investigation of medicinal products in the treatment of epileptic disorders , Online, 29 January 2024

Retrieved on: 
Monday, December 18, 2023

Date

Key Points: 
  • Date
    - Monday, 29 January 2024
    Location
    - Online
    Event summary
    EMA is organising an online multi-stakeholder workshop on the revised guideline on clinical investigation of medicinal products in the treatment of epileptic disorders.
  • The guideline has been revised to bring together the current knowledge in seizures type and epilepsy.
  • The revised guideline (revision 3) is under public consultation.
  • The intention of the revised guideline is to provide general guidance on the development of medicinal products for the treatment of epileptic disorders, to support evidence generation, to enable appropriate methodology for the evaluation of medicinal product for the treatment of epileptic disorders and to further inform regulatory decision making.

'News overload': how a constant stream of violent images affects your brain

Retrieved on: 
Thursday, November 9, 2023

Even then, they would only have heard accounts of the events, without images or videos to reproduce exactly what happened.

Key Points: 
  • Even then, they would only have heard accounts of the events, without images or videos to reproduce exactly what happened.
  • In today’s world, omnipresent communication technology means the spread of horrific images is all but impossible to escape.
  • We experience this now, for example, with images from Israel and Gaza, and other wars and attacks in recent years.

Images that release cortisol

  • Even when viewed through a phone screen, experiencing an extremely violent situation activates the sympathetic branch of our nervous systems, which governs our “fight or flight” response.
  • Our bodies react to these images by secreting hormones into the bloodstream including adrenaline, noradrenaline and cortisol, commonly known as the stress hormone.
  • If they become chronic, they can cause serious health problems in the long run, as has been common knowledge for decades.

Poor memory and a loss of control

  • In acutely stressful situations the hippocampus’ role in memory becomes inhibited, and the prefrontal cortex ceases to exercise control.
  • These changes are, in principle, intended to help us cope with specific stressful situations in the short term.
  • When we face a threat the priority is to react quickly, not taking time to remember similar events and analyse contextual factors.
  • This is essentially because chronic stress causes problems for our learning and memory, affecting three areas which are worth exploring in more detail: precision, flexibility and reconsolidation.


Francisco Javier Saavedra Macías no recibe salario, ni ejerce labores de consultoría, ni posee acciones, ni recibe financiación de ninguna compañía u organización que pueda obtener beneficio de este artículo, y ha declarado carecer de vínculos relevantes más allá del cargo académico citado.

Skulls in Ukraine reveal early modern humans came from the East

Retrieved on: 
Thursday, November 9, 2023

Published in Nature Ecology & Evolution, our new study analyses two skull fragments dating back between 37,000 and 36,000 years to conclude that our ancestors came from Eastern Europe and migrated westwards.

Key Points: 
  • Published in Nature Ecology & Evolution, our new study analyses two skull fragments dating back between 37,000 and 36,000 years to conclude that our ancestors came from Eastern Europe and migrated westwards.
  • These individuals are the oldest representatives of Western Europeans to have established themselves permanently in Europe and to have left traces in the genomes of present-day Europeans.
  • It is estimated they settled in the region after the ice age that took place from 40,000 to 38,000 years ago.
  • Up to this day, researchers believe that the ensuing ecological crisis wiped out both the last Neanderthal populations and the first populations of sapiens humans of the early Upper Palaeolithic.

Homo sapiens from interbreeding

  • Both individuals are descendants of distant interbreeding with Neanderthals.
  • Our study also showed that the more recent individual bore traces of interbreeding with individuals from the first wave of settlement thought to have been exterminated by the -40,000 year ice age, represented by the Zlatý Kůň individual (-45,000 years).
  • We were therefore able to conclude that the first H. sapiens were not completely replaced and some must have survived the ecological crisis.

Links with fossils found in France

  • These individuals, close to those from Buran Kaya III, were part of the population associated with the Classical Gravettian period, which produced the female ivory statuettes known as the “Gravettian Venuses” found in France, Germany, Austria and the Czech Republic.
  • The famous Venus “Dame de Brassempouy” from the French department of Landes was sculpted at this time.
  • The genetic ties indicate that these populations spread from east to west.
  • The “Génétique et epigénétique nouvelle ecole” project is supported by the French National Research Agency (ANR), which funds project-based research in France.
  • Its mission is to support and promote the development of fundamental and applied research in all disciplines, and to strengthen the dialogue between science and society.


