Cannabidiol

• The RWE study revealed a meaningful improvement in overall Musculoskeletal Health Questionnaire scores (p
• The RWE study participants with an average age of 58 ± 15 (64% women) all presented with symptoms of chronic pain.
• Prior to initiation of the study, study participants reported they were taking an average of ten medications including NSAIDs, opioids, antidepressants, or skeletal muscle relaxants.
• Each RWE study participant was assigned a common treatment plan of a combination of a CBD oil (83.3%) or balance oil (16.7%) with the RHO Phyto CBG Transdermal Gel.

• Securities Commission (BCSC) issued a BC Notice today to raise awareness of a 2023 Commission decision about promotional disclosure, and how it must be presented to comply with the law.
• The BCSC panel's interpretation of the Act's requirement for clear and conspicuous disclosure was the first of its kind in Canada, and is binding on issuers and promoters in B.C.
• A link to another website containing the required disclosure requires readers "to take an extra step," the panel said.
• Companies and promoters should be aware of these expectations, which the BCSC will continue to enforce."

• LOUISVILLE, Colo., April 25, 2024 /PRNewswire/ - (TSX: CWEB) (OTCQX: CWBHF) Charlotte's Web Holdings, Inc. ("Charlotte's Web" or the "Company") the market leader in cannabidiol (CBD) hemp extract wellness products , will report its 2024 first quarter results prior to market open on May 8, 2024.
• A conference call to discuss the results is scheduled for the same day at 11:00 A.M. Eastern Time.
• To listen to a replay of the earnings call please dial 1-416-764-8677 or 1-888-390-0541 and provide conference replay ID 156359#.
• A webcast of the call will also be accessible through the investor relations section of the Company's website for an extended period of time.

• When other drugs would occasionally come up, I didn’t understand some of the slang terms they used for these drugs.
• Many people may have that feeling now when the topic of cannabis comes up – especially in its different and newer forms.
• A major change during my time in research is the legalization and explosion of cannabis availability across the U.S.

A shifting landscape

• It also serves as a catch-all term for any substance with chemical compounds from cannabis plants and addresses concerns that the word marijuana has some long-standing racist overtones.
• Cannabis now comes in a larger variety of forms than it used to.
• These include oils that can be vaporized by vape or dab pens, waxier substances and even powders.

How cannabis derivatives interact with the brain

• Each one interacts with the brain in different ways, producing different perceived effects.
• The differences between THC and CBD come from how they interact with cannabinoid receptors – the proteins onto which these drugs attach – in the brain and body.

The changing nature of cannabis products

• By increasing the amount of THC, concentrated products can increase blood levels of THC rapidly and more strongly than nonconcentrates such as traditional smoked cannabis.
• Cannabis concentrates also come in many different forms that range from waxy or creamy to hard and brittle.
• They are made in a variety of ways that may require dry ice, water or flammable solvents such as butane.
• The myriad names for cannabis concentrates can be confusing.

Cannabis use and adolescents

• A 2021 systematic review found that past-year cannabis vaping nearly doubled from 2017 to 2020 in adolescents - jumping from 7.2% to 13.2%.
• In addition, a 2020 study found that one-third of adolescents who vape do so with cannabis concentrates.
• Cannabis use by adolescents is scary because it can alter the way their brains develop.
• Adolescents who use cannabis are also more likely to experience symptoms of schizophrenia, struggle more in school and engage in other risky behaviors.
• This article is part of Legal cannabis turns 10, a series examining the impact of a decade of recreational cannabis use.

Ty Schepis receives funding from US Food and Drug Administration and the National Institute on Drug Abuse. His research is also supported by a faculty fellowship from the Texas State University Translational Health Research Center.