Genetics

Chemical pollutants can change your skin bacteria and increase your eczema risk − new research explores how

Retrieved on: 
Tuesday, April 23, 2024

Also known as atopic dermatitis, this chronic skin disease affects about 1 in 5 children in the industrialized world.

Key Points: 
  • Also known as atopic dermatitis, this chronic skin disease affects about 1 in 5 children in the industrialized world.
  • Some studies have found rates of eczema in developing nations to be over thirtyfold lower compared with industrialized nations.
  • Scientists know that factors such as diets rich in processed foods as well as exposure to specific detergents and chemicals increase the risk of developing eczema.
  • Living near factories, major roadways or wildfires increase the risk of developing eczema.

There’s something in the air

  • Then we looked at databases from the U.S. Environmental Protection Agency to see which chemicals were most common in those areas.
  • Diisocyanates were first manufactured in the U.S. around 1970 for the production of spandex, nonlatex foam, paint and polyurethane.
  • The manufacture of xylene also increased around that time, alongside an increase in the production of polyester and other materials.
  • After 1975, when all new cars became outfitted with a new technology that converted exhaust gas to less toxic chemicals, isocyanate and xylene both became components of automobile exhaust.
  • How directly exposing mice to these toxins compares to the typical levels of exposure in people is still unclear.

Skin microbiome and pollution

  • Every person is coated with millions of microorganisms that live on the skin, collectively referred to as the skin microbiome.
  • You’ve probably seen moisturizers and other skin products containing ceramides, a group of lipids that play an important role in protecting the skin.
  • To see which toxins could prevent production of the beneficial lipids that prevent eczema, my team and I used skin bacteria as canaries in the coal mine.
  • Lysine helps protect the bacteria from the harms of the toxins but doesn’t provide the health benefits of ceramides.
  • Bacteria that help keep skin healthy could live on any fabric, but, just as with air pollution, the amount of beneficial lipids they made dropped to less than half the levels made when grown on fabrics like cotton.

Addressing pollution’s effects on skin

  • Detectors capable of sensing low levels of isocyanate or xylene could help track pollutants and predict eczema flare-ups across a community.
  • Better detectors can also help researchers identify air filtration systems that can scrub these chemicals from the environment.
  • In the meantime, improving your microbial balance may require avoiding products that limit the growth of healthy skin bacteria.
  • I believe that it may one day allow us to get back to a time when these diseases were uncommon.


Ian Myles receives funding from the Department of Intramural Research at the National Institute of Allergy and Infectious Diseases. He is the author of, and receives royalties for, the book GATTACA Has Fallen: How population genetics failed the populace. Although he is the co-discoverer of Roseomonas mucosa RSM2015 for eczema, he has donated the patent to the public and has no current conflict of interest for its sales.

Good news: midlife health is about more than a waist measurement. Here’s why

Retrieved on: 
Friday, April 19, 2024

During the appointment they measure your waist.

Key Points: 
  • During the appointment they measure your waist.
  • GPs and health professionals commonly measure waist circumference as a vital sign for health.
  • Men are at greatly increased risk of health issues if their waist circumference is greater than 102 centimetres.
  • More than two-thirds of Australian adults have waist measurements that put them at an increased risk of disease.

How much is too much?

  • A ratio of 0.6 or more places a person at the highest risk of disease.
  • This can kick off a discussion about their risk of chronic diseases and how they might address this.
  • For women, hormone levels begin changing in mid-life and this also stimulates increased fat levels particularly around the abdomen.
  • Finally, your family history and genetics can make you predisposed to gaining more abdominal fat.

Why the waist?

  • Visceral fat surrounds and infiltrates major organs such as the liver, pancreas and intestines, releasing a variety of chemicals (hormones, inflammatory signals, and fatty acids).
  • These affect inflammation, lipid metabolism, cholesterol levels and insulin resistance, contributing to the development of chronic illnesses.
  • In addition to the direct effects of hormone changes, declining levels of oestrogen change brain function, mood and motivation.
  • These psychological alterations can result in reduced physical activity and increased eating – often of comfort foods high in sugar and fat.
  • And importantly, the waist circumference (and ratio to height) is just one measure of human health.

Muscle matters

  • On current evidence, it is equally or more important for health and longevity to have higher muscle mass and better cardiorespiratory (aerobic) fitness than waist circumference within the healthy range.
  • So, if a person does have an excessive waist circumference, but they are also sedentary and have less muscle mass and aerobic fitness, then the recommendation would be to focus on an appropriate exercise program.
  • Conversely, a person with low visceral fat levels is not necessarily fit and healthy and may have quite poor aerobic fitness, muscle mass, and strength.

Getting moving is important advice

  • Exercise can counter a lot of the negative behavioural and physiological changes that are occurring during midlife including for people going through menopause.
  • And regular exercise reduces the tendency to use food and drink to help manage what can be a quite difficult time in life.
  • Measuring your waist circumference and monitoring your weight remains important.