Eva-Maria Geigl has received funding from CNRS, EUR G.E.N.E. (ANR-17-EURE-0013 ; IdEx #ANR-18-IDEX-0001 l'Université de Paris ; Programme d'Investissements d'Avenir) Thierry Grange has received funding from the Fondation pour la Recherche Médicale (DGE20111123014), Région Ile-de-France (11015901), CNRS, EUR G.E.N.E. (ANR-17-EURE-0013 ; IdEx #ANR-18-IDEX-0001 l'Université de Paris ; Programme d'Investissements d'Avenir).

Cranberries can bounce, float and pollinate themselves: The saucy science of a Thanksgiving classic

Retrieved on: 
Thursday, November 9, 2023

Cranberries are a staple in U.S. households at Thanksgiving – but how did this bog dweller end up on holiday tables?

Key Points: 
  • Cranberries are a staple in U.S. households at Thanksgiving – but how did this bog dweller end up on holiday tables?
  • But as a plant scientist, I’ve learned much about cranberries’ ancestry from their botany and genomics.

New on the plant breeding scene

  • Humans have cultivated sorghum for some 5,500 years, corn for around 8,700 years and cotton for about 5,000 years.
  • In contrast, cranberries were domesticated around 200 years ago – but people were eating the berries before that.
  • Today, Wisconsin produces roughly 60% of the U.S. cranberry harvest, followed by Massachusetts, Oregon and New Jersey.

A flexible and adaptable plant

  • Like roses, lilies and daffodils, cranberry flowers are hermaphroditic, which means they contain both male and female parts.
  • The flower’s resemblance to the beak of a bird earned the cranberry its original name, the “craneberry.”
  • They can also be propagated sexually, by planting seeds, or asexually, through rooting vine cuttings.
  • This is important for growers because seed-based propagation allows for higher genetic diversity, which can translate to things like increased disease resistance or more pest tolerance.
  • These pockets serve a biological role: They enable the berries to float down rivers and streams to disperse their seeds.

Reading cranberry DNA

  • The cranberry is a diploid, which means that each cell contains one set of chromosomes from the maternal parent and one set from the paternal parent.
  • It has 24 chromosomes, and its genome size is less than one-tenth that of the human genome.
  • Insights like these help scientists better understand where potentially valuable genes might be located in the cranberry genome.
  • Researchers are developing molecular markers – tools to determine where certain genes or sequences of interest reside within a genome – to help determine the best combinations of genes from different varieties of cranberry that can enhance desired traits.

Ripe at the right time

  • Fresh cranberries are ready to harvest from mid-September through mid-November, so Thanksgiving falls within that perfect window for eating them.
  • In recent decades, the cranberry industry has branched out into juices, snacks and other products in pursuit of year-round markets.


Serina DeSalvio does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Chechnya's boss and Putin’s foot soldier: How Ramzan Kadyrov became such a feared figure in Russia

Retrieved on: 
Thursday, November 9, 2023

The orders came in the wake of an antisemitic riot that broke out on Oct. 29, 2023, in the neighboring Russian republic of Dagestan.

Key Points: 
  • The orders came in the wake of an antisemitic riot that broke out on Oct. 29, 2023, in the neighboring Russian republic of Dagestan.
  • It is not that Kadyrov doesn’t support the Palestinian cause; he does.
  • Kadyrov is both feared and venerated throughout Russia, and even more so since the beginning of the full-scale invasion of Ukraine in 2022.
  • How did the leader of a small North Caucasian republic become such a feared figure in Russia?

Ruthless rise to power

  • Shortly after the beginning of the second Chechen war, which lasted from 1999 to 2009, Putin – who increased his power and popularity due to his aggressive role in the conflict – installed Akhmat as the leader of the republic.
  • He used these years to consolidate his power and ensure his political ascension.
  • To achieve this, he worked on eliminating his political rivals, including those who were once close to his father.

Violent suppression of dissent

  • This highly professional paramilitary force, colloquially known as the “Kadyrovtsy,” is formally integrated into the interior ministry and national guard.
  • These troops serve as a private army that suppresses dissent within the republic and eliminates Kadyrov’s opponents beyond its borders.
  • Kadyrovtsy also fought in the Syrian civil war as part of Russia’s military support for Syrian president Bashar Assad.

