Cold Spring Harbor Laboratory

Better cancer trials could be around the corner

Retrieved on: 
Thursday, March 21, 2024
Community, United States Census Bureau, Organization, Cold Spring Harbor Laboratory, COVID-19, Patient, Hospital, SPRING, Cancer, Northwell Health, Clinical trial, Census, Winkfield

When it comes to cancer trials, many variables impact patient participation.

Key Points: 
  • When it comes to cancer trials, many variables impact patient participation.
  • Janowitz and his team are now working to expand their analysis to other population segments and trials unrelated to cancer.
  • Winkfield, who co-authored the study, says:
    "We can do a much better job of providing access to clinical trials in the communities where it matters most.
  • Janowitz and Lee suggest applying their approach to design new cancer trials.

Why some RNA drugs work better than others

Retrieved on: 
Wednesday, March 6, 2024
Infant, Research, Drug development, Krainer, SMA, RNA, Risdiplam, Genome, Patient, SPRING, Pancreatic cancer, Cold Spring Harbor Laboratory, RNA splicing, CSHL, Vaccine

CSHL Associate Professor Justin Kinney, Krainer, and postdoc Yuma Ishigami have figured out why some splicing-based drugs tend to work better than others.

Key Points: 
  • CSHL Associate Professor Justin Kinney, Krainer, and postdoc Yuma Ishigami have figured out why some splicing-based drugs tend to work better than others.
  • To better understand how this drug works, the Kinney and Krainer labs analyzed risdiplam's interactions with RNA.
  • "Our new study provides insights into the action and specificity of splice-modifying drugs," Krainer says.
  • "This should facilitate the development of more effective drugs and drug combinations for a variety of diseases."

BREAKTHROUGH PRIZE FOUNDATION ANNOUNCES STUDENT WINNER OF NINTH ANNUAL BREAKTHROUGH JUNIOR CHALLENGE SCIENCE VIDEO COMPETITION

Retrieved on: 
Wednesday, February 7, 2024
Well, Tao, Physics, Breakthrough Initiatives, CNN, Breakthrough Prize, SAN, Selection Committee, ResearchGate, Harvard University, Prize, Research, Scripps Research, STEM, Genetics, Breakthrough, UCLA, Chemistry, University of California, Berkeley, Khan Academy, B cell, Shinsuke Yamanaka, Challenge, Breakthrough Prize in Mathematics, Interaction, Cold Spring Harbor Laboratory, Imagination, University, Student, Cancer, NASA, International Space University, Pharmaceutical industry

SAN FRANCISCO, Feb. 6, 2024 /PRNewswire/ -- The Breakthrough Prize Foundation today announced Sia Godika, 17, a senior at Neev Academy, an international school in Bangalore, India, as winner of the ninth annual Breakthrough Junior Challenge, a global science video competition designed to inspire creative thinking and communications skills around fundamental concepts in the life sciences, physics, and mathematics.

Key Points: 
  • The Breakthrough Junior Challenge will award a total of $400,000 in educational prizes for Sia, her science teacher, and her school.
  • Sia was informed of her win by her older brother Samay Godika, who is himself a previous winner of the Breakthrough Junior Challenge, topping the competition with his original video on circadian rhythms.
  • Having watched him receive the prize six years ago, Sia will now be honored alongside the 2024 Breakthrough Prize laureates at a ceremony in Los Angeles this spring.
  • Sia's submission is titled Yamanaka Factors, and explores discoveries made by 2013 Breakthrough Prize winner and Nobelist, Shinya Yamanaka.

