Nose

In Knife, his memoir of surviving attack, Salman Rushdie confronts a world where liberal principles like free speech are old-fashioned

Retrieved on: 
Friday, April 19, 2024

A man named Hadi Matar has been charged with second-degree attempted murder.

Key Points: 
  • A man named Hadi Matar has been charged with second-degree attempted murder.
  • He is an American-born resident of New Jersey in his early twenties, whose parents emigrated from Lebanon.
  • Review: Knife: Meditations After an Attempted Murder – Salman Rushdie (Jonathan Cape) Knife is very good at recalling Rushdie’s grim memories of the attack.
  • “Let me offer this piece of advice to you, gentle reader,” he says: “if you can avoid having your eyelid sewn shut … avoid it.
  • Here, for a number of reasons, Rushdie is not on such secure ground.
  • Read more:
    How Salman Rushdie has been a scapegoat for complex historical differences

    Rushdie, who studied history at Cambridge University, described himself in Joseph Anton as “a historian by training”.

  • Indeed, a speech he gave at PEN America in 2022 is reprinted in the book verbatim.
  • For these intellectuals, principles of secular reason and personal liberty should always supersede blind conformity to social or religious authority.

Old-fashioned liberal principles

  • In Knife, though, Rushdie the protagonist confronts a world where such liberal principles now appear old-fashioned.
  • He claims “the groupthink of radical Islam” has been shaped by “the groupthink-manufacturing giants, YouTube, Facebook, Twitter”.
  • But for many non-religious younger people, any notion of free choice also appears illusory, the anachronistic residue of an earlier age.
  • Millennials and Generation Z are concerned primarily with issues of environmental catastrophe and social justice, and they tend to regard liberal individualism as both ineffective and self-indulgent.
  • A new book traces how we got here, but lets neoliberal ideologues off the hook

Suffused in the culture of Islam

  • The Satanic Verses itself is suffused in the culture of Islam as much as James Joyce’s Ulysses is suffused in the culture of Catholicism.
  • In their hypothetical conversation, the author of Knife tries to convince his assailant of the value of such ambivalence.
  • He protests how his notorious novel revolves around “an East London Indian family running a café-restaurant, portrayed with real love”.

Attachment to past traditions

  • Rushdie discusses in Knife how, besides the Hindu legends of his youth, he has also been “more influenced by the Christian world than I realized”.
  • He cites the music of Handel and the art of Michelangelo as particular influences.
  • Yet this again highlights Rushdie’s attachments to traditions firmly rooted in the past.
  • Part of James’s greatness lay in the way he was able to accommodate these radical shifts within his writing.

‘A curiously one-eyed book’

  • Particularly striking are the immediacy with which he recalls the shocking assault, the black humour with which he relates medical procedures and the sense of “exhilaration” at finally returning home with his wife to Manhattan.
  • Yet there are also many loose ends, and the book’s conclusion, that the assailant has in the end become “simply irrelevant” to him, is implausible.
  • He insists he does not want to write “frightened” or “revenge” books.
  • This was despite several brave comeback attempts by Milburn that likewise cited Pataudi as an example.
  • Knife, by contrast, is a curiously one-eyed book, in a metaphorical, as well as a literal sense.


Paul Giles does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

How your vision can predict dementia 12 years before it is diagnosed – new study

Retrieved on: 
Wednesday, April 10, 2024

Our latest study shows that a loss of visual sensitivity can predict dementia 12 years before it is diagnosed.

Key Points: 
  • Our latest study shows that a loss of visual sensitivity can predict dementia 12 years before it is diagnosed.
  • Our research was based on 8,623 healthy people in Norfolk, England, who were followed up for many years.
  • By the end of the study, 537 participants had developed dementia, so we could see what factors might have preceded this diagnosis.
  • People who would develop dementia were much slower to see this triangle on the screen than people who would remain without dementia.

Recognising faces

  • We have some evidence which suggests that people with dementia tend to process new people’s faces inefficiently.
  • In other words, they don’t follow the usual pattern of scanning the face of the person they are talking to.
  • So this early issue in not recognising people you have just met could be related to ineffective eye movement for new faces, rather than being a pure memory disorder.

Can eye movement improve memory?

  • Previous research on the matter is mixed, but some studies found that eye movement can improve memory.
  • In other studies, eye movements from left to right and right to left done quickly (two eye movements per second) were found to improve autobiographical memory (your life story).
  • Also, using deficits in eye movements as a diagnostic is not a regular feature, despite the possibilities in eye movement technology.


Eef Hogervorst receives funding from the Dunhill Medical Trust [email protected] receives funding from Road Safety Trust. He is affiliated with Applied Vision Association. Ahmet Begde does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Infections after surgery are more likely due to bacteria already on your skin than from microbes in the hospital − new research

Retrieved on: 
Wednesday, April 10, 2024

Genetic data from the bacteria causing these infections – think CSI for E. coli – tells another story: Most health care-associated infections are caused by previously harmless bacteria that patients already had on their bodies before they even entered the hospital.

