Université de Montréal

Bayer Starts Phase I Study With Novel Targeted Radionuclide Therapy 225Ac-PