Researchers Identify Gene That Predicts Breast Cancer Patients' Treatment Outcomes
"Our study uncovered a gene that strongly associates with a patient's outcome after treatment with anthracyclines and anti-HER2 therapy, which may help oncologists formulate appropriate treatment strategies for patients with breast cancer based on their genetic makeup."
- "Our study uncovered a gene that strongly associates with a patient's outcome after treatment with anthracyclines and anti-HER2 therapy, which may help oncologists formulate appropriate treatment strategies for patients with breast cancer based on their genetic makeup."
- To make this discovery, the cancer researchers analyzed the DNA of 3,973 breast cancer patients from the Pathways Study, a large, multiethnic study of women undergoing treatment for breast cancer at Kaiser Permanente Northern California.
- The findings also highlight the potential of targeting both the UACA gene and the Par-4 pathway as new approaches to improving outcomes of patients with breast cancer.
- "It is amazing that we started with an agnostic search across the genome for genetic markers associated with breast cancer outcomes and identified UACA as a promising gene predictive of treatment outcomes for two commonly used agents for breast cancer," adds Dr. Yao.