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Motus GI Holdings Publishes Positive Results from a European Study of the Second Generation Pure-Vu System in Improving Visualization for Colonoscopy in Patients with a History of Poor Bowel Preparation

Retrieved on: 
Tuesday, January 30, 2024

The Company’s Pure-Vu System is an FDA-approved and CE-certified bowel cleansing system (BCS) intended to increase visualization in inadequately prepared colons by offering intraprocedural cleansing.

Key Points: 
  • The Company’s Pure-Vu System is an FDA-approved and CE-certified bowel cleansing system (BCS) intended to increase visualization in inadequately prepared colons by offering intraprocedural cleansing.
  • “We are excited to see the positive results from this European study published in the UGE Journal, further building upon the extensive portfolio of study data and user experiences for the second generation Pure-Vu System.
  • This study concluded that adequate bowel cleaning can be achieved in patients with a history of inadequate bowel preparation by using the Pure-Vu System.
  • The study enrolled a total of 44 patients with previous poor bowel preparation (BBPS

Dassi Erlich and her sisters were ‘easy pickings for predators’. With their abuser Malka Leifer’s conviction – and a new book – they take control

Retrieved on: 
Tuesday, January 30, 2024

Last year, after a 15-year campaign, her abuser, Malka Leifer, who had fled to Israel, was tried and sentenced, convicted of 18 charges of sexual abuse against Erlich and her sister, Elly.

Key Points: 
  • Last year, after a 15-year campaign, her abuser, Malka Leifer, who had fled to Israel, was tried and sentenced, convicted of 18 charges of sexual abuse against Erlich and her sister, Elly.
  • (She was acquitted of charges involving a third Erlich sister, Nicole.)
  • But when her need was most acute, Erlich could not have contacted any of these services.

Adass Israel ‘evokes 19th-century Europe’

  • As with most ultra-Orthodox Judaism, Adass Israel originated in 19th-century Europe as a conservative reaction to liberal secularism.
  • The cut of the men’s black silk coats worn with white shirts, and their mink hats, come from that time and place.
  • The Australian congregation was only formed in 1939, but the tiny enclave within East St Kilda and Ripponlea where Melbourne’s Adass Israel community lives effectively evokes 19th-century Europe.
  • Her parents had joined a generation later, as converts to Orthodoxy after emigrating from England.
  • She notes that as a result, “my mother was on a mission to prove her worth to the Adass community”.
  • Erlich writes that from a young age, she realised her mother’s rage “had no rhyme or reason, no trigger we could predict”.
  • The children were punished by being deprived of food and even the ability to go to the toilet at night.
  • Marriages are arranged via matchmakers, and couples have few meetings before their wedding.
  • Erlich writes that the first time she had an unsupervised conversation with her former husband, Shua Erlich, was on their wedding day.
  • Such is the fear of contamination by gender, unrelated girls and boys do not mix after they turn three.

‘It was just a woman’


When Dassi Erlich was in year nine, in December 2002, a new principal was appointed to the girls’ school. Malka Leifer had come from Israel with excellent references and appeared to be everything this devout congregation could desire. Erlich writes of “the respect and awe” the schoolgirls felt in the presence of this charismatic woman, who exuded authority.

  • Her mother was flattered when Leifer offered to give her daughter private lessons out of school hours, to advance her religious education.
  • Erlich wrote of these “lessons” that “I never found my words” to object to the continuing assaults on her body.
  • The account of her inability to escape is hard to read, but is also hard to stop reading.
  • It is hardly surprising the Adass community reacted to the news of the principal’s criminal behaviour in the same way.
  • Her religion controlled every aspect of her life, but could not save her from being raped.
  • It was just a woman.”

    Read more:
    Holy Woman's fleshy, feminist spiritual pilgrimage is a warning against religious coercive control

Unrestrained power, control and authority

  • When Erlich becomes suicidal after the birth of her daughter, her husband’s liberal Jewish father pays for her admission to the Albert Road psychiatric clinic.
  • The end of her marriage was inevitable, as were her many missteps on the way to freedom.
  • In enclosed sects, whatever their complexion, those who leave and speak out against misbehaviour are shunned, often losing all contact with their families.
  • The response of the Orthodox Jewish community to the truths exposed by Erlich and her siblings was as expected.
  • In 2016, a year after the judge in Erlich’s civil case ruled that “Leifer’s appalling misconduct […] was built on this position of unrestrained power, control and authority that had been bestowed on her by the Board”, Adass Israel was the subject of a television documentary, Strictly Jewish.