Rob Newton receives funding from National Health and Medical Research Council, the Medical Research Future Fund, Cancer Council Western Australia, Spinal Cord Injuries Australia and the World Cancer Research Fund. Rob Newton is a board member of The Healthy Male.

Billions of cicadas are about to emerge from underground in a rare double-brood convergence

Retrieved on: 
Thursday, April 18, 2024

From late April through June 2024, the largest brood of 13-year cicadas, known as Brood XIX, will co-emerge with a midwestern brood of 17-year cicadas, Brood XIII.

Key Points: 
  • From late April through June 2024, the largest brood of 13-year cicadas, known as Brood XIX, will co-emerge with a midwestern brood of 17-year cicadas, Brood XIII.
  • A co-emergence like this of two specific broods with different life cycles happens only once every 221 years.
  • For about four weeks, scattered wooded and suburban areas will ring with cicadas’ distinctive whistling, buzzing and chirping mating calls.
  • Once the eggs hatch, new cicada nymphs will fall from the trees and burrow back underground, starting the cycle again.
  • It’s no accident that the scientific name for periodical 13- and 17-year cicadas is Magicicada, shortened from “magic cicada.”

Ancient visitors

  • Molecular analysis has shown that about 4 million years ago, the ancestor of the current Magicicada species split into two lineages.
  • The resulting three lineages are the basis of the modern periodical cicada species groups, Decim, Cassini and Decula.
  • The sudden appearance of so many insects reminded them of biblical plagues of locusts, which are a type of grasshopper.
  • During the 19th century, notable entomologists such as Benjamin Walsh, C.V. Riley and Charles Marlatt worked out the astonishing biology of periodical cicadas.

Acting in unison

  • This increases their chances of accomplishing their key mission aboveground: finding mates.
  • While periodical cicadas largely come out on schedule every 17 or 13 years, often a small group emerges four years early or late.
  • Early-emerging cicadas may be faster-growing individuals that had access to abundant food, and the laggards may be individuals that subsisted with less.

Will climate change shift Magicicada clocks?

  • As glaciers retreated from what is now the U.S. some 10,000 to 20,000 years ago, periodical cicadas filled eastern forests.
  • Today there are 12 broods of 17-year periodical cicadas in northeastern deciduous forests, where trees drop leaves in winter.
  • Because periodical cicadas are sensitive to climate, the patterns of their broods and species reflect climatic shifts.
  • Although periodical cicadas prefer forest edges and thrive in suburban areas, they cannot survive deforestation or reproduce successfully in areas without trees.
  • In the late 19th century, one Brood (XXI) disappeared from north Florida and Georgia.
  • Climate change could also have farther-reaching effects.
  • As the U.S. climate warms, longer growing seasons may provide a larger food supply.
  • This may eventually change more 17-year cicadas into 13-year cicadas, just as past warming altered Magicicada neotredecim.
  • We hypothesize that this was due to climate warming.


John Cooley receives funding from the National Science Foundation and the National Geographic Society. Chris Simon has received funding from the National Science Foundation, the Fulbright Foundation, the National Geographic Society and the New Zealand Marsden Fund.

Global AI Show and Global Blockchain Show Premier in Dubai

Retrieved on: 
Thursday, March 28, 2024

Furthermore, the Global AI Show and the Global Blockchain Show are thrilled to have the world's first AI humanoid robot Sophia as their Official Ambassador.

Key Points: 
  • Furthermore, the Global AI Show and the Global Blockchain Show are thrilled to have the world's first AI humanoid robot Sophia as their Official Ambassador.
  • Meanwhile, a community stage at the Global Blockchain Show and the Global AI Show will be set up to focus on fostering inclusivity, collaboration, and engagement within the blockchain and AI community.
  • The Global AI Awards and the Global Blockchain Awards seek to recognise excellence and innovation, and pay tribute to the trailblazers, innovators and guardians who tirelessly push the boundaries of possibility in the field of AI and blockchain technology.
  • The Global AI Show and the Global Blockchain Show will finish with an afterparty at the luxurious White Beach at Atlantis, The Palm.

Jamie Metzl to Speak on AI, Genetics, and Biotechnology Revolutions at the Global AI Show

Retrieved on: 
Friday, March 22, 2024

Jamie Metzl, one of the world's leading technology and healthcare futurists, is all set to headline at the Global AI Show, taking place at the Grand Hyatt Dubai on April 16 and 17, 2024.

Key Points: 
  • At the Global AI Show, Metzl will be exploring the power of genetic technologies and AI, and their potential to reshape human life.
  • He will discuss the scientific breakthroughs and real-world applications of genetic technologies, thereby bringing unmissable insights into AI and biological revolutions.
  • "I am thrilled to be Headlining at the Global AI Show, the world's premier event for artificial intelligence.
  • Metzl's inclusion as a speaker underscores the caliber of expertise and insight that attendees can expect at the Global AI Show.

