Physiology

Mark Watkins Enhances His Celebrated Saxophone Quartet with "FOUR + Six," to Be Released March 29 on Jazz Hang Records

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Thursday, February 29, 2024
Desire, With Friends Like These, Multimedia, Chemistry, BYU, Bass, Inside, Executioner, Prejudice, Physiology, PLUS, Disability, North Dakota State University, Brigham Young, Family, Teaching, Friends, Rock, FOUR, Development, Music, Brigham Young University, Vincent Gardner, Book

RICHMOND, Calif., Feb. 29, 2024 /PRNewswire-PRWeb/ -- Mark Watkins envelops his long-running saxophone quartet in lush, billowing textures on "FOUR + Six," the band's deliriously tuneful sixth album, set for a March 29 release on Jazz Hang Records. Watkins augments the core quartet of himself (soprano and tenor saxes), Sandon Mayhew (tenor sax), Ray Smith (alto sax), and Jon Gudmundson (baritone sax) with Corey Christiansen (guitar); a three-piece rhythm section of Justin Nielsen (piano), Braun Khan (bass), and Kobie Watkins (no relation, drums); and the esteemed Gardner brothers, Derrick (trumpet) and Vincent (trombone).

Key Points: 
  • RICHMOND, Calif., Feb. 29, 2024 /PRNewswire-PRWeb/ -- Mark Watkins envelops his long-running saxophone quartet in lush, billowing textures on "FOUR + Six," the band's deliriously tuneful sixth album, set for a March 29 release on Jazz Hang Records.
  • I love composing for a cappella saxophone quartet but have often been intrigued by the possibility of including a trumpet, a trombone, and a rhythm section in my compositions.
  • These instruments add color and variety to the quartet without creating the weight of a big band.
  • But when a colleague suggested that they investigate some jazz tunes, the Hard-Bop Saxophone Quartet was born.

Open Education Pioneer Taps Educational Video Platform to Boost Student Engagement; Increase Access to High-Quality Learning Materials

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Thursday, February 29, 2024
Trigonometry, Concept, Bloomberg, Partnership, Algebra, Curriculum, Learning, Business ethics, Textbook, OpenStax, History, Physiology, Education, Anatomy, Student, Tutoring

BOSTON, Feb. 29, 2024 /PRNewswire/ -- Boclips, the world's largest curated educational video distribution platform, today announced a new initiative designed to boost student engagement in college and high school courses using OpenStax high quality resources. Thanks to a new partnership with the social annotation platform Perusall, educators nationwide can now access Boclips' rich library of videos and podcasts aligned to OpenStax resources across a wide range of academic subjects.

Key Points: 
  • Using Perusall's platform, educators can annotate text, create assignments, ask students questions, and monitor engagement with material and videos to facilitate a more engaging learning experience.
  • "Today, it's more important than ever to find creative ways to expand access to video content that is relevant, accessible, and curated to suit a given curriculum.
  • Perusall shares our vision of expanding access to high-quality learning materials, and we look forward to collaborating with them in support of educators and learners nationwide."
  • He continues, "This partnership underscores our commitment to serving the needs and preferences of the students and instructors we serve."

San Diego Zoo Wildlife Alliance and China Wildlife Conservation Association Sign a New Cooperative Agreement for Giant Panda Collaboration

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Thursday, February 22, 2024
SAN, Intake, Insemination, Genetics, San Diego Zoo, Physiology, Conservation science, Health, Climate change, GPS, Reproduction, Survival, Science, Partnership

SAN DIEGO, Feb. 22, 2024 /PRNewswire/ -- San Diego Zoo Wildlife Alliance (SDZWA) took an important step forward in having giant pandas return to the San Diego Zoo by signing a cooperative agreement with China Wildlife Conservation Association and filing a permit application with the U.S. Fish and Wildlife Service.

Key Points: 
  • SAN DIEGO, Feb. 22, 2024 /PRNewswire/ -- San Diego Zoo Wildlife Alliance (SDZWA) took an important step forward in having giant pandas return to the San Diego Zoo by signing a cooperative agreement with China Wildlife Conservation Association and filing a permit application with the U.S.
  • SDZWA has a nearly 30-year conservation partnership with research collaborators in China focused on protecting and recovering giant pandas.
  • As such, San Diego Zoo Wildlife Alliance is taking important steps to ensure we are prepared for a potential return.
  • San Diego Zoo Wildlife Alliance is uniquely positioned to collaborate toward a shared goal of creating a sustainable future for giant pandas."

