Model

Kymera Therapeutics Presents Preclinical Data for STAT6 and TYK2 First-In-Class, Oral Degrader Immunology Programs at the American Academy of Dermatology Annual Meeting

Retrieved on: 
Friday, March 8, 2024

WATERTOWN, Mass., March 08, 2024 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of small molecule medicines using targeted protein degradation (TPD), today announced that its preclinical data demonstrating the therapeutic potential of its potent and selective heterobifunctional degraders of STAT6 (KT-621) and TYK2 (KT-294) are being presented in the poster session at the American Academy of Dermatology’s Annual Meeting in San Diego, California. Kymera’s oral STAT6 and TYK2 degraders have the potential to address multiple immune-mediated diseases and overcome the limitations of existing technologies and agents. Today’s poster presentations mark the first time that data from a STAT6 targeted agent and a TYK2 degrader have been shared at a major medical meeting. Based on the results generated to date, Kymera intends to initiate Phase 1 testing for KT-621 and KT-294 in the in the second half of 2024 and the first half of 2025, respectively. Data from both Phase 1 trials are expected to be reported in 2025.

Key Points: 
  • Kymera’s oral STAT6 and TYK2 degraders have the potential to address multiple immune-mediated diseases and overcome the limitations of existing technologies and agents.
  • Today’s poster presentations mark the first time that data from a STAT6 targeted agent and a TYK2 degrader have been shared at a major medical meeting.
  • “Our differentiated strategy to targeted protein degradation has resulted in an industry-leading immunology pipeline of oral degrader medicines, each with the potential to treat multiple complex immuno-inflammatory diseases.
  • At low daily oral doses, preclinical studies with KT-621 demonstrated near full in vivo STAT6 degradation in disease-relevant tissues that was well-tolerated.

Announcing the Establishment of the Technical Support Unit for the IPBES Task Force on Scenarios and Models of Biodiversity and Ecosystem Services in IGES

Retrieved on: 
Friday, March 8, 2024

On Friday 1 March 2024, the Institute for Global Environmental Strategies (IGES), in cooperation with the Ministry of the Environment, Japan, established the Technical Support Unit (TSU) for the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) Task Force on Scenarios and Models of Biodiversity and Ecosystem Services.

Key Points: 
  • On Friday 1 March 2024, the Institute for Global Environmental Strategies (IGES), in cooperation with the Ministry of the Environment, Japan, established the Technical Support Unit (TSU) for the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) Task Force on Scenarios and Models of Biodiversity and Ecosystem Services.
  • The TSU will be located in IGES Tokyo Sustainability Forum (TSF).
  • The IPBES Task Force on Scenarios and Models of Biodiversity and Ecosystem Services is a group of experts established to provide advice and support on scenarios and modelling for various IPBES assessment processes, including the implementation of a programme on scenarios that predict possible future situations for biodiversity and the models used to develop them.
  • IGES expects the task force to provide the scientific information needed to assess progress in implementing the Kunming-Montreal Global Biodiversity Framework, the global biodiversity target for 2030.

Leading Foreign OEMs'ADAS and Autonomous Driving in China Report 2023 - OEMs Build Core Software Capabilities by Strengthening their Software Talent Deployment - ResearchAndMarkets.com