Zealous loyalty to Putin

  • This autonomy is largely due to the personal relationship between Putin and Kadyrov.
  • Soon after Akhmat Kadyrov’s death, Ramzan famously arrived at the Kremlin wearing a tracksuit, and Putin sincerely comforted the grief-stricken young man.
  • In return for Kadyrov’s zealous loyalty and his largely successful efforts in suppressing the North Caucasian insurgency, Putin ceded nearly complete control of Chechnya.

Islam as a political tool

  • Under Kadyrov, Sufism in Chechnya flourished and became the only acceptable form of Islam.
  • Within Chechnya, Kadyrov uses religion to galvanize supporters and demonstrate his political power.
  • Kadyrov, meanwhile, also uses Islam to boost his profile on the international stage and bolster his political standing in Russia.

‘I am the boss!’

  • He presides over Chechnya – which waged two wars against Russia in the past 30 years in pursuit of independence – with impunity.
  • I am at the steering wheel!” Kadyrov boldly proclaimed in 2011, a mere four years after Putin installed him as the republic’s president.
  • Russian law seems powerless to hold Kadyrov accountable, a fact the Chechen strongman underscored in 2015.
  • While he remains loyal to Putin, he has his own agenda and cannot afford to be seen as weak.


The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

Sleep apnoea can be scary. But here's what happened when First Nations people had a say in their own care

Retrieved on: 
Wednesday, November 8, 2023

But the truth is, this sleep-related respiratory disorder is significantly under-reported in First Nations communities.

Key Points: 
  • But the truth is, this sleep-related respiratory disorder is significantly under-reported in First Nations communities.
  • Read more:
    The first sleep health program for First Nations adolescents could change lives

What is obstructive sleep apnoea?

  • In obstructive sleep apnoea the upper airway is repeatedly wholly or partially blocked during sleep, resulting in lower blood oxygen levels.
  • Sleep apnoea also increases the risk of obesity, heart disease, cognitive problems, poor mental health, productivity loss and driving accidents.
  • Another reason why we suspect sleep apnoea is under-reported is the
    lack of specialist sleep services in rural and remote areas.

A growing awareness

  • This builds on insights from community yarns about the impact of poor sleep.
  • These highlighted that dreaming in First Nations culture is considered an important opportunity to connect with ancestors, Country and cultural knowledge.
  • So, poor sleep, through its impact on dreaming, also affects spiritual health.
  • The program’s yarn with community members also highlighted the lack of culturally secure services, low awareness of sleep apnoea treatment options and stigma in accessing services as the key contributors to high rates of undiagnosed/untreated sleep apnoea in First Nations communities.
  • There is still shame in talking about sleep apnoea.
  • I was tested for sleep apnoea, and the doctor told me I stopped breathing 13 times [per hour] in my sleep.
  • I was tested for sleep apnoea, and the doctor told me I stopped breathing 13 times [per hour] in my sleep.

So what does the program look like?

  • This has involved consultation with 12 First Nations communities, and training Aboriginal health workers and nurses to deliver the program.
  • The Aboriginal health workers will educate community members about symptoms of sleep apnoea, its health impacts and pathways to seek clinical care.
  • The program uses standard treatments for sleep apnoea, such as continuous positive airway pressure therapy, known as a CPAP machine.


Read more:
Friday essay: the remarkable yidaki (and no, it's not a 'didge')

Locally-led, culturally responsive

  • It’s early days for us to see any results from the program.
  • But it shows we can develop locally led and culturally responsive models of care.
  • Yaqoot Fatima is supported by funding from the NHMRC Partnership Grant, MRFF Indigenous Health Research Grant, MRFF-EMCR grant, Tropical Australian Academic Health Centre grant and Beyond Blue for sleep health research.
  • Daniel Sullivan is a member of the Australasian Sleep Association and the Australian Psychological Society.
  • Daniel Sullivan receives funding from a Medical Research Future Fund Early-Mid Career Researchers grant.

Ketamine can rapidly reduce symptoms of PTSD and depression, new study finds

Retrieved on: 
Wednesday, November 8, 2023

The drug ketamine can reduce the symptoms of post-traumatic stress disorder, or PTSD, and symptoms of depression in patients as early as a day after injection.

