Researchers Find New Pathway for HIV Invasion of Cell Nucleus
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Thursday, August 10, 2023
Infection, Metastasis, DNA, Drug development, Osteopathic medicine in the United States, HIV, Princess Haya Biotechnology Center, Nature Communications, Cancer, Viral, Research, Cell, BIOTEC, Protein, MD, Pathology, Touro University, Touro College of Osteopathic Medicine, Health, Virus, RAB7A, Alzheimer's disease, Disease, Vaccine, Pharmaceutical industry, AIDS
HENDERSON, Nev., Aug. 10, 2023 /PRNewswire/ -- A study published August 10, 2023 in the journal Nature Communications has identified a new pathway that human immunodeficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells.
Key Points:
- HIV infection requires the virus to enter a cell and gain access to the well-guarded nucleus in order for the viral components to be integrated into the healthy cell's DNA.
- But how the viruses get past the protective membrane is not well understood and is the subject of much debate.
- The newly identified pathway begins with HIV entering a cell wrapped inside a membrane package, called an endosome.
- The researchers observed that, in the presence of these molecules, HIV replication does not occur.