Sandler Foundation

Immune Response to COVID-19 Vaccine Different with Prior Infection

Retrieved on: 
Tuesday, October 12, 2021

Antibodies produced by the immune system's B cells can quickly recognize a virus, target it for destruction, and prevent infection.

Key Points: 
  • Antibodies produced by the immune system's B cells can quickly recognize a virus, target it for destruction, and prevent infection.
  • While antibodies are more effective at stopping initial infection completely, T cells generally last longer after an initial infection or vaccine and can help quell disease in its early stages, preventing severe symptoms.
  • Distinct subsets of T cells respond differently to infected cells and have different functions within the overall T cell response.
  • However, in those who had previously had a COVID-19 infection, there was little change between the first and second dose of the vaccine.