Global quest for justice

  • Instead, she was released from custody, feigning a mental illness that had turned her into a zombie-like state.
  • The book details the behaviour of Israeli medical, legal and political figures in their efforts to prevent Leifer from facing trial.
  • Jewish politicians, both Liberal and Labor, led their colleagues in supporting the sisters’ quest to bring Malka Leifer to judgement.
  • Erlich’s account of how her predator was eventually brought to justice shows how well these siblings learnt to work with the once unfamiliar outlet of social media.
  • After their Facebook group was trolled by Leifer’s supporters, they established a Twitter thread, #bringleiferback.
  • Although the extradition, trial and conviction of Malka Leifer was a group effort, full credit for bringing her to justice must go to the sisters – Dassi Erlich, Elly Sapper and Nicole Meyer.
  • This is a very self-aware memoir: Erlich and her sisters know they need to take control of their own narrative.


Joanna Mendelssohn has in the past received funding from the Australian Research Council

Journal of the American Academy of Dermatology Publishes ZORYVE (roflumilast) Foam, 0.3% Results for Seborrheic Dermatitis from Pivotal Phase 3 Trial

Retrieved on: 
Monday, January 29, 2024

“Despite being very common, seborrheic dermatitis has traditionally been a disease with limited treatment options.

Key Points: 
  • “Despite being very common, seborrheic dermatitis has traditionally been a disease with limited treatment options.
  • These results highlight the effectiveness and safety of roflumilast foam, a steroid-free treatment and the first novel mechanism of action approved for seb derm in two decades.
  • Roflumilast foam also demonstrated statistically significant improvement over vehicle on all secondary endpoints, including itch, scaling, and erythema (redness).
  • The most common adverse reactions (≥1%) reported, per the prescribing information, include nasopharyngitis (1.5%), nausea (1.3%), and headache (1.1%).

Vital’s Scientific Publication on Sepsis Paves Way for Predictive Analytics Tools

Retrieved on: 
Monday, January 29, 2024

The peer-reviewed paper, " Sepsis Prediction at Emergency Department Triage Using Natural Language Processing: Retrospective Cohort Study ," highlights the power of artificial intelligence (AI) in predicting sepsis at the earliest stages.

Key Points: 
  • The peer-reviewed paper, " Sepsis Prediction at Emergency Department Triage Using Natural Language Processing: Retrospective Cohort Study ," highlights the power of artificial intelligence (AI) in predicting sepsis at the earliest stages.
  • Timely sepsis prediction: The research demonstrates that ML algorithms can accurately predict sepsis at ED presentation, enabling healthcare providers to intervene promptly and enhance patient care.
  • Sepsis was accurately predicted in 76% of septic patients where sepsis screening was not initiated at triage and 98% of cases where sepsis screening was initiated at triage.
  • To coincide with this publication, Vital is announcing future plans to deliver solutions that use predictive analytics to notify physicians and staff about quality and safety issues.

Atlanta University Center (AUC) Library CEO & Director, Loretta Parham to Retire This Year

Retrieved on: 
Thursday, January 25, 2024

ATLANTA, Jan. 25, 2024 /PRNewswire/ -- Loretta Parham, chief executive officer and director of the Robert W. Woodruff Library of the Atlanta University Center Inc., will retire after 19 years of outstanding leadership of the Library.

Key Points: 
  • ATLANTA, Jan. 25, 2024 /PRNewswire/ -- Loretta Parham, chief executive officer and director of the Robert W. Woodruff Library of the Atlanta University Center Inc., will retire after 19 years of outstanding leadership of the Library.
  • The Board of Trustees and governing body of the AUC Woodruff Library is announcing her planned retirement date of June 2024.
  • Parham received her master's degree from the University of Michigan and her bachelor's degree from Southern Illinois University.
  • The Library's Board of Trustees will launch a national executive search for the next AUC Woodruff Library CEO and Director.

Novel AI platform matches cardiologists in detecting rheumatic heart disease

Retrieved on: 
Tuesday, January 16, 2024

RHD is caused by the body’s reaction to repeated Strep A bacterial infections and can cause permanent heart damage.

Key Points: 
  • RHD is caused by the body’s reaction to repeated Strep A bacterial infections and can cause permanent heart damage.
  • This tell-tale sign of the disease causes the mitral valve flaps to close improperly, leading to backward blood flow in the heart.
  • They combined the power of both approaches to optimize the novel algorithm, which is trained to interpret ultrasound images of the heart to detect RHD.
  • Already, the AI algorithm has analyzed 39 features of hearts with RHD that cardiologists cannot detect or measure with the naked eye.

Dawn Bates International Launches Groundbreaking 7 Week Author Course to Empower Aspiring Writers Globally

Retrieved on: 
Friday, January 12, 2024

VANCOUVER, British Columbia, Jan. 12, 2024 (GLOBE NEWSWIRE) -- Dawn Bates International (DBI) takes a bold stand, providing a lifeline for aspiring authors with the launch of their revolutionary 7 Week Author Course.

