National Health

Lisata Therapeutics Announces Enhancements to Ongoing Phase 2b ASCEND Trial of LSTA1

Retrieved on: 
Wednesday, May 24, 2023
Pancreatic cancer, University, Cohort, Research, SOC, Cohort study, National Health and Medical Research Council, CTC, National Health, ASCEND, Patient, Cancer, Mortality, Therapy, Medical Research Council, Pharmaceutical industry

BASKING RIDGE, N.J., May 24, 2023 (GLOBE NEWSWIRE) -- Lisata Therapeutics, Inc. (Nasdaq: LSTA) (“Lisata” or the “Company”), a clinical-stage pharmaceutical company developing innovative therapies for the treatment of advanced solid tumors and other serious diseases, today announced protocol changes to the ongoing ASCEND trial, a Phase 2b trial evaluating LSTA1, Lisata’s lead investigational drug, in combination with standard-of-care (“SOC”) gemcitabine/nab-paclitaxel in patients with first-line, metastatic pancreatic ductal adenocarcinoma (“mPDAC”). The objective of the original ASCEND trial was to confirm, in a rigorous, controlled, double-blind study, the positive results of the Phase 1b/2a open label study evaluating LSTA1 in mPDAC patients receiving one dose of LSTA1 plus SOC. The amended protocol retains this objective while adding the goals of optimizing the dose of LSTA1 in this indication and establishing effect size for a possible Phase 3 study. The protocol amendment includes an additional cohort (Cohort B) to assess whether a second dose solely of LSTA1, administered 4 hours after the original dose of LSTA1 plus SOC, will further improve efficacy and patient outcomes.

Key Points: 
  • The objective of the original ASCEND trial was to confirm, in a rigorous, controlled, double-blind study, the positive results of the Phase 1b/2a open label study evaluating LSTA1 in mPDAC patients receiving one dose of LSTA1 plus SOC.
  • The amended protocol retains this objective while adding the goals of optimizing the dose of LSTA1 in this indication and establishing effect size for a possible Phase 3 study.
  • The trial is fully funded by Lisata through an unrestricted research support agreement.
  • “We are excited to announce the enhancements to the ASCEND trial design, including the addition of a second cohort for the evaluation of a second dose of LSTA1 in patients with mPDAC.

“Cigarettes belong in museums,” says Philip Morris International CEO in speech in London

Retrieved on: 
Tuesday, May 23, 2023
Other Consumer, Other Retail, Consumer, Retail, Tobacco, Smoke, Smoker, Intellectual property, Nutrition, Information, Prevalence, Nicotine, Life, Marketing, Public, IQOS, Philip Morris International, ZYN, COVID-19, Policy, Olczak, Woman, Research, Minor, Privacy, Sale, Government, Thought, Organization, National Health, Annual report, Risk, Lip, Form, Toxicology, Mortality, FDA, Smoking, Glass, NYSE, Regulation of food and dietary supplements by the U.S. Food and Drug Administration, Food, World Health Organization, PMI, Risk management, EU

Jacek Olczak, Chief Executive Officer of Philip Morris International Inc. (PMI) (NYSE: PM), today delivered remarks at the UnHerd Club in London, calling on governments globally to accelerate the end of cigarettes.

Key Points: 
  • Jacek Olczak, Chief Executive Officer of Philip Morris International Inc. (PMI) (NYSE: PM), today delivered remarks at the UnHerd Club in London, calling on governments globally to accelerate the end of cigarettes.
  • The persistence of high smoking rates globally is evidence that the current approach to ending cigarette use is not working quickly enough.
  • Let there be no mistake: People who have never used tobacco or nicotine, especially minors, should not use these products.
  • Here’s the curious thing: I’m moving Philip Morris International out of cigarettes, but the faster I go, the more people shout at me.

CDC Data Shows More US Children are Overexposed to Fluoride Than Ever Before

Retrieved on: 
Monday, May 8, 2023
Yang, Tissue, National Health and Nutrition Examination Survey, Ecotoxicology, Water, Prevalence, The United People of Canada, Government, Cochrane (organisation), CDC, Uric acid, National Health, Menstruation, Blood, Kidney, NHANES, Biophysical environment, Infant, Fluorosis, Sleep, Neurotoxicity, Korea Disease Control and Prevention Agency, Dental, Birth control, Dentistry, Phosphorus

NORTH SUTTON, N.H., May 8, 2023 /PRNewswire/ -- Government data shows that tens-of-millions of U.S. residents have visible signs of overexposure to fluoride.