Retrieved on: 
Thursday, February 15, 2024

The "Leading Foreign OEMs'ADAS and Autonomous Driving Report, 2023" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Leading Foreign OEMs'ADAS and Autonomous Driving Report, 2023" report has been added to ResearchAndMarkets.com's offering.
  • Leading foreign OEMs build core software capabilities by strengthening their software talent deployment.
  • For the transition to software-defined vehicles, leading foreign OEMs have increased their investment in software and algorithm talents.
  • 1.1 ADAS Installations and Installation Rate of Foreign Leading OEMs: Overview
    1.2 ADAS Installations and Installation Rate of Foreign Leading OEMs: By Level
    1.3 ADAS Installations and Installation Rate of Foreign Leading OEMs: By Function
    1.5 L2 and Higher-level ADAS Installations and Installation Rate of Foreign Leading OEMs: Overview
    1.6 L2 and Higher-level ADAS Installations and Installation Rate of Foreign Leading OEMs: By Brand
    1.7 L2 and Higher-level ADAS Installation Rate of Foreign Leading OEMs: By Brand
    1.8 L2 and Higher-level ADAS Installations and Installation Rate of Foreign Leading OEMs: By Model
    1.9 L2 and Higher-level ADAS Installations and Installation Rate of Foreign Leading OEMs: By Price
    1.10 L2 and Higher-level ADAS Installation Rate of Foreign Leading OEMs: By Price
    1.11 L2 and Higher-level ADAS Installations of Foreign Leading OEMs: By Price + Model
    1.12 L2.5 and Higher-level ADAS Installations of Foreign Leading OEMs: By Price + Model
    1.13 L2+ ADAS Installations of Foreign Leading OEMs: By Price + Model
    2.1.1 ADAS/AD Software R&D Modes of Foreign Leading OEMs: Case 1
    2.1.2 ADAS/AD Software R&D Modes of Foreign Leading OEMs: Case 2
    2.1.3 ADAS/AD Software R&D Modes of Foreign Leading OEMs: Case 3
    2.1.4 ADAS/AD Software R&D Modes of Foreign Leading OEMs: Case 4
    2.2.1 ADAS/AD Software R&D of Foreign Leading OEMs: SOA Software Development Case 1
    2.2.2 ADAS/AD Software R&D of Foreign Leading OEMs: SOA Software Development Case 2
    2.2.3 ADAS/AD Software R&D of Foreign Leading OEMs: SOA Software Development Case 3
    3.7 L4 Robotaxi Business Layout: Functions and Solutions

Measuring market-based core inflation expectations

Retrieved on: 
Thursday, February 15, 2024

Abstract

Key Points: 
    • Abstract
      We build a novel term structure model for pricing synthetic euro area core inflation-linked
      swaps, a hypothetical swap contract indexed to core inflation.
    • The model provides estimates of market-based expectations for core inflation, as
      well as core inflation risk premia, at daily frequency, whereas core inflation expectations from
      surveys or macroeconomic projections are typically only available monthly or quarterly.
    • We
      find that core inflation-linked swap rates are generally less volatile than headline inflationlinked swap rates and that market participants expected core inflation to be substantially
      more persistent than headline inflation following the 2022 energy price spike.
    • In this paper, we aim to infer market-based core inflation expectations, which are otherwise
      not directly observable because no financial asset directly tied to core inflation exists.
    • We deem this second assumption reasonable because HICP inflation itself is a linear combination
      of core as well as energy and food inflation.
    • The level of 2 percent and relatively low volatility of
      long-term inflation expectations suggests that inflation expectations are firmly anchored at the
      ECB?s 2 percent inflation target.
    • This assumption appears reasonably uncontroversial,
      as core inflation is a sub-component of headline inflation, which the observable headline ILS
      rates are tied to.
    • Our estimates of core ILS rates reflect both market participants? genuine core
      inflation expectations and a core inflation risk premium, but our model explicitly allows for
      this decomposition.
    • The model-implied estimates of core ILS rates appear reasonable along several dimensions:
      (i) like realized core inflation is less volatile than headline inflation, the core ILS rates are less
      volatile than headline ILS rates, (ii) core ILS rates comove less with oil prices than headline
      ILS rates, (iii) the core inflation expectations, as reflected in core ILS rates, typically evolve
      similarly as the core inflation projections by Eurosystem staff, and (iv) consistent with market
      commentary at the time, core ILS rates suggest that market participants expected core inflation
      to be substantially more persistent than headline inflation following the 2022 energy price spike.
    • To the best of our knowledge, we are the first to price core ILS rates and decompose them into
      market-based expectations for and risks around the core inflation outlook.
    • Our approach to inferring core ILS
      rates from headline ILS rates, realized headline and core inflation as well as survey expectations
      for headline and core inflation is also related to Ang et al.
    • Relative
      to their study, we separately measure core inflation expectations and risk premia, we provide
      core inflation expectations at a higher-frequency, and we provide evidence on the causal effects

      ECB Working Paper Series No 2908

      6

      of monetary policy shocks on core inflation expectations and risk premia.

    • Specifically, we decompose the synthetic core ILS rates
      into average expected core inflation over the lifetime of the swap contract and a core inflation
      risk premium that compensates investors for core inflation risk.
    • In
      our model below, this term is constant over time and relatively small, so we will simply refer
      to the core inflation risk premium as the difference between the core ILS rate and the average
      expected core inflation over the lifetime of the swap contract.
    • 3.2

      Core ILS rates

      To have a joint model for headline and core ILS rates, we need one further assumption on the
      dynamics of realized core inflation.