BREAKTHROUGH PRIZE FOUNDATION ANNOUNCES STUDENT WINNER OF NINTH ANNUAL BREAKTHROUGH JUNIOR CHALLENGE SCIENCE VIDEO COMPETITION

Retrieved on: 
Wednesday, February 7, 2024
Well, Tao, Physics, Breakthrough Initiatives, CNN, Breakthrough Prize, SAN, Selection Committee, ResearchGate, Harvard University, Prize, Research, Scripps Research, STEM, Genetics, Breakthrough, UCLA, Chemistry, University of California, Berkeley, Khan Academy, B cell, Shinsuke Yamanaka, Challenge, Breakthrough Prize in Mathematics, Interaction, Cold Spring Harbor Laboratory, Imagination, University, Student, Cancer, NASA, International Space University, Pharmaceutical industry

SAN FRANCISCO, Feb. 7, 2024 /PRNewswire/ -- The Breakthrough Prize Foundation today announced Sia Godika, 17, a senior at Neev Academy, an international school in Bangalore, India, as winner of the ninth annual Breakthrough Junior Challenge, a global science video competition designed to inspire creative thinking and communications skills around fundamental concepts in the life sciences, physics, and mathematics.

Key Points: 
  • The Breakthrough Junior Challenge will award a total of $400,000 in educational prizes for Sia, her science teacher, and her school.
  • Sia was informed of her win by her older brother Samay Godika, who is himself a previous winner of the Breakthrough Junior Challenge, topping the competition with his original video on circadian rhythms.
  • Having watched him receive the prize six years ago, Sia will now be honored alongside the 2024 Breakthrough Prize laureates at a ceremony in Los Angeles this spring.
  • Sia's submission is titled Yamanaka Factors, and explores discoveries made by 2013 Breakthrough Prize winner and Nobelist, Shinya Yamanaka.

How a mouse's brain bends time

Retrieved on: 
Tuesday, January 30, 2024
Life, Banerjee, Learning, Music, Cold Spring Harbor Laboratory, Moon, Science, Neuron, Mouse, Imagination, SPRING, Behavior, Language, Singing, OMC, Brain, Education

So the question is, how does the brain do it."

Key Points: 
  • So the question is, how does the brain do it."
  • Now, Banerjee and collaborators have uncovered a new clue that suggests the brain bends our processing of time to suit our needs.
  • It might help explain how time is computed in other parts of the brain, allowing us to adjust various behaviors accordingly.
  • If everything was a stimulus-response, with no opportunity for learning, nothing that changes, no long-term goals, we wouldn't need a brain.

These worms have rhythm

Retrieved on: 
Wednesday, December 27, 2023
Cold Spring Harbor Laboratory, CSHL, Music, Protein, Mir-17 microRNA precursor family, SPRING, HHMI, Human, Brain, Pulse, Calculus, Cancer, Animal, Behavior, Gene expression, Curie Institute, Hammel (surname)

COLD SPRING HARBOR, N.Y., Dec. 27, 2023 /PRNewswire/ -- There's a rhythm to developing life.

Key Points: 
  • COLD SPRING HARBOR, N.Y., Dec. 27, 2023 /PRNewswire/ -- There's a rhythm to developing life.
  • Losing the rhythm can lead to diseases like cancer.
  • Cold Spring Harbor Laboratory (CSHL) Professor Christopher Hammell has found that in the worm C. elegans, this genetic orchestra has no single conductor.
  • Understanding how the worm's clock is regulated could help explain how time affects development in other animals.

Can we crack this cancer's immune response?

Retrieved on: 
Wednesday, November 29, 2023
Cold Spring Harbor Laboratory, Pancreatic cancer, Immunity, Antigen, Immune system, Cold, Pancreatic tumor, CSHL, Disease, B cell, Vaccination, Patient, Cancer, PDAC, Northwell Health, Pancreas, Future, Antibody, SPRING, Cell, Vaccine

It's thought patients do not show a natural immune response to the cancer because the tumor environment somehow prevents that response.

Key Points: 
  • It's thought patients do not show a natural immune response to the cancer because the tumor environment somehow prevents that response.
  • Many are unconvinced that PDAC interacts with the immune system at all.
  • CSHL scientists have now confirmed that pancreatic cancer does trigger a response in our immune system.
  • The idea was that the synthetic antibodies would point the team toward the new PDAC antigen behind the body's immune response .