National Geographic Society Launches the Wildlife Intelligence Project

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Wednesday, February 21, 2024
Ecology, Bee, Dolphin, Neuroscience, Research, Intelligence, Lab, Culture, Animal, Cantor, Oregon State University, Physiology, Nature, Empathy, University, Society, Behavior, National Geographic Society, Cooperation, Royal Geographical Society, Cognition, Chimpanzee, Templeton Prize, UN, Felicity, National Geographic, Human, Environment, Hunting

WASHINGTON, Feb. 21, 2024 /PRNewswire/ -- The National Geographic Society announced today the launch of the Wildlife Intelligence Project, an initiative that will fund and follow three National Geographic Explorers as they embark on animal cognition and behavior research that will potentially adapt how humans view, interact and connect with wildlife.

Key Points: 
  • Inspired by Dr. Jane Goodall and the Templeton Prize, the research initiative will support three National Geographic Explorers as they seek to uncover critical insights into animal behavior
    WASHINGTON, Feb. 21, 2024 /PRNewswire/ -- The National Geographic Society announced today the launch of the Wildlife Intelligence Project , an initiative that will fund and follow three National Geographic Explorers as they embark on animal cognition and behavior research that will potentially adapt how humans view, interact and connect with wildlife.
  • "We are proud to launch the Wildlife Intelligence Project and to support and empower the next generation of scientists committed to furthering Dr. Goodall's legacy of inspiring people to take action to protect the wonder of our world," said Ian Miller, Chief Scientist and Innovation Officer, National Geographic Society.
  • We are pleased to be partnering with the National Geographic Society on the Wildlife Intelligence Project and look forward to seeing what new insights we can gain."
  • The work being done by the recipients of the Wildlife Intelligence Project is essential to developing a better understanding of human-animal behavior and the healthy functioning of our planet.

Healthy Foods Deliver Defense Against Cancer and Heart Disease

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Wednesday, February 21, 2024
Buffalo, Blood pressure, Diabetes, Breast cancer, Consumer, Effect, Copper, Research, Magnesium, Zinc, Cholesterol, Blood, Obesity, Mineral, Food, Vitamin, Weight loss, Glycemic, Prostate, Plant, Harvard University, Purdue University, Conditional sentence, Exercise, Plaque, Human body weight, Phytosterol, Niacin, Risk, Potassium, Vitamin E, Seed, Types of plant oils, Radiation, Olive oil, Health, Folate, University, Death, Nutrient, Fasting, Medicine, Artery, Physiology, Heart, Resveratrol, Food industry, Pinterest, Meal, Brain, Fats, HDL, Cancer, Randomized controlled trial, Dietary supplement

The vitamins and minerals in "good-for-you" nourishment provide energy for daily living, help the body grow and repair and can prevent diet-related illnesses like cancer and heart disease.

Key Points: 
  • The vitamins and minerals in "good-for-you" nourishment provide energy for daily living, help the body grow and repair and can prevent diet-related illnesses like cancer and heart disease.
  • According to the Centers for Disease Control and Prevention, heart disease is the leading cause of death in the United States, followed by cancer.
  • There are a number of factors that can increase the risk of developing heart disease, including high blood pressure, high cholesterol, obesity and diabetes .
  • Research shows that in addition to inhibiting colon, prostate and breast cancer cell growth, they can also protect against heart disease.

Lundquist Institute Investigator Dr. Loren Miller to Receive 2024 Top Ten Clinical Research Achievement Award from the Clinical Research Forum

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Thursday, February 15, 2024
Infection, Human services, Chlorhexidine, Paris Las Vegas, University of California, Irvine, Nursing, TLI, Harbor–UCLA Medical Center, Physiology, Agency, Conference, Disease, Interim, Health, Tufts University, University, UC, MPH, Clinical trial, Diagnosis, Science, UCLA, Nose, Pharmaceutical industry

Los Angeles, California, Feb. 14, 2024 (GLOBE NEWSWIRE) -- The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (TLI) is pleased to announce that Lundquist Investigator Loren Miller, MD, MPH will be honored with a 2024 Top Ten Clinical Research Achievement Award