    • The assumption that core inflation is driven by the same set of factors as headline inflation
      should be relatively uncontroversial: since headline inflation is a weighted average of core and
      food and energy inflation, it should reflect any factors driving core inflation.
    • If there are factors
      driving food and energy inflation, which do not show up in core inflation, then those factors
      should still show up in headline inflation.
    • In step two, to be able to infer the factor
      loadings of core inflation, we would regress realized core inflation onto the estimated latent
      factors to identify the additional parameters in equation (12).
    • Before the fourth
      quarter of 2016, the SPF did not ask respondents for their core inflation expectations, so we
      are not able to use survey-based information about core inflation before then.
    • Before
      2016, the fitted core inflation series is somewhat above the realized one, potentially reflecting
      that the model has limited information about core inflation over this early period due to the
      lack of information about core inflation from surveys.
    • This could have been the
      case if one of the factors moved core inflation and energy and food inflation in exactly offsetting
      direction, so the overall impact on headline inflation was exactly zero.
    • During 2021, for example, there were

      ECB Working Paper Series No 2908

      25

      Figure 7: Decomposition of synthetic core ILS rates
      2y core ILS

      5y core ILS

      5
      4

      5
      ILS

      premia

      exp

      4

      ILS

      premia

      exp

      3

      3

      2

      2

      1

      1

      0

      0

      -1

      -1

      -2
      2017 2018 2019 2020 2021 2022 2023

      -2
      2017 2018 2019 2020 2021 2022 2023

      10y core ILS

      5y5y core ILS

      5
      4

      5
      ILS

      premia

      exp

      4

      ILS

      premia

      exp

      3

      3

      2

      2

      1

      1

      0

      0

      -1

      -1

      -2
      2017 2018 2019 2020 2021 2022 2023

      -2
      2017 2018 2019 2020 2021 2022 2023

      Note: Synthetic core ILS rates decomposed into genuine core inflation expectations and core inflation risk
      premia.

    • ECB Working Paper Series No 2908

      26

      Figure 8: Decomposition of ILS rates
      2y ILS

      5y ILS

      5
      4

      5
      ILS

      premia

      exp

      4

      3

      3

      2

      2

      1

      1

      0

      0

      -1

      -1

      -2
      2006

      2010

      2014

      2018

      2022

      -2
      2006

      ILS

      2010

      10y ILS

      2018

      2022

      5
      ILS

      premia

      exp

      4

      3

      3

      2

      2

      1

      1

      0

      0

      -1

      -1

      -2
      2006

      2014

      exp

      5y5y ILS

      5
      4

      premia

      2010

      2014

      2018

      2022

      -2
      2006

      ILS

      2010

      premia

      2014

      2018

      exp

      2022

      Note: ILS rates decomposed into genuine core inflation expectations and core inflation risk premia.

    • We find that the headline inflation risk premium
      indeed does responds more strongly than the core inflation risk premium.
    • The key
      assumption underlying our approach is that traded headline ILS rates span core inflation, which

      ECB Working Paper Series No 2908

      35

      should be reasonably uncontroversial as core inflation is a sub-component of headline inflation.

    • We fit the model to euro area headline ILS rates, realized headline and core inflation, and
      both headline and core inflation expectations reported in the SPF.
    • Decomposing our core ILS rates into genuine core inflation expectations and core
      inflation risk premia shows that shorter maturities mainly reflect core inflation expectations,
      while the core inflation risk premium matters relatively more for longer maturities.
    • Our results suggest that a monetary policy tightening surprise significantly lowers
      near-term core inflation expectations, although less so than it lowers headline inflation expectations.

Draft revised consolidated 3-year work plan for the Methodology Working Party (MWP)

Retrieved on: 
Wednesday, February 14, 2024

Industry level .................................................................................................. 13

Key Points: 
    • Industry level .................................................................................................. 13

      Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 2/14

      1.

    • A reflection paper
      (RP) on the clinical pharmacology package for oligonucleotides is a prioritised activity in the MWP work

      Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 3/14

      plan, and it is envisaged that something similar may be needed for other emerging treatment
      modalities (e.g., peptides).

    • Guideline work led by other working parties
      ?

      Revision of the guideline on the requirements for clinical documentation for orally inhaled
      products (CPMP/EWP/4151/00 Rev.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 4/14

      The planned concept papers (CPs) will formulate problem statements for potential workshops and
      subsequent guidance documents will be informed and enriched by the outcome of discussions of
      workshops to be held in 2024.

    • Guideline work led by other working parties and committees
      ?

      Revision of Guidance on the investigation of medicinal products in the term and preterm
      neonate (EMEA/536810/2008).

