DSM-IV codes

Migraine sufferers in England may soon be able to access preventative drug – here’s how atogepant works

Retrieved on: 
Tuesday, April 23, 2024

Atogepant (brand name: Aquipta) was recently recommended by the National Institute for Health and Care Excellence (Nice) to prevent episodic and chronic migraine attacks.

Key Points: 
  • Atogepant (brand name: Aquipta) was recently recommended by the National Institute for Health and Care Excellence (Nice) to prevent episodic and chronic migraine attacks.
  • The drug would be recommended to people who have at least four migraine days a month or where at least three previous preventative treatments have failed.
  • Migraine is a complex neurological condition that affects about 10 million people in the UK.
  • It’s characterised by recurrent, severe headaches that can be made worse by physical activity and are often debilitating.
  • However, it’s only suited to patients who suffer from episodic migraines – whereas atogepant can be used by people who have both chronic and episodic migraines.

Consistently effective


Three clinical trials have shown atogepant to be safe and effective for people with episodic or chronic migraines.

  • The Advance trial evaluated how safe and effective different doses of atogepant were compared with a placebo in preventing episodic migraine.
  • The 60mg once-daily tablet was found to be well tolerated and effective, leading to nearly seven fewer migraine days per month.
  • A third trial, the 302-LTS trial, followed participants who suffered from episodic migraine for over a year, finding that atogepant was consistently effective for reducing migraine attacks.
  • Atogenpant was consistently shown to be safe across all studies, including the one that lasted for a year.


Anna Andreou receives funding from the Medical Research Foundation and Brain Research UK. She also received research funding from eNeura, AbbVie and Pfizer. She is affiliated with the International Headache Society, being elected as a Trustee of the Board. She is Chair of the Headache special interest group of the British Pain Society.

What if flat feet were…normal? Debunking a myth about injuries

Retrieved on: 
Tuesday, April 23, 2024

Specifically, having flat feet was believed to predispose individuals to future pain and other musculoskeletal problems (i.e.

Key Points: 
  • Specifically, having flat feet was believed to predispose individuals to future pain and other musculoskeletal problems (i.e.
  • Flat feet were believed to be a kind of time bomb.
  • We demonstrate that the theory that having flat feet inevitably leads to pain or other musculoskeletal problems, is unfounded.

Where does this theory come from?

  • This theory became central to the educational programs of health professionals.
  • In fact, science has never validated the theory: it has remained at the hypothesis stage.
  • Nevertheless, over the years up until the present, many health professionals have continued to support the theory that flat feet pose a major risk for developing musculoskeletal disorders.

Do flat feet cause musculoskeletal injuries?

  • Furthermore, a systematic review and a meta-analysis concluded that runners with flat feet are no more at risk of injury than those with regular feet.
  • These analyses call into question the idea that people with flat feet have a substantial risk of developing musculoskeletal disorders.
  • Unfortunately, this frequently results in people having unnecessary interventions, such as using orthopaedic shoes or custom-made foot orthoses for asymptomatic flat feet.

Setting the record straight

  • Based on current scientific knowledge, assessing whether a person has flat feet to determine their risk of injury is ineffective and counterproductive.
  • While it is possible for a person with flat feet to develop a musculoskeletal injury, this does not necessarily mean that flat feet caused the injury.
  • It is quite possible for two variables to be present at the same time without there being a causal link.
  • A cause-and-effect relationship implies that a change in one variable (the cause) leads to a change in another variable (the effect).

Reducing overdiagnosis in health care

  • Reducing overdiagnosis in health care has become crucial.
  • Since overdiagnosis often leads to overtreatment, avoiding unnecessary treatments will help to alleviate patients’ concerns about their flat feet.
  • It’s time to change our perspective and our approach to the significance of flat feet and to recognize their natural diversity in the context of overall foot health.


Gabriel Moisan is a member of the Ordre des Podiatres du Québec (College of Podiatrists Québec). He has received funding from the Natural Sciences and Engineering Research Council of Canada (NSERC), the War Amps of Canada and the Réseau provincial de recherche en adaptation-réadaptation (REPAR).

Good news: midlife health is about more than a waist measurement. Here’s why

Retrieved on: 
Friday, April 19, 2024

During the appointment they measure your waist.

Key Points: 
  • During the appointment they measure your waist.
  • GPs and health professionals commonly measure waist circumference as a vital sign for health.
  • Men are at greatly increased risk of health issues if their waist circumference is greater than 102 centimetres.
  • More than two-thirds of Australian adults have waist measurements that put them at an increased risk of disease.

How much is too much?