Key Points: 
  • NORTH SUTTON, N.H., May 8, 2023 /PRNewswire/ -- Government data shows that tens-of-millions of U.S. residents have visible signs of overexposure to fluoride.
  • The US Centers For Disease Control's (CDC) National Health and Nutrition Examination Survey (NHANES) has consistently found skyrocketing rates of dental fluorosis, reports the Fluoride Action Network .
  • The CDC reported that 41% of adolescents (12 to 15) had dental fluorosis in 2004.
  • At the time, this was an increase of over 400% from the rates found 60 years prior.

Statement by the Prime Minister of Canada on the passing of the Honourable Marc Lalonde

Retrieved on: 
Monday, May 8, 2023
Manny Villafaña, Justice, Friends, International, Politics, International court, Woman, Health policy, Parliament, National Health, Government of Canada, Health, Death, World Health Organization, Lalonde report

OTTAWA, ON‪, May 7, 2023 /CNW/ - The Prime Minister, Justin Trudeau, today issued the following statement on the death of the Honourable Marc Lalonde:

Key Points: 
  • OTTAWA, ON‪, May 7, 2023 /CNW/ - The Prime Minister, Justin Trudeau, today issued the following statement on the death of the Honourable Marc Lalonde:
    "Today, it is with great sadness that I learned of the passing of the Honourable Marc Lalonde, a giant of Canadian politics.
  • "Marc was so many things, but above all, he was a proud Canadian – and he exemplified it.
  • He was a good friend of my father's, and it was clear he had a lot of respect for Marc.
  • He worked tirelessly to better the lives of Canadians, and his passing is an enormous loss for our country.

Generic Drugs Global Market Report 2023: Growing Demand for Low-Cost Drugs Bolster Sector - ResearchAndMarkets.com

Retrieved on: 
Wednesday, May 3, 2023
Health, Pharmaceutical, Molecule, COPD, Urbanization, Patent, Insurance, Asthma, Drug delivery, Prevalence, Diabetes, Marketing, Arthritis, Fingolimod, Cetuximab, Ageing, Cancer, Head, Research, Tobacco, Multiple sclerosis, Bristol Myers Squibb, USD, Competition, Hypertension, Market, Malignancy, Death, US, Chronic Respiratory Disease, National Health, Chronic condition, Patient, Application, Developed country, National Health Interview Survey, Plasma protein binding, Form, Conditional sentence, Growth, WHO, FDA, Notifiable disease, Safety, Generic drug, Pharmaceutical industry

The Generic Drugs market is expected to continue growing in the coming years, driven by factors such as the increasing prevalence of chronic diseases, expiration of patent drugs, growing demand for low-cost drugs, and easy accessibility and supportive governments for allowing generic drugs in the market.

Key Points: 
  • The Generic Drugs market is expected to continue growing in the coming years, driven by factors such as the increasing prevalence of chronic diseases, expiration of patent drugs, growing demand for low-cost drugs, and easy accessibility and supportive governments for allowing generic drugs in the market.
  • Advancements in generic drugs have also contributed to the growth of the Generic Drugs market.
  • One of the biggest challenges the global generic drugs market is facing is ensuring the quality of generic drugs is the same as branded drugs.
  • This has led to increased demand for generic drugs in these regions, which has, in turn, contributed to the growth of the global generic drugs market.