Key Points: 
  • The drug ketamine can reduce the symptoms of post-traumatic stress disorder, or PTSD, and symptoms of depression in patients as early as a day after injection.
  • Patients receiving ketamine saw their PTSD symptoms reduced by about 25% both at one day and one week after therapy.
  • Ketamine might be an effective bridge to immediately reduce patients’ symptoms until trauma-focused psychotherapy and other antidepressants can kick in.
  • What still isn’t known
    The big unknown with using ketamine for PTSD and depressive symptoms is how often the injections are needed.

Russia's decision to ditch cold war arms limitation treaty raises tensions with Nato

Retrieved on: 
Wednesday, November 8, 2023

It added that the admission of Finland into Nato and Sweden’s application meant the treaty was dead.

Key Points: 
  • It added that the admission of Finland into Nato and Sweden’s application meant the treaty was dead.
  • The CFE treaty had aimed to reduce the opportunity for either side to launch a rapid offensive against the other.
  • In fact, the US never ratified the treaty and Moscow and Washington have exchanged angry words, each accusing the other of undermining the NTBT.
  • This has helped nobody – activity in both the US and Russia has escalated tensions over nuclear testing.

Aggressive stance

  • Moscow’s increasingly aggressive stance will certainly add to concerns for the Baltic states and Poland.
  • With a significant number of ethnic Russians as part of their populations, the risks of civil unrest leading to an escalation is rather high.
  • But the Russians would need to be more competent and capable in their military adventures than they have been shown to be in Ukraine.
  • The likelihood of a Russian attack is small, but Putin likes to keep his options open.
  • He is also an experienced propagandist and will use whatever levers he has to try and prise Nato’s members apart.


Kenton White does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Do you think you have a penicillin allergy? You might be wrong

Retrieved on: 
Wednesday, November 8, 2023

Originally derived from a fungus, penicillin antibiotics such as amoxicillin are used to treat common infections, including chest, sinus, ear, urinary tract and skin infections.

Key Points: 
  • Originally derived from a fungus, penicillin antibiotics such as amoxicillin are used to treat common infections, including chest, sinus, ear, urinary tract and skin infections.
  • Up to 20% of Australians admitted in hospital say they have a penicillin allergy.
  • Read more:
    Weekly Dose: penicillin, the mould that saves millions of lives

Why does it matter?

  • People who mistakenly think they’re allergic to penicillin may not get the most effective or safest antibiotics to treat their infection.
  • They are also at greater risk of developing multidrug-resistant infections or “superbugs”.
  • People who receive second-line antibiotics are more likely to have complications, such as antibiotic-induced gut infections.

Why do people think they’re allergic?

  • They may have experienced side effects from penicillin, such as nausea or diarrhoea.
  • An Epstein-Barr viral infection treated with amoxicillin, for example, causes a fine, red rash.
  • But there is no evidence penicillin allergy is inherited.
  • Then there are people who have had a genuine and serious reaction to penicillin.

Testing for penicillin


When someone says they have a penicillin allergy, we first get them to explain what happened with the reaction, including to what antibiotic, in what context and how severe it was. Then we perform skin tests to further assess the person’s risk of reaction. If skin tests are negative, we can then give the patient the penicillin in question under supervision (a “challenge”) to see if they react.

  • Our study followed 195 patients who reported a penicillin allergy across six Sydney hospitals.
  • In the first phase, we assessed 85 people and found 82% weren’t allergic to penicillin.
  • In our study, eight weeks after their test, just 54% of participants in phase one correctly knew their penicillin allergy status.

Reducing long waits for allergy tests

  • The wait time from someone first being referred to an allergy clinic to having testing can be up to two years.
  • We need to improve access to testing and also look at when people can access allergy services.
  • We also need to ensure the results of allergy tests translate to the real world so people know their true allergy status.
  • Winnie Tong has received funding from Maridulu Budyari Gumal, the Sydney Partnership for Health, Education, Research and Enterprise (SPHERE), Triple I Clinical Academic Group seed grant 2017, and the Balnaves Foundation.
  • The authors would like to acknowledge Professor Andrew Carr, their collaborators and participants on this project.