  • A ratio of 0.6 or more places a person at the highest risk of disease.
  • This can kick off a discussion about their risk of chronic diseases and how they might address this.
  • For women, hormone levels begin changing in mid-life and this also stimulates increased fat levels particularly around the abdomen.
  • Finally, your family history and genetics can make you predisposed to gaining more abdominal fat.

Why the waist?

  • Visceral fat surrounds and infiltrates major organs such as the liver, pancreas and intestines, releasing a variety of chemicals (hormones, inflammatory signals, and fatty acids).
  • These affect inflammation, lipid metabolism, cholesterol levels and insulin resistance, contributing to the development of chronic illnesses.
  • In addition to the direct effects of hormone changes, declining levels of oestrogen change brain function, mood and motivation.
  • These psychological alterations can result in reduced physical activity and increased eating – often of comfort foods high in sugar and fat.
  • And importantly, the waist circumference (and ratio to height) is just one measure of human health.

Muscle matters

  • On current evidence, it is equally or more important for health and longevity to have higher muscle mass and better cardiorespiratory (aerobic) fitness than waist circumference within the healthy range.
  • So, if a person does have an excessive waist circumference, but they are also sedentary and have less muscle mass and aerobic fitness, then the recommendation would be to focus on an appropriate exercise program.
  • Conversely, a person with low visceral fat levels is not necessarily fit and healthy and may have quite poor aerobic fitness, muscle mass, and strength.

Getting moving is important advice

  • Exercise can counter a lot of the negative behavioural and physiological changes that are occurring during midlife including for people going through menopause.
  • And regular exercise reduces the tendency to use food and drink to help manage what can be a quite difficult time in life.
  • Measuring your waist circumference and monitoring your weight remains important.


Rob Newton receives funding from National Health and Medical Research Council, the Medical Research Future Fund, Cancer Council Western Australia, Spinal Cord Injuries Australia and the World Cancer Research Fund. Rob Newton is a board member of The Healthy Male.

Getting a good night’s rest is vital for neurodiverse children – pediatric sleep experts explain why

Retrieved on: 
Friday, April 19, 2024

If you’re a parent with kids at home, it often leaves you and your children on edge.

Key Points: 
  • If you’re a parent with kids at home, it often leaves you and your children on edge.
  • Children with neurodiverse conditions, such as autism and attention-deficit/hyperactivity disorder, or ADHD, are even more susceptible to the effects of poor sleep, given their emotional reactivity and impulsivity..
  • Struggles with sleep have been linked to increased aggression, irritability, inattention and hyperactivity in children with autism spectrum disorder.

The science behind sleep difficulties

  • There are multiple reasons why neurodiverse children don’t sleep well, including medical conditions, biological causes and behavioral and environmental factors.
  • Medical conditions, such as obstructive sleep apnea or epilepsy, can affect a child’s sleep.
  • Medications that are used to treat medical conditions, such as antidepressants for mood disorders or stimulants for ADHD, can further disrupt sleep.

Treating sleep problems


All of these factors can be addressed and treated. A thorough evaluation by the child’s health care provider may reveal a medical cause, or medication, that is interfering with sleep. Behavioral approaches can make a big difference in improving sleep. These might include:
Changes to daytime habits, including getting lots of morning light and physical activity.
Shifts in evening habits, such as removing all screens (TV, computers, phones, etc.) and establishing calming bedtime routines.
Modifications to how a parent interacts with their child for those families who would like a child to fall asleep and stay asleep independently.

  • It’s important to note that not all families want their children to sleep on their own.
  • Because there are so many factors that can cause disrupted sleep, addressing sleep problems cannot be a one-size-fits-all approach and should be done in partnership with parents.
  • Our team has developed a family-centered approach to address sleep problems in neurodiverse children.

The ups and downs of melatonin

  • While behavioral approaches are recommended as a first-line treatment, melatonin can be helpful in jump-starting a behavioral routine.
  • Overdoses can result from children eating a bunch of gummies, or parents not understanding how much melatonin is safe to give.
  • To help parents sift through all the resources and articles on melatonin on the internet and social media, one of us created a video and wrote several blogs on melatonin safety.
  • These include topics like whether children can become dependent on melatonin supplements over time, whether taking melatonin will delay puberty, whether children might experience side effects from taking melatonin and more.