Studies on Aging and Late-Life Functioning Given Policy Impact Award

Retrieved on: 
Wednesday, May 3, 2023
National Institute on Aging, University, Johns Hopkins Bloomberg School of Public Health, Public opinion, Disability, NSOC, Nationalism studies, Policy, NIA, University of Frankfurt Institute for Social Research, Dementia, Ageing, Quality of life, Data collection, ISR, Research, Social Research (journal), Population Studies Center at the University of Michigan, Doctor of Philosophy, National Institutes of Health, Bangladesh Technical Education Board, American Association for Public Opinion Research, Public health, National Health, Johns Hopkins University, Faculty, Growth, Health, AAPOR, Social, Death, Family, NIH, Alzheimer's disease, Caregiver, Residential care, Nursing, Westat

ROCKVILLE, Md., May 3, 2023 /PRNewswire/ -- The National Health and Aging Trends Study (NHATS) and National Study of Caregiving (NSOC) have been awarded the 2023 Policy Impact Award by the American Association for Public Opinion Research (AAPOR). According to AAPOR, the award recognizes "outstanding research that has had a clear impact on improving policy decisions, practice and discourse, either in the public or private sectors."

Key Points: 
  • ROCKVILLE, Md., May 3, 2023 /PRNewswire/ -- The National Health and Aging Trends Study (NHATS) and National Study of Caregiving (NSOC) have been awarded the 2023 Policy Impact Award by the American Association for Public Opinion Research (AAPOR).
  • According to AAPOR, the award recognizes "outstanding research that has had a clear impact on improving policy decisions, practice and discourse, either in the public or private sectors."
  • Funding for NHATS and NSOC is provided by the National Institute on Aging (NIA), National Institutes of Health (NIH).
  • NHATS and NSOC have grown to become a catalyst for policy- and practice-relevant analyses of aging, disability, and care.

Nobel laureate Brian Schmidt's big ideas for how Australia funds and uses research

Retrieved on: 
Tuesday, April 25, 2023
Workforce, Review, Private sector, National university, GPS, Industry, International, Democracy, The Lucky Country, Education, Vocational education, Culture, Solution, University, OECD, Research, Wi-Fi, Goal, Government, Translation, Accord, Australian Research Council, National Health, GDP, Investment, National Health and Medical Research Council, Nobel, Physics, Australian National University, Federation, Ecosystem, System, Health, Medical Research Council, Tutoring, Renewable energy, Nursing, Pharmaceutical industry, Security (finance)

The federal government is calling for ideas to “reshape and reimagine higher education, and set it up for the next decade and beyond”.

Key Points: 
  • The federal government is calling for ideas to “reshape and reimagine higher education, and set it up for the next decade and beyond”.
  • In my personal submission to the accord process, I outline three big ideas to help reset higher education to deliver the system Australians need and deserve.
  • In this piece I want to focus on my other two big ideas – improving the way we fund and then translate research.

Australia’s research ecosystem

    • Australia’s research ecosystem has become highly reliant on funding via cross-subsidies from international student fees.
    • Instead, universities now spend more on research (using international student fees) than the government.
    • Research funding is also not fully integrated with workforce and major equipment needs, and this all leads to shortfalls in key areas of national research need.

We need to identify and properly fund sovereign research

    • Sovereign research capability is about Australia being able to fund and undertake the research it deems vital to its national interests.
    • We must identify the core set of sovereign research capabilities necessary for the future security and prosperity of the Australian people.
    • A large fraction of the sovereign curiosity research money should be competitively allocated via existing bodies, the Australian Research Council and National Health and Medical Research Council grant system.

We need to make it easier to translate research

    • In addition to fully funding sovereign research capabilities, we must also rethink how we fund research translation for the public good.
    • This is the process whereby we move research from labs or journals out into the real world.
    • When we fund applied research, we need to be strongly focused on outcomes.
    • This includes the government directing funding for specific missions in areas of national need.

Blue-sky thinking

    • This is the research universities do that leads to new products, jobs and industries never envisaged when the research cycle begins.
    • These are hard to measure, and emerge with a considerable lag, but our best estimates are that they are large.
    • Government has a special role in funding this activity, as firms cannot typically capture the benefits of this work.
    • Alternatively, new types of future higher education institutions could have research dropped from their mission entirely.

Making our own luck

    • The government’s accord process gives us the chance to make sure our universities can continue to deliver on this promise for our future generations.
    • If we fail to value and fund university research in the way that we need, and should, the so-called Lucky Country might just run out of luck.