18th Double Helix Medals dinner raises more than $10 million

Retrieved on: 
Monday, November 27, 2023
Cold Spring Harbor Laboratory, Invention, Renal cell carcinoma, Perception, DRS, Research, Howard Hughes Corporation, Double Helix Medal, CSHL, Medicine, Pershing Square Capital Management, Nobel Prize, Summa Corporation, MD Anderson Cancer Center, FDA, Immunotherapy, CBS, Lung cancer, Cancer, Natural history, Ipilimumab, Rivka Oxman, Entomology, American Museum, Museum, SPRING, Environment, Biology, Education, Pharmaceutical industry, Physiology

COLD SPRING HARBOR, N.Y., Nov. 27, 2023 /PRNewswire/ -- On November 15, Cold Spring Harbor Laboratory (CSHL) held its 18th annual Double Helix Medals dinner (DHMD) at the American Museum of Natural History in New York City.

Key Points: 
  • COLD SPRING HARBOR, N.Y., Nov. 27, 2023 /PRNewswire/ -- On November 15, Cold Spring Harbor Laboratory (CSHL) held its 18th annual Double Helix Medals dinner (DHMD) at the American Museum of Natural History in New York City.
  • CBS journalist Lesley Stahl returned to emcee the awards dinner, which honored Neri Oxman & William Ackman and 2018 Nobel laureate Jim Allison.
  • After receiving the Double Helix Medal, Oxman and Ackman announced an extraordinary gift, further breaking the event's fundraising record to support scientific research and education at CSHL.
  • Since the inaugural gala in 2006 honoring Muhammed Ali, the DHMD has raised over $60 million to support CSHL's biological research and education programs.

Cold Spring Harbor Laboratory rolls out STEM 'Bicycle Principles'

Retrieved on: 
Tuesday, November 21, 2023
Assistant, Dolan DNA Learning Center, Data management, STEM, DNA, Engineering, Mathematics, Cold, CSHL, Cold Spring Harbor Laboratory, Learning, Research, Science, University, Intercultural communication principles, Diversity, AI, SPRING, Meeting, Education, Nursing, Management

COLD SPRING HARBOR, N.Y., Nov. 21, 2023 /PRNewswire/ -- Success in science, technology, engineering, and mathematics (STEM) demands keeping up with the latest tools and techniques.

Key Points: 
  • COLD SPRING HARBOR, N.Y., Nov. 21, 2023 /PRNewswire/ -- Success in science, technology, engineering, and mathematics (STEM) demands keeping up with the latest tools and techniques.
  • Short training programs like webinars and boot camps have become a popular alternative among busy STEM professionals.
  • There's often no guarantee attendees will leave with the skills needed to advance their careers.
  • Williams is Assistant Director of Diversity and Research Readiness at the Cold Spring Harbor Laboratory (CSHL) DNA Learning Center .

You say genome editing, I say natural mutation

Retrieved on: 
Wednesday, November 8, 2023
Domestication, Human, CRISPR, Genetics, McCandlish, Cold Spring Harbor Laboratory, Nature, Computational biology, Learning, SPRING, CSHL, Genome, HHMI, Probability, Gene, Cold, Associate, Mutation

COLD SPRING HARBOR, N.Y., Nov. 8, 2023 /PRNewswire/ -- For tens of thousands of years, evolution shaped tomatoes through natural mutations .

Key Points: 
  • COLD SPRING HARBOR, N.Y., Nov. 8, 2023 /PRNewswire/ -- For tens of thousands of years, evolution shaped tomatoes through natural mutations .
  • Today, CRISPR genome editing allows us to make new crop mutations that improve traits even further.
  • And what if just one could dramatically alter the desired outcome of an engineered mutation?
  • (Natural mutation of this gene is known to increase fruit size.)