Key Points: 
  • VANCOUVER, British Columbia, Jan. 12, 2024 (GLOBE NEWSWIRE) -- Dawn Bates International (DBI) takes a bold stand, providing a lifeline for aspiring authors with the launch of their revolutionary 7 Week Author Course.
  • The 7 Week Author Course covers the entire spectrum of authorship, from understanding writing and publishing processes to mastering the business of being an author.
  • DBI invites aspiring authors worldwide to join the movement and embark on a transformative journey with the 7 Week Author Course.
  • For more information and to enroll in the 7 Week Author Course, visit Dawn Bates International - Author Academy .

A UNIVERSAL CORONAVIRUS VACCINE COULD SAVE BILLIONS OF DOLLARS IF READY BEFORE NEXT PANDEMIC

Retrieved on: 
Thursday, January 11, 2024

NEW YORK, Jan. 11, 2024 /PRNewswire/ -- What if scientists had developed a universal coronavirus vaccine in the years prior to 2020 so that it was available at the start of the COVID-19 pandemic? A universal coronavirus vaccine targets parts of the virus that are common to either many or all coronaviruses, thereby offering some degree of protection against a range of strains. A new study suggests if such a vaccine were available at the start of the pandemic, it could have saved millions of lives, prevented suffering, and saved billions of dollars in direct medical and other costs until the strain-specific (i.e., SARS-CoV-2) vaccine went through the entire development, testing, and emergency use authorization process that lasted 10 months.

Key Points: 
  • NEW YORK, Jan. 11, 2024 /PRNewswire/ -- What if scientists had developed a universal coronavirus vaccine in the years prior to 2020 so that it was available at the start of the COVID-19 pandemic?
  • A universal coronavirus vaccine targets parts of the virus that are common to either many or all coronaviruses, thereby offering some degree of protection against a range of strains.
  • The experiments simulated what would happen if a universal coronavirus vaccine was available at the start of the COVID-19 pandemic.
  • A universal coronavirus vaccine was also shown to be highly cost-effective even if a more specific and more efficacious vaccine came to market.

Denali Therapeutics Announces Key Anticipated 2024 Milestones and Priorities to Further Advance Its Therapeutics Portfolio for Neurodegeneration and Lysosomal Storage Diseases

Retrieved on: 
Monday, January 8, 2024

The global Phase 2/3 COMPASS study continues to recruit up to 54 participants with neuronopathic and non-neuronopathic MPS II.

Key Points: 
  • The global Phase 2/3 COMPASS study continues to recruit up to 54 participants with neuronopathic and non-neuronopathic MPS II.
  • Upon completion of the ongoing Phase 1/2 study, and together with data from COMPASS, this combined data package is intended to support registration.
  • Increased RIPK1 activity in the CNS is hypothesized to drive neuroinflammation and cell necroptosis and to contribute to neurodegeneration.
  • Denali will maintain ownership of and continue to advance its current portfolio of clinical stage small molecule programs.

Cartesian Therapeutics Announces Positive Long-Term Follow-Up Data from Phase 2a Study of Lead mRNA Cell Therapy Candidate Descartes-08 in Patients with Myasthenia Gravis

Retrieved on: 
Monday, January 8, 2024

GAITHERSBURG, Md., Jan. 08, 2024 (GLOBE NEWSWIRE) -- Cartesian Therapeutics, Inc. (NASDAQ: RNAC), (“the Company”) a clinical-stage biotechnology company pioneering mRNA cell therapies for autoimmune diseases, today announced positive twelve-month follow-up data from its Phase 2a trial of Descartes-08 in patients with generalized myasthenia gravis (MG), a chronic autoimmune disorder that causes disabling muscle weakness and fatigue. The manuscript titled, “Twelve-Month Follow-Up of Patients With Generalized Myasthenia Gravis Receiving BCMA-Directed mRNA Cell Therapy,” has been submitted for peer-review and can be accessed on the online preprint server, medRxiv.

Key Points: 
  • The manuscript titled, “Twelve-Month Follow-Up of Patients With Generalized Myasthenia Gravis Receiving BCMA-Directed mRNA Cell Therapy,” has been submitted for peer-review and can be accessed on the online preprint server, medRxiv.
  • Descartes-08, Cartesian’s lead mRNA cell therapy candidate and a potential first-in-class mRNA-engineered chimeric antigen receptor T-cell therapy (mRNA CAR-T), is an autologous anti-B-cell maturation antigen (BCMA) mRNA CAR-T.
  • “Notably, most patients maintained robust, clinically meaningful improvements across all four standard MG severity scores approximately 10 months after the last infusion.
  • Enrollment is ongoing in a Phase 2b randomized, double-blind, placebo-controlled trial (NCT04146051) in patients with MG. Topline results are expected in mid-2024.