Promoting healthier sleep


Here are some general tips for helping your child sleep better, regardless of whether they are neurodiverse:
Choose a consistent bedtime and wake time. This consistency will help children’s own natural melatonin kick in.
Make sure bedtime isn’t too early. For example, an 8 p.m. bedtime is too early for most 10-year-olds. Neurodiverse children may struggle to sleep and will become more anxious, which makes going to sleep even harder.
Help your child get natural sunlight in the morning. Morning sunlight sets our brain’s internal clock so that we can fall asleep more easily at bedtime.
Ensure your child is getting physical activity during the day.
Minimize naps longer than one hour, or after 4 p.m. for school-age children. Naps can interfere with going to sleep at night.
Avoid caffeine, including many types of soda, tea and chocolate.
Turn off all screens and smartphones at least 30 minutes before bedtime.
In the evening leading up to bedtime, turn down all lights in the house. Consider using red night lights, if possible. Set any devices to night mode in the evening to limit exposure to blue light.
Create wind-down time in place of screens. Have your child identify an activity they enjoy that is calming and soothing, such as reading a book, coloring or listening to music. If a bath is stimulating, move it to earlier in the evening, such as after dinner.
Help your child learn to fall asleep without needing you or their devices to be there with them. That way, they will settle down on their own at bedtime. And when they wake up throughout the night, since we all wake up in the night, they will be able to go right back to sleep without becoming fully awake.
For more tips, see Autism Speaks for free downloads of brochures and visual aids.

  • She also receives funding from the American Academy of Sleep Medicine.
  • She has received funding from the American Academy of Sleep Medicine and Autism Speaks for research on sleep in children with ASD.

Climate change makes life harder: in South Africa it’s likely to bring heatwaves, water stress and gender-based violence

Retrieved on: 
Thursday, April 18, 2024

Human-induced climate change made the severe 2015–2017 drought three to six times more likely.

Key Points: 
  • Human-induced climate change made the severe 2015–2017 drought three to six times more likely.
  • Our new report on Climate Change Impacts in South Africa has found that as Earth warms, people living in South Africa will face reduced incomes, less food and water security and a higher cost of living.
  • Our findings, based on a synthesis and review of existing research on climate change, are that climate change and socioeconomic risks threaten to bring about a huge change to this status.
  • Combating the impacts of climate change in South Africa requires adaptive measures, such as changing the way we farm, coordination by the government and international commitment to reduce emissions.

Heatwaves

  • Farm workers will be exposed to more extreme temperatures working outside and others will suffer from heat stress in their living and working environment.
  • Here's how

    Extreme weather threatens the plants and animals that attract tourism, and directly damages infrastructure at nature reserves, adventure destinations and parks.

  • Rising temperatures are projected to reduce visitor numbers to South Africa’s national parks by 4% by 2050, affecting the Kruger National Park most.

An agricultural crisis

  • Smallholder farms are often located in areas with less fertile soils or limited infrastructure, leaving these farmers more vulnerable to climate change.
  • Arable land suitable for growing crops is concentrated in just 12% of South Africa’s land area.
  • Therefore, any extreme event that reduces production – such as drought – can be expected to reduce job security and income for farming households and agricultural workers.

Water

  • Drought and floods damage transport links, public buildings, and water and energy infrastructure, and challenge the provision of basic services.
  • During the water crisis that followed the 2015–2017 drought, for example, reservoirs serving 3.7 million people around Cape Town dropped to 20% of capacity, leading the government to impose water restrictions.

An increase in gender-based violence

  • These gender inequalities include a high incidence of gender-based violence and a higher likelihood of poverty among women.
  • Research in other parts of the world has also linked rising temperatures with an increase in gender-based violence.

Solutions


Much of the country’s economic future hinges on the speed with which investments in renewable energy can replace coal and provide affordable and reliable electricity. Slowing down climate change will take a huge global effort and progress has been limited. The only alternative is to be prepared and adapt to the projected changes.
Peter Johnston receives funding from United Nations, NORCE, NRF

Many suicides are related to gambling. How can we tackle this problem?

Retrieved on: 
Thursday, April 18, 2024

Whether you’re watching TV, attending a footy game, or eating a meal at your local pub, gambling is hard to escape. Although the rise of gambling is not unique to Australia, it has become normalised as a part of Australian culture. While for some, gambling might be a source of entertainment, for others, it can lead to significant harms.Gambling and mental illnessIn many cases, harms associated with gambling lead to poor mental health.

Key Points: 


Whether you’re watching TV, attending a footy game, or eating a meal at your local pub, gambling is hard to escape. Although the rise of gambling is not unique to Australia, it has become normalised as a part of Australian culture. While for some, gambling might be a source of entertainment, for others, it can lead to significant harms.

Gambling and mental illness

  • In many cases, harms associated with gambling lead to poor mental health.
  • But people experiencing mental illness are also at greater risk of experiencing gambling problems.
  • A person might not have a diagnosable gambling disorder, however they still may face problems in their life as a result of gambling.

