Larynx

• The event included presentations by members of the ARS Pharma management team and by two distinguished allergists, Dr. Jonathan Spergel, M.D., Ph.D. and Dr. Thomas B. Casale, M.D.
• Of the patients that do fill their prescription, 80-90% either do not carry or use their treatment as indicated.
• In late-February, the Company announced positive clinical data from a Phase 2 trial evaluating neffy in adults with chronic spontaneous urticaria.
• The webcast replay and accompanying slides from today’s investor event may be accessed through the Events & Presentations page in the Investors & Media section of the Company's website.

• The 76-year-old singer certainly delivered all his characteristic showmanship.
• Equally, it’s not all down to the process of ageing.

The sound of your voice

• The vocal cords are what produce the sound of your voice.
• When air passes out of the lungs and through the larynx, it causes the vocal cords to vibrate – producing sound.
• There are also approximately 17 other muscles in the larynx that can alter vocal cord position and tension – thus changing the sound produced.
• For instance, a woman’s voice may sound different depending on the stage of her menstrual cycle – with the best voice quality being in the ovulatory phase.

Everything ages

• As we get older, the larynx begins increasing its mineral content, making it stiffer and more like bone than cartilage.
• The muscles that allow the vocal cords to move also begin wasting (as do our other muscles) as we age.
• The ligaments and tissues that support the vocal cords also lose elasticity, becoming less flexible.

Lifestyle is a factor

• Smoking, for example, causes localised inflammation, increased mucous production, but can also dry out the mucosal surfaces.
• Blood thinners may also damage the vocal cords and can cause polyps to form, making the voice sound raspy or hoarse.
• One other lifestyle factor can be overuse, which is typically seen in singers and other people who use their voice a lot during work, such as teachers and fitness instructors.

Maintaining our vocal quality

• While we can’t help some of the age-related changes that happen to our vocal cords, we can maintain some of our vocal quality and ability through continued use.
• Singing or reading out loud daily can give the vocal cords sufficient exercise to slow their decline.

• During "Oral, Head and Neck Cancer Awareness Week," HNCA promotes a high volume of free oral, head and neck cancer screenings all over the world, plus educational talks, and other awareness programs.
• Head and neck cancer is a group of cancers affecting the oral cavity (mouth), larynx (voice box), pharynx (throat), sinuses, nasal cavity, or salivary glands.
• More than 65,000 Americans are diagnosed with head and neck cancer every year, with 14,600 lives lost.
• The Head & Neck Cancer Alliance's mission is to advance prevention, detection, treatment and rehabilitation of oral, head and neck cancer through public awareness, research and advocacy.

• Immunotherapy is an innovative treatment for cancer, including head and neck, lymphoma, melanoma, and non-small cell lung cancer.
• Based on the Therapy Type, the Head and Neck Cancer Therapeutics Market is segmented into Chemotherapy, Immunotherapy, and Targeted Therapy.
• Region-wise, the Head and Neck Cancer Therapeutics Market is analyzed across North America, Europe, Asia Pacific, and LAMEA.
• The North America segment registered the largest revenue share in the head and neck cancer therapeutics market in 2021.