Key Points: 
  • Los Angeles, California, Feb. 14, 2024 (GLOBE NEWSWIRE) -- The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (TLI) is pleased to announce that Lundquist Investigator Loren Miller, MD, MPH will be honored with a 2024 Top Ten Clinical Research Achievement Award
    by the Clinical Research Forum (CR Forum) at a ceremony in Las Vegas, NV on April 2, 2024.
  • The Top 10 Clinical Research Achievement Awards honor groundbreaking achievements in clinical research nationwide.
  • The award recognizes the Protect Trial, a clinical trial jointly led by Dr. Miller and senior investigator Susan Huang, MD, MPH, Chancellor’s Professor at the University of California, Irvine.
  • “I am pleased to congratulate Dr. Loren Miller on receiving this prestigious award from the Clinical Research Forum,” said Dr. Marianne Gausche-Hill, Interim President and CEO of The Lundquist Institute.

Reflection paper on investigation of pharmacokinetics in the obese population - Scientific guideline

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Wednesday, February 14, 2024
Leptin, PD, Metabolism, Toxicity, Body composition, Ciprofloxacin, Clinical Pharmacokinetics, Water, LBW, Perfusion, LBM, Canadian International Council, AUC, PLOS One, Bariatric surgery, Clopidogrel, CYP, Breast, Health, DNA-binding protein, BMC Public Health, Pharmacology, BMI, CRP, Pharmaceutical Research (journal), Organ, Draft, Guideline, Bypass surgery, WHO, Ageing, INT, Pharmacokinetics, Liver, Bioavailability, Chronic liver disease, Human, Incidence, Committee, Absorption, TBW, Cardiovascular disease, Anatomy, CYP2C19, PBPK, Cmax, Factorization of polynomials, European, Lancet, CHMP, Journal, NASH, Pharmacotherapy, Adipose tissue, Non-alcoholic fatty liver disease, Journal of Clinical Investigation, Medication package insert, Overweight, NPS MedicineWise, Permeability, Benzodiazepine, Meta-analysis, Liver disease, Half-life, Acetylcholine, Ciclosporin, AAG, Kinetics, Midazolam, Kidney, Safety, Biomarker, Clinical Pharmacology & Therapeutics, Peptide, Classification, Hypertension, Metabolic syndrome, Acute coronary syndrome, Insulin resistance, Fatty liver disease, CYP2E1, Lithium, Body mass index, Reproduction, EMA, IBW, Injection, Anker, NCA, Enzyme, Inflammation, Cancer, Weight loss, Gastrointestinal tract, Cardiac output, Public health, Adipokine, CYP2C9, E pluribus unum, Physiology, Agency, Risk, Steroid, Lymph, CYP2D6, BSA, GI, Cytokine, Systematic review, Vaccine

Reflection paper on investigations of pharmacokinetics in

Key Points: 
    • Reflection paper on investigations of pharmacokinetics in
      the obese population
      Table of contents
      1.
    • References .............................................................................................. 9

      Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

      Page 2/12

      1.

    • This is considered
      a shortcoming that is potentially compounded by obese patients often being poorly represented in
      clinical studies.
    • The specific aims of this reflection paper are to:
      ?

      describe how the effects of obesity can be investigated during clinical medicinal product
      development.

    • ?

      provide recommendations on when investigations of the effect of obesity on the PK of a
      medicinal product should be particularly considered.

    • Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

      Page 3/12

      ?

      discuss how to reflect PK (and/or PK/PD) findings in weight/weight-based dosing
      recommendations.

    • Absorption
      Reduced rate of absorption linked to locally reduced blood flow (8) is reported for the subcutaneous
      and transdermal routes in obese subjects.
    • Distribution
      The distribution of medicinal products is driven by body composition, regional blood flow and binding to
      tissue and plasma proteins.
    • Obese subjects have a larger absolute lean body weight (LBW) as well as fat mass.
    • The physicochemical properties of a medicinal product (lipophilicity, polarity, molecular size, and
      degree of ionization) influence its distribution in the body.
    • In BMI class III obese
      subjects, the blood flow per gram of fat is significantly lower than that observed in class I obese or
      lean subjects (4).
    • Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

      Page 4/12

      An increased amount of alpha-1-acid-glycoprotein (AAG), linked to a chronic inflammatory state, is
      reported in obese individuals.

