Liver stage antigens

Rational Vaccines' Herpes Vaccine RVx1001 Shows Promise as a Viral Vector Platform to Express Malaria Proteins and Confer Protection against Malaria Infection in Mice According to a Recent Study Published in Vaccines

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Tuesday, May 10, 2022
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WOBURN, Mass. and OXFORD, England, May 10, 2022 /PRNewswire/ -- Rational Vaccines, a company focused on revolutionizing the treatment and prevention of herpes to eradicate the disease, today announced that the Company's attenuated herpes simplex virus type-1 (HSV-1)-vaccine RVx1001 can be utilized as a viral vaccine vector to protect against malaria infections.

Key Points: 
  • Research shows company's novel HSV-1-derived viral vaccine has significant potential to produce vaccines to combat infectious diseases including malaria.
  • The study, "An Attenuated HSV-1 Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection Against Infectious Sporozoite Challenge," was published in Vaccines and can be accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875294/
    The published study reported on the development of a highly efficacious trivalent malaria vaccine using the Rational Vaccines RVx1001 vaccine as a vector.
  • The construction of the HSV-1 vectored vaccine expressed three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3, and TMP21) as fusion proteins with the VP26 viral capsid protein.
  • "These data show that the Rational Vaccines HSV-1 vaccine can be effectively utilized as a vector platform to protect against malaria and other infectious diseases.