How AI, Genetics and Biotechnology Revolutions will Transform our Future: Jamie Metzl at the Global AI Show

Retrieved on: 
Sunday, March 24, 2024

DUBAI, Mar 25, 2024 - (ACN Newswire) - The Global AI Show is thrilled to announce Jamie Metzl, esteemed author, technology visionary, and healthcare futurist, as a featured speaker for its upcoming two-day conference.

Key Points: 
  • DUBAI, Mar 25, 2024 - (ACN Newswire) - The Global AI Show is thrilled to announce Jamie Metzl, esteemed author, technology visionary, and healthcare futurist, as a featured speaker for its upcoming two-day conference.
  • At the Global AI Show, Metzl will be exploring the power of genetic technologies and AI, and their potential to reshape human life.
  • He will discuss the scientific breakthroughs and real-world applications of genetic technologies, thereby bringing unmissable insights into AI and biological revolutions.
  • "I am thrilled to be Headlining at the Global AI Show, the world's premier event for artificial intelligence.

Myriad Genetics Research Shows Reduction in Hospitalizations for Patients with Depression after GeneSight Testing

Retrieved on: 
Tuesday, April 9, 2024

(NASDAQ: MYGN), a leader in genetic testing and precision medicine, revealed results from a multi-year, real-world study of nearly 21,000 patients that indicated those with major depressive disorder had reduced healthcare utilization after taking the GeneSight® Psychotropic test .

Key Points: 
  • (NASDAQ: MYGN), a leader in genetic testing and precision medicine, revealed results from a multi-year, real-world study of nearly 21,000 patients that indicated those with major depressive disorder had reduced healthcare utilization after taking the GeneSight® Psychotropic test .
  • “We are encouraged by the initial results of this study that showed how the proportion of patients with hospitalizations was significantly reduced after GeneSight testing,” said Dale Muzzey, chief scientific officer, Myriad Genetics.
  • We expect to share additional study results later this year.”
    The study demonstrated that the percentage of patients with hospitalizations was significantly reduced 180 days after GeneSight testing:
    39% relative reduction in psychiatric-related hospitalizations.
  • Significant reduction in hospitalizations for patients who were switched to a medication with no or moderate gene-drug interactions.

23andMe to Present Data on Two Clinical Stage Immuno-Oncology Programs at the American Association for Cancer Research (AACR) Annual Meeting 2024

Retrieved on: 
Friday, April 5, 2024

Data also show soluble ULBP6 is a dominant immunosuppressor compared to other soluble NKG2D ligands due to its highest binding affinity to NKG2D among all NKG2D ligands.

Key Points: 
  • Data also show soluble ULBP6 is a dominant immunosuppressor compared to other soluble NKG2D ligands due to its highest binding affinity to NKG2D among all NKG2D ligands.
  • ULBP6 is a stress-induced ligand that is upregulated on the surface of cancer cells and binds to the activating immunoreceptor NKG2D found on NK and T cells.
  • The presentations will be available on the 23andMe Investor Relations and Therapeutics websites on April 8, 2024.
  • Title: 23ME-01473, a novel anti-ULBP6/2/5 monoclonal antibody, reinvigorates anti-tumor NK cell function through NKG2D and FcγRIIIa activation

QIAGEN strengthens its portfolio for cancer research, showcasing latest product launches at AACR Annual Meeting 2024

Retrieved on: 
Wednesday, April 3, 2024

Two Exhibitor Spotlight Theater sessions and several poster presentations will highlight additional advances from QIAGEN in this field.

Key Points: 
  • Two Exhibitor Spotlight Theater sessions and several poster presentations will highlight additional advances from QIAGEN in this field.
  • EGFR and BRAF are genes essential for normal cell growth and function, but mutations in these genes can result in cancer development.
  • To advance research on how the immune system interacts with cancer, QIAGEN has introduced the QIAseq Targeted RNA-seq Panel for T-cell receptors.
  • Learn more about QIAGEN’s offering at the AACR Annual Meeting 2024, (booth #922 in the San Diego Convention Center) and poster presentations highlighting new solutions in digital PCR, NGS and preanalytical workflows at https://www.qiagen.com/applications/cancer-research/aacr-2024-annual-mee... .

Mello Wins Awards and Accolades for Flower and Retail Location at NECANN Boston

Retrieved on: 
Wednesday, April 3, 2024

Additionally, the Company’s retail location, Mello, located in Haverhill, has received a revered five-star rating from the NECANN Cup for quality service, an extensive product selection, and a friendly atmosphere.

Key Points: 
  • Additionally, the Company’s retail location, Mello, located in Haverhill, has received a revered five-star rating from the NECANN Cup for quality service, an extensive product selection, and a friendly atmosphere.
  • Mello is a cannabis cultivator and retailer located in Haverhill, MA, the company’s founders have more than 25 years of experience breeding cannabis, cultivating flower, and educating customers.
  • “Space Candy,” the cultivar that won Mello third place in the NECANN cup, is one of the Company’s newest signature strains.
  • To purchase the Company’s award-winning flower and experience their five-star dispensary, visit Mello in person at 330 Amesbury Rd in Haverhill, MA.