Key Points: 
  • Genetic data from the bacteria causing these infections – think CSI for E. coli – tells another story: Most health care-associated infections are caused by previously harmless bacteria that patients already had on their bodies before they even entered the hospital.
  • We show that many surgical site infections after spinal surgery are caused by microbes that are already on the patient’s skin.

Surgical infections are a persistent problem

  • Among the different types of heath care-associated infections, surgical site infections stand out as particularly problematic.
  • A 2013 study found that surgical site infections contribute the most to the annual costs of hospital-acquired infections, totaling over 33% of the US$9.8 billion spent annually.
  • Still, surgical site infections occur following about 1 in 30 procedures, typically with no explanation.
  • While rates of many other medical complications have shown steady improvement over time, data from the Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention show that the problem of surgical site infection is not getting better.

BYOB (Bring your own bacteria)

  • Prior studies on surgical site infection have been limited to a single species of bacteria and used older genetic analysis methods.
  • But new technologies have opened the door to studying all types of bacteria and testing their antibiotic resistance genes simultaneously.
  • Over a one-year period, we sampled the bacteria living in the nose, skin and stool of over 200 patients before surgery.
  • In fact, 86% of the bacteria causing infections after spine surgery were genetically matched to bacteria a patient carried before surgery.
  • That number is remarkably close to estimates from earlier studies using older genetic techniques focused on Staphylococcus aureus.
  • They likely acquired these antibiotic-resistant microbes through prior antibiotic exposure, consumer products or routine community contact.

Preventing surgical infections

  • At face value, our results may seem intuitive – surgical wound infections come from bacteria that hang out around that part of the body.
  • If the most likely source of surgical infection – the patient’s microbiome – is known in advance, this presents medical teams with an opportunity to protect against it prior to a scheduled procedure.
  • The fact that most infections don’t actually start with sources in the hospital is probably a testament to the efficacy of these protocols.


Dustin Long receives funding from the National Institutes of Health. Dr Bryson-Cahn receives funding from the Gordon and Berry Moore Foundation and is the co-medical director for Alaska Airlines.

Optinose to Present at the Needham Virtual Healthcare Conference

Retrieved on: 
Thursday, April 4, 2024

YARDLEY, Pa., April 04, 2024 (GLOBE NEWSWIRE) -- Optinose (NASDAQ:OPTN), a pharmaceutical company focused on patients treated by ear, nose and throat (ENT) and allergy specialists, today announced that members of its management team will present a company overview and business update at the Needham Virtual Healthcare Conference on April 10, 2024 at 2:15 p.m.

Key Points: 
  • YARDLEY, Pa., April 04, 2024 (GLOBE NEWSWIRE) -- Optinose (NASDAQ:OPTN), a pharmaceutical company focused on patients treated by ear, nose and throat (ENT) and allergy specialists, today announced that members of its management team will present a company overview and business update at the Needham Virtual Healthcare Conference on April 10, 2024 at 2:15 p.m.
  • ET.
  • To listen to a webcast of the presentation live, please visit the Investors page of the Optinose website.
  • A replay of the webcast will be available for 30 days following the conclusion of the event.

Integra LifeSciences Completes the Acquisition of Acclarent, Inc.

Retrieved on: 
Monday, April 1, 2024

PRINCETON, N.J., April 01, 2024 (GLOBE NEWSWIRE) -- Integra LifeSciences Holdings Corporation (NASDAQ:IART), a leading global medical technology company, today announced it has successfully completed its acquisition of Acclarent, Inc. , a pioneer in ear, nose and throat (ENT) surgical interventions.

Key Points: 
  • PRINCETON, N.J., April 01, 2024 (GLOBE NEWSWIRE) -- Integra LifeSciences Holdings Corporation (NASDAQ:IART), a leading global medical technology company, today announced it has successfully completed its acquisition of Acclarent, Inc. , a pioneer in ear, nose and throat (ENT) surgical interventions.
  • The addition of Acclarent's innovative product portfolio expands the breadth of Integra’s market-leading brands and provides immediate scale and accretive growth via a dedicated sales channel.
  • The acquisition adds $1 billion to the total addressable market of the Company’s offerings, while providing unique market opportunities for access to the attractive ENT device segment.
  • A webcast replay of the conference call will be posted on the investor section of the Company’s website following the call.

Spirair Receives FDA Clearance for SeptAlign, the First and Only Minimally Invasive Therapy for Mechanical Correction of Nasal Septal Deviation

Retrieved on: 
Monday, April 8, 2024

This comes on the heels of FDA clearance of the SeptAlign bioabsorbable Implant in August 2023 and represents the final step in completing the FDA clearance process for the SeptAlign System.

