Mitochondrion

• “The NAYA leadership team brings an agile entrepreneurial platform, broad development and commercialization experience, and access to public capital, which will unlock the potential of our promising AAV gene therapy platform for mitochondrial genetic diseases.
• The program has received over $6 million in grant funding to date and qualifies for Regenerative Medicine Advanced Therapy (RMAT) designation and multiple priority FDA review vouchers.
• The combination of multiple orphan indications, multiple routes of administration, and multiple AAV serotypes applicable supports a broad gene therapy platform for mitochondrial orphan diseases.
• The Florida Biotechnologies Transaction is contingent on the closing of the INVO Merger and sufficient financing to further develop the gene therapy programs from Florida Biotechnologies.

• This method, utilizing extracellular vesicles from mesenchymal stromal cells (imEVs), marks a significant advancement in mitochondrial medicine.
• Karl-Henrik Grinnemo and Sergey Rodin of Uppsala University, vital contributors to this research, described the study as a "milestone in mitochondrial science."
• "The partnership with Elliott Mitochondrial Center and the Sallie Astor Burdine Breast Foundation has been instrumental in this discovery, reflecting our collective commitment to pioneering medical solutions," he stated.
• This collaborative effort represents a major addition to MitoSense Inc.'s achievements, highlighting the company's crucial role in advancing medical science and enhancing patient care.

• This strategic move reinforces Pearsanta’s dedication to enhancing patient outcomes through early disease detection and the power of precision diagnostics.
• The platform includes a rich biomarker portfolio addressing a wide range of high-priority health concerns beyond oncology, extending into areas of substantial medical need.
• Highlights from the asset portfolio include:
  The Mitomic Endometriosis Test (MET™) is in development as a blood-based assay for diagnosis of endometriosis.
• The overarching goal is to enhance clinical outcomes by offering non-invasive or minimally invasive testing at the early stages of disease progression.

• Crash diets have been around for years, but have stayed popular more recently thanks to influencers and social media.
• Typically, these diets involve drastically reducing calorie intake to 800-1,200 calories a day for a few weeks at a time.
• Proponents of these diets claim it can lead to rapid weight loss, which may explain why they have such a significant appeal.
• But while these diets may lead to short-term weight loss success in some people, they can have the long-term consequence of damaging your metabolism.

Crash diets and metabolism

• Your metabolism is affected by many things – including diet, exercise and your hormones.
• Crash diets affect all these components.
• In the short-term, crash diets can lead to feelings of tiredness, which makes doing any activity (let alone a workout) challenging.

• In the long term, crash diets can change the hormone makeup of our bodies.
• And over an extended period of time, typically months, high cortisol levels can cause our body to store more fat.
• Crash diets can also reduce levels of the hormone T3, which is produced by the thyroid gland.

Gradual dieting

• If you’re trying to lose weight, the best strategy to use is following a long-term, gradual weight loss diet.
• Gradual diets have been shown to be more sustainable and have a less negative impact on your metabolic rate compared with crash diets.
• Gradual diets can also help maintain energy levels enough to exercise, which can help you lose weight.
• This creates a greater capacity for burning calories even after we finish dieting.

Christopher Gaffney receives research funding from Omega EFA Limited.