    • There is a need for
      Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 5/14

      new guidance in these areas to ensure these novel approaches meet the required evidentiary
      standards and facilitate their evaluation.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 6/14

      ?

      Revision of Guideline on clinical evaluation of diagnostic agents (CPMP/EWP/1119/98/Rev.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 7/14

      ?

      Provide appropriate support to the EU network for generic and hybrid medicines including
      product-specific requirements.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 8/14

      2.3.

    • ?

      Cross disciplinary work with Quality Working Party and other stakeholders on physiologically
      based biopharmaceutics modelling (PBBM).

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 9/14

      ?

      In order to support adequate evaluation of all methodology MWP will aim to facilitate an
      increase in presence and visibility in relevant committees of methodological expertise from
      across the EU network such as CHMP, PRAC, PDCO, CMD(h), ETF and CAT.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 10/14

      ?

      Product Specific Bioequivalence Guidelines (PSBGLs) (multiple) in liaison with CMD(h): for
      2024, azacitidine, budesonide (LALA GIT), trametinib, dabrafenib, paliperidone palmitate (3M
      depot) and melatonin have been prioritised as the next in series for drafting.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 11/14

      4.2.

    • ?

      Cross disciplinary work with Quality Working Party and other stakeholders on PBBM model
      assessment.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 12/14

      ?

      To deliver an improved access to raw data (e.g.

    • ?

      Propose regulatory research priorities for funders in across the activities of Methodology
      Working Party, including in the big data area.

    • ?

      Establish key communication points in national competent authorities and build a resource of
      key messages and communication materials on regulation and methodology.

    • The timing of workshops may need to be arranged according to the

      Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 13/14

      specific needs of the guidance ? either before the guidance is finalised to gather views and
      expertise; or once it is finalised for training purposes.

    • Revised consolidated 3-year work plan for the Methodology Working Party (MWP)
      EMA/CHMP/58124/2023

      Page 14/14

Global Wealth Forum Unveils 100 Model Leaders to Promote Wealth Creation Principles Across The World

Retrieved on: 
Monday, February 12, 2024

The Global Wealth Forum recognizes that the key to bridging the wealth gap lies in providing equal opportunities and empowering the young generation.

Key Points: 
  • The Global Wealth Forum recognizes that the key to bridging the wealth gap lies in providing equal opportunities and empowering the young generation.
  • The Model Leaders selected by the Global Wealth Forum embody a diverse range of backgrounds, industries, and experiences.
  • By showcasing the diverse pathways to wealth creation, the Global Wealth Forum hopes to encourage creativity, resilience, and adaptability among the younger generation.
  • Through the stories, experiences, and values of the Model Leaders, the Global Wealth Forum seeks to foster a generation of responsible, innovative, and socially conscious wealth creators.

ed2go & Model Teaching Announce Partnership to Offer an Extensive Menu of Online Professional Development & Continuing Education Courses to K-12 Teachers & Educators

Retrieved on: 
Tuesday, February 6, 2024

SUGAR LAND, Texas, Feb. 6, 2024 /PRNewswire-PRWeb/ -- With a partner network that is over 2,000 strong, ed2go is a world leader in online learning across dozens of in-demand professions and industries. Adding the Model Teaching course portfolio will help accelerate ed2go and Model Teaching's joint mission to provide cost-effective, online professional education options to teaching professionals and accelerate ed2go's leadership within the K-12 continuing education space.

Key Points: 
  • This partnership will integrate Model Teaching's professional development course menu with the industry-leading ed2go portfolio of white-label continuing education solutions, providing a wide range of high-quality personal and professional development course options through academic institutions, corporations, nonprofit organizations, and workforce development boards located in over 100 countries.
  • Adding the Model Teaching course portfolio will help accelerate ed2go and Model Teaching's joint mission to provide cost-effective, online professional education options to teaching professionals and accelerate ed2go's leadership within the K-12 continuing education space.
  • Online courses have become an attractive solution for educators to fulfill their professional development, certification, and licensing requirements.
  • Adding Model Teaching as an ed2go Partner will provide a much-needed option for teachers to fulfill these requirements.

Model N Launches Price Management to Help High-Tech Companies Streamline Pricing

Retrieved on: 
Tuesday, January 30, 2024

Fully integrated with Model N Deal Management, Price Management streamlines pricing updates to reduce the effort required to keep prices current and consistent – enabling tight pricing control and seamless market execution.