Gambling and suicide

  • Research from different countries has shown that among people receiving treatment for problem gambling, between 22% and 81% have thought about suicide, and 7% to 30% have made an attempt.
  • Some 44% of Australian veterans experiencing gambling problems have thought about suicide, while almost 20% have made a suicide plan or attempt.
  • Gambling-related suicides were more likely to affect males (83%) compared to total suicide deaths in Victoria over the same period (75%).
  • This is because, unlike for drugs and alcohol, at present there’s no systematic way gambling is captured as a contributing factor in suicide deaths.

Gambling is inherently risky

  • Evidence shows pokies alone are responsible for more than half of all gambling problems in Australia.
  • Casino table games are equally risky, but in the general population they contribute much less to problem gambling because fewer people play them.

What can we do?

  • She suggested health professionals could make it part of their routine practice to ask simple questions like “in the past 12 months, have you ever felt that you had a problem with gambling?”.
  • Or, “has anyone commented that you might have a problem with gambling?”.
  • In June 2023, a cross-party committee presented a report with 31 recommendations to reduce harms from online gambling in Australia.
  • Read more:
    Celebrities, influencers, loopholes: online gambling advertising faces an uncertain future in Australia

Advice for people who gamble

  • For people who do choose to gamble, it’s important to be aware of the risks.
  • If you choose to gamble, set limits on the amount of money you’re willing to loose, or the amount of time you will spend gambling.


gamble no more than 2% of your take-home pay
gamble no more than once a week
take part in no more than two different types of gambling.
If you notice you’re thinking about gambling more and more, or that it’s causing problems in any part of your life, seeking help early is key. Speak to your GP about how you can get some extra support, or visit Gambling Help Online. If this article has raised issues for you, or if you’re concerned about someone you know, call Lifeline on 13 11 14.
Anastasia Hronis does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Orphan designation: (6aR,10aR)-3-(1',1'-dimethylheptyl)-delta-8-tetrahydrocannabinol-9-carboxylic acid- Treatment of cystic fibrosis, 14/10/2016 Withdrawn

Retrieved on: 
Thursday, April 18, 2024

Orphan designation: (6aR,10aR)-3-(1',1'-dimethylheptyl)-delta-8-tetrahydrocannabinol-9-carboxylic acid- Treatment of cystic fibrosis, 14/10/2016 Withdrawn

Key Points: 


Orphan designation: (6aR,10aR)-3-(1',1'-dimethylheptyl)-delta-8-tetrahydrocannabinol-9-carboxylic acid- Treatment of cystic fibrosis, 14/10/2016 Withdrawn

Orphan designation: Sodium (4-{(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-yl-prop1ynyl)phenyl]allyloxy}-2-methylphenoxy)acetate Treatment of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency, 21/08/2020 Withdrawn

Retrieved on: 
Thursday, April 18, 2024

Orphan designation: Sodium (4-{(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-yl-prop1ynyl)phenyl]allyloxy}-2-methylphenoxy)acetate Treatment of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency, 21/08/2020 Withdrawn

Key Points: 


Orphan designation: Sodium (4-{(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-yl-prop1ynyl)phenyl]allyloxy}-2-methylphenoxy)acetate Treatment of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency, 21/08/2020 Withdrawn

Orphan designation: Sodium (4-{(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-yl-prop1ynyl)phenyl]allyloxy}-2-methylphenoxy)acetate Treatment of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, 21/08/2020 Withdrawn

Retrieved on: 
Thursday, April 18, 2024

Orphan designation: Sodium (4-{(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-yl-prop1ynyl)phenyl]allyloxy}-2-methylphenoxy)acetate Treatment of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, 21/08/2020 Withdrawn

Key Points: 


Orphan designation: Sodium (4-{(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-yl-prop1ynyl)phenyl]allyloxy}-2-methylphenoxy)acetate Treatment of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, 21/08/2020 Withdrawn

Orphan designation: 6'-(R)-methyl-5-O-(5-amino-5,6-dideoxy-α-L-talofuranosyl)-paromamine sulfate Treatment of mucopolysaccharidosis type I, 22/09/2016 Positive

Retrieved on: 
Thursday, April 18, 2024

Orphan designation: 6'-(R)-methyl-5-O-(5-amino-5,6-dideoxy-α-L-talofuranosyl)-paromamine sulfate Treatment of mucopolysaccharidosis type I, 22/09/2016 Positive

Key Points: 


Orphan designation: 6'-(R)-methyl-5-O-(5-amino-5,6-dideoxy-α-L-talofuranosyl)-paromamine sulfate Treatment of mucopolysaccharidosis type I, 22/09/2016 Positive