Pregabalin

• The patent, once granted, will not expire until at least 2034 and will become part of Vistagen’s global patent portfolio on therapeutic uses and manufacturing techniques for AV-101.
• In the study, AV-101 prodrug was systematically administered in four rat models of pain to examine its analgesic and behavioral profile.
• The preclinical study was conducted by Tony L. Yaksh, PhD, Professor of Anesthesiology and Pharmacology at the University of California, San Diego.
• Vistagen plans to seek potential strategic collaborations to further advance the clinical development and commercialization of AV-101.

• Where trips to the dentist flew by in a second and holidays felt like they lasted forever.
• Time altering pills may sound like science fiction but the time warping effects of psychoactive drugs suggest that deliberate time manipulation may be possible.
• Other drugs can scramble our sense of time completely.
• Pregabalin, a drug used to treat epilepsy and anxiety, and anti-anxiety drug Xanax, both slow
  the passage of time.

So why do drugs warp time?

• Drugs associated with increases in the passage of time are stimulants, which cause increased activity and excitation across the areas of the brain associated with cognitive function.
• Drugs also affect behaviour and emotions, both of which can twist our experience of time.
• Drugs such as cocaine and MDMA can have powerful effects on mood, inducing feelings of happiness and euphoria.
• What you do while taking drugs will contribute to the sensation that time is bending.

The aftermath

• The neurochemical, emotional and cognitive effects of comedowns create the perfect environment for time to drag.
• The combination of exhaustion and low mood means that much of the recovery period is spent wondering “when will this end”, which also exaggerates the slowing of time.

Intertwined with human history and nature

• They involve drinking a liquid brewed from leaves from the Psychotria viridis shrub and stalks of the Banisteriopsis caapi vine.
• The brew causes changes in the state of consciousness, resulting in hallucinations and a significant change in the flow of time.
• Nowadays, ayahuasca ceremonies attract tourists from across the world seeking to experience altered states of consciousness and spirituality.
• Ruth Ogden receives funding from receives funding from The British Academy, The Wellcome Trust, The Economic and Social Research Council and CHANSE.

• As per DelveInsight analysis, the acute pain market size in the US was approximately USD 3 billion in 2021.
• According to the assessment done by DelveInsight, the estimated total acute pain cases in the US was approximately 100 million in 2021.
• As per the DelveInsight estimates, in the US, in 2021, diagnosed incident cases of acute pain were approximately 94 million.
• The acute pain market report proffers epidemiological analysis for the study period 2019–2032 in the 7MM segmented into:

• The report offers strategic insights into the overall Peripheral Neuropathy market along with the market size and estimates for the duration 2022 to 2030.
• The drug types studied for analyzing the overall global peripheral neuropathy market are segmented into pharmacological therapies and non-pharmacological therapies.
• Among antidepressants, Amitriptyline is widely recommended for neuropathic pain and thus dominates the peripheral neuropathy antidepressant market.
• Asia Pacific would exhibit the fastest growth rate in the Global Peripheral Neuropathy market due to aging population, increasing health awareness and high prevalence of the diabetes, cancer and HIV/AIDS.