Educational Video Game Produces Dramatic Cuts in Bullying

Retrieved on: 
Wednesday, March 29, 2023
Psychology, School, Cornell University, State University of New York, Student, Senior, Anxiety, NHPA, LifeSkills Center of Middletown, State university system, State University of New York at Purchase, IPad, Anger, George Mason University, Psychological abuse, Attention, Educational technology, Bullying, National Health, Assertiveness, LST, Knowledge, Weill Cornell Medicine, Galaxia, Nursing, Management, Adolescence

The new video game, LST Galaxia, is designed to be interactive, engaging, and visually appealing to capture students' attention and interest.

Key Points: 
  • The new video game, LST Galaxia, is designed to be interactive, engaging, and visually appealing to capture students' attention and interest.
  • The current study is the first to test an educational video game adaptation of LST.
  • This study also demonstrates the effectiveness of an enhanced classroom version of the LST program when combined with an interactive educational video game.
  • Students in the intervention group received the LST prevention program along with added bullying prevention content and played the video game.

BioCina Awarded Grant to Develop Enabling Technologies for Manufacturing Precision mRNA Vaccines

Retrieved on: 
Tuesday, March 28, 2023
Vaccine, GMP, DNA, MRFF, University, Cis, Therapy, U.S. federal government response to the COVID-19 pandemic, Fermentation, Australian government debt, Research, RNA, Messenger, Microfluidics, Federation, AUD, National Health, CDMO, National Health and Medical Research Council, SAN, South Australian Government Gazette, NHMRC, LNP, Medical Research Future Fund, Medical Research Council, Pharmaceutical industry

SAN DIEGO and ADELAIDE, Australia, March 28, 2023 /PRNewswire/ -- BioCina , a leading contract development and manufacturing organization (CDMO), has been awarded a $5 million AUD grant under the Federal Government's Medical Research Future Fund (MRFF) Grants scheme to fund work with its industry partners to develop enabling technologies for manufacturing precision mRNA vaccines.

Key Points: 
  • SAN DIEGO and ADELAIDE, Australia, March 28, 2023 /PRNewswire/ -- BioCina , a leading contract development and manufacturing organization (CDMO), has been awarded a $5 million AUD grant under the Federal Government's Medical Research Future Fund (MRFF) Grants scheme to fund work with its industry partners to develop enabling technologies for manufacturing precision mRNA vaccines.
  • The project will help BioCina address the post-pandemic mRNA demand for specific and essential attributes of new personalized RNA products.
  • The project will help BioCina address the post-pandemic mRNA demand for specific and essential attributes of new personalized RNA products.
  • The first is an increase in mRNA manufacturing and associated analytical capability at BioCina, and the second is a microfluidics-based device for parallel manufacturing at the small scales required for the personalized therapeutic vaccines market.

Manhattan Construction Company Honored as Top Safety Leader Contractor by Associated Builders and Contractors

Retrieved on: 
Monday, March 27, 2023
Diamond, Manhattan Construction Company, General contractor, Culture, ABC Board, NAICS, CNA, NSEA, National Health, Associated Builders and Contractors, Construction, Gold, Pinnacle, ABC, American Industrial Hygiene Association, Health, Safety, Nightclub, Pharmaceutical industry, Platinum

TULSA, Okla., March 27, 2023 /PRNewswire-PRWeb/ -- Manhattan Construction Company (Manhattan) today announced it has earned a National Pinnacle Award from Associated Builders and Contractors, presented at the 33rd annual Excellence in Construction® Awards during ABC Convention 2023 in Orlando, Florida, on March 16.

Key Points: 
  • Manhattan Construction Company has earned a National Pinnacle Award from Associated Builders and Contractors.
  • TULSA, Okla., March 27, 2023 /PRNewswire-PRWeb/ -- Manhattan Construction Company (Manhattan) today announced it has earned a National Pinnacle Award from Associated Builders and Contractors, presented at the 33rd annual Excellence in Construction® Awards during ABC Convention 2023 in Orlando, Florida, on March 16.
  • This is the fifth time Manhattan has been honored with a National Safety Excellence Award (NSEA) and the third time to receive Pinnacle, the top honor.
  • "I am extraordinarily proud of Manhattan's safety culture," said Manhattan Construction Company President John Reyhan.