Key Points: 
  • This comes on the heels of FDA clearance of the SeptAlign bioabsorbable Implant in August 2023 and represents the final step in completing the FDA clearance process for the SeptAlign System.
  • "Septal deviation is one of the primary contributors to nasal airway obstruction.
  • Physicians can't move septal cartilage with medicines so mechanical correction through surgery has been the best choice for many patients.
  • Following the clearance of the SeptAlign system, Spirair plans to begin a Series B fundraising round and start commercialization.

Rabbit Hole Distillery Unveils Founder's Collection Limited-Release Mizunara

Retrieved on: 
Tuesday, April 9, 2024

LOUISVILLE, Ky., April 9, 2024 /PRNewswire/ -- Rabbit Hole Distillery today announced the second release of Mizunara, a remarkable 15-year-old Kentucky straight bourbon whiskey finished in the world's most elusive barrels crafted from Japanese Mizunara Oak. Mizunara is the latest addition to the brand's highly coveted Founder's Collection.

Key Points: 
  • Mizunara is the latest addition to Rabbit Hole Distillery's highly coveted Founder's Collection.
  • For this limited release, Rabbit Hole Distillery Founder and Kentucky Bourbon Hall of Fame Whiskey Maker, Kaveh Zamanian, selected a handful of 15-year-old whiskey barrels from his own personal collection and finished them in these special Japanese Mizunara Oak barrels, revealing a remarkable, one-of-a-kind whiskey.
  • Today, only 2,200 bottles of Mizunara are available for purchase at Rabbit Hole Distillery and in select markets nationwide.
  • For more information about Rabbit Hole Distillery, visit www.rabbitholedistillery.com and follow along on social media @rabbithole.

Lux Row Distillers Introduces Ezra Brooks 99 Port Wine Cask Finish

Retrieved on: 
Tuesday, April 9, 2024

ST. LOUIS , April 9, 2024 /PRNewswire/ -- Lux Row Distillers announced the latest addition to the Ezra Brooks brand family: Ezra Brooks 99 Port Wine Cask Finish. Finished in port casks from Portugal for six months, Ezra Brooks 99 Port Wine Cask Finish delivers the great spicy ryed bourbon taste and smooth finish Ezra Brooks is known for in its already bold 99 proof bourbon, with additional flavor notes. The new variant will start shipping to retailers later this month at a suggested retail price of $34.99 per 750 ml bottle.

Key Points: 
  • ST. LOUIS , April 9, 2024 /PRNewswire/ -- Lux Row Distillers announced the latest addition to the Ezra Brooks brand family: Ezra Brooks 99 Port Wine Cask Finish.
  • Finished in port casks from Portugal for six months, Ezra Brooks 99 Port Wine Cask Finish delivers the great spicy ryed bourbon taste and smooth finish Ezra Brooks is known for in its already bold 99 proof bourbon, with additional flavor notes.
  • With a mash bill of 78% corn, 10% rye and 12% malt, Ezra Brooks 99 Port Wine Cask Finish is distilled using the highest quality ingredients, aged the old-fashioned way and bottled at 99 proof (49.5% ABV).
  • "We created Ezra Brooks 99 Port Wine Cask Finish for bourbon fans looking for an elevated taste profile and unique flavor option," said Eric Winter, Ezra Brooks brand manager.

Marchesi Frescobaldi releases 2023 vintage of Tenuta Ammiraglia ALÌE

Retrieved on: 
Tuesday, April 9, 2024

MAGLIANO, Italy, April 9, 2024 /PRNewswire-PRWeb/ -- 2023 marks a true milestone for Alìe: its 10th vintage. The first, released in 2014, was reason enough for celebration, but for the current release, Marchesi Frescobaldi is celebrating its rosé by dedicating to it a poetic piece: the Alìade.

Key Points: 
  • The rosé in question is the icon of Tenuta Ammiraglia, on Tuscany's Maremma coast, a blend of the international Syrah and the native Vermentino grape.
  • "Here on the Tenuta Ammiraglia, the vineyards design intriguing geometrical shapes across the hillslopes as they descend to the waters of the Tyrrhenian Sea.
  • Today, we regard with great pride the decision we made to produce these two rosés, Cru Aurea Gran Rosé and Alìe.
  • Marchesi Frescobaldi's nine wine estates are: Castello Pomino (Pomino), Castello Nipozzano (Nipozzano), Tenuta Perano (Gaiole in Chianti), Tenuta Castiglioni (Montespertoli), Tenuta CastelGiocondo (Montalcino), Tenuta Ammiraglia (Magliano in Toscana), Remole (Sieci), Tenuta Calimaia (Montepulciano), and Gorgona.

Orphan designation: Allogeneic cultured postnatal thymus-derived tissue Treatment of CHARGE syndrome, 26/02/2019 Positive

Retrieved on: 
Tuesday, April 9, 2024

Orphan designation: Allogeneic cultured postnatal thymus-derived tissue Treatment of CHARGE syndrome, 26/02/2019 Positive

Key Points: 


Orphan designation: Allogeneic cultured postnatal thymus-derived tissue Treatment of CHARGE syndrome, 26/02/2019 Positive