    • Fatty infiltrations are present in the liver for 90% of obese subjects, with the extent of the infiltrations
      being proportional to the degree of obesity.
    • In some cases, in particular for CYP3A4 metabolized medicinal products,
      bodyweight normalized clearance can be lower in obese patients (23).
    • Based on presently available data, it has been suggested that uptake transporters

      Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

      Page 5/12

      are downregulated while efflux transporters may be upregulated (31).

    • Platelet hyper-reactivity is also observed,
      which can impair the response to anti-platelet medicinal products in obese patients (42, 43).
    • Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

      Page 6/12

      3.

      the medicinal product properties and scientific literature indicate that obesity may lead to a
      marked effect on elimination and/or distribution or on the PK/PD relationship.

    • These
      models may aid in extrapolating the known efficacy and safety in the non-obese population to the
      obese population.
    • The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients
      Before and One Year After Bariatric Surgery.
    • Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

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      41.

    • Reflection paper on investigations of pharmacokinetics in the obese population
      EMA/CHMP/535116/2016

      Page 12/12

Europe Cell-Based Assay Market Analysis and Forecast Report 2023-2032 Featuring Merck KGaA and Lonza Group with Focus on Emerging Technologies and Applications - ResearchAndMarkets.com

Retrieved on: 
Tuesday, February 13, 2024
Health, Biotechnology, Prevalence, Conditional sentence, CRISPR, Drug discovery, Toxicity, Benchmarking, Government, Physiology, Investment

The "Europe Cell-Based Assay Market: Analysis and Forecast, 2023-2032" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Europe Cell-Based Assay Market: Analysis and Forecast, 2023-2032" report has been added to ResearchAndMarkets.com's offering.
  • This trend is further amplified by rising chronic disease prevalence and supportive government initiatives, fostering a market poised for significant expansion.
  • The European cell-based assay market is experiencing a surge, fueled by a confluence of factors.
  • The Europe cell-based assay market is anticipated to witness growth during the forecast year 2023-2032.

Ax-3 Astronauts Splashdown, Completing First All-European Commercial Astronaut Mission to ISS

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Friday, February 9, 2024
International Space Station, ESA, Axiom Space, Axiom, UK Space Agency, Government, Axiom Orbital Segment, European Space Agency, SpaceX Dragon, Australian Space Agency, Organization, Mission, Environment, Research, Physiology, NASA, Kennedy Space Center, ISS, Communications satellite

The Ax-3 crew's return officially concludes the first all-European commercial astronaut mission and Axiom Space's third crewed mission to the ISS.

Key Points: 
  • The Ax-3 crew's return officially concludes the first all-European commercial astronaut mission and Axiom Space's third crewed mission to the ISS.
  • Ax-3 demonstrates that the European community of space-faring nations are pioneers in the burgeoning commercial space industry.
  • Ax-3 celebrates many firsts: it was the first commercial spaceflight mission comprised of government and ESA-sponsored national astronauts; Mission Specialist Alper Gezeravcı became the first-ever Turkish astronaut; and Mission Specialist Marcus Wandt was the first ESA project astronaut to fly on a commercial space mission.
  • Axiom Space plans to launch its fourth mission, Axiom Mission 4 (Ax-4) , to the ISS no earlier than October 2024 from NASA's Kennedy Space Center in Florida.

Better Blend: Smoothie Shop is Dietician Approved

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Thursday, February 8, 2024
Physiology, Weight loss, Ice cream, Health, Private practice, Metabolism, Multimedia, Blend, Food, SlimFast

Better Blend's mission is to make the world a healthier and happier place by making it easy to eat healthy.

Key Points: 
  • Better Blend's mission is to make the world a healthier and happier place by making it easy to eat healthy.
  • Through this growth spurt, Better Blend caught the attention of Loveland, OH dietician, Emily Mobley of Gray Nutrition.
  • Emily's expertise and passion for easy-to-digest nutrition advice made her a perfect fit on the Better Blend team as their in-house dietician.
  • As featured on Better Blend's Dietician Tuesday series, Emily provides Better Blend customers with helpful nutrition tips and further information about the benefits of Better Blend products.