Key Points: 
  • Fully integrated with Model N Deal Management, Price Management streamlines pricing updates to reduce the effort required to keep prices current and consistent – enabling tight pricing control and seamless market execution.
  • With Model N’s Price Management, high-tech companies can effectively manage all aspects of pricing across the product lifecycle.
  • Price Management includes a robust pricing engine that provides real-time data to align with market realities—reducing revenue erosion and accelerating price setting.
  • Integrated with Model N’s Deal Management, Price Management distinguishes Model N as the leader in revenue cloud applications for high-tech companies.”
    For more information about Model N's Price Management, please visit www.modeln.com/products/price-management/ .

The effect of new housing supply in structural models: a forecasting performance evaluation

Retrieved on: 
Sunday, February 4, 2024
BET, Section 2, Model, XT, CIT, LTV, Forecasting, Total, Bank, RT, Elasticity, GDP, Website, University of Chicago Press, Process control block, Fiscal, Reproduction, University, WTP, Johns Hopkins University Press, E32, Faculty, Writing, KMR, Monetary economics, Household, Root mean square, YT, GFC, Language, VAR, A6, Motivation, Growth, PLT, Hartman–Grobman theorem, Research, House, Observation, Friction, Section 4, Classification, Macroeconomic model, BAA, AP, Kálmán, Odyssean Wicca, Parameter, Blue chip, A5, HPT, Mark Gertler, Learning, Smets, Inflation, ECB, Q2, Trade, CE, Hit, SPF, Review of Economic Dynamics, ZBW, Kolasa, LTM, R21, Patient, Prior, Shock, Movement, ZT, Australasian, M1, Lens, Great, Nobuhiro, European Central Bank, Estimator, Policy, LTI, COVID-19, Attention, HP, Feedback, Goethe University Frankfurt, International Journal of Forecasting, Federal Reserve, Federal Reserve Bank, Behavior, Health, Blue Chip Economic Indicators, Inverse, Zero lower bound, The Blue, Journal of Applied Econometrics, Economic forecasting, Matrix, Economy, Federal, R31, LTP, Chinese Blackjack, WTI, CES, Sim, Bit, Section 5, Capital market, Quantitative Economics, Credit, Motion, Central bank, Journal of Political Economy, Political economy, Taylor & Francis, Journal of Monetary Economics, Act, Binning, CPT, DPT, Point, MCMC, RealTime, Literature, Metropolis–Hastings algorithm, ZLB, TFP, Research Papers in Economics, Del Negro, GBT, Communication, Kalman filter, Markov, Cycle, Business cycle, Eurozone, DFF, PDF, Filter, Medical classification, American Economic Journal, Demand shock, Comparison, Employment, KTEH, Cobb–Douglas production function, Nonprofit organization, Sampler, PTW, Par, Liquidity trap, Paper, Nominal interest rate, QT, Exercise, Monetary policy, RTD, Interest rate, A7, University of Cambridge, Control, Statistics, Posterior, Pressure, American Economic Review, E37, Financial intermediary, Social science, Basel II, Delphic, Depreciation, European Economic Review, HPD, Ai, Calendar, E17, Government, Journal of Econometrics, HTM, Freedom, LTE, Probability, Face, Calibration, Oxford University Press, New Keynesian economics, Sun, HH, Me, Uncertainty, FPI, Production, Dynamics, Handbook, Real estate

Key Points: 

    Americans Buy Nearly 1.2 Million Electric Vehicles to Hit Record in 2023, According to Latest Kelley Blue Book Data

    Retrieved on: 
    Tuesday, January 16, 2024

    ATLANTA, Jan. 16, 2024 /PRNewswire/ -- As the shift toward an electrified future continues, a record-breaking nearly 1.2 million U.S. vehicle buyers chose to go electric last year, according to the latest data from Kelley Blue Book, a Cox Automotive company.

    Key Points: 
    • ATLANTA, Jan. 16, 2024 /PRNewswire/ -- As the shift toward an electrified future continues, a record-breaking nearly 1.2 million U.S. vehicle buyers chose to go electric last year, according to the latest data from Kelley Blue Book, a Cox Automotive company.
    • Specifically, in Q4 2023, EV sales hit a record for both volume and market share, with sales reaching 52% higher than in the fourth quarter of 2022.
    • Americans bought 317,168 EVs between October and the end of December 2023, representing 8.1% of all new cars sold.
    • Tesla continues to dominate the EV market; 55% of the electric vehicles Americans purchased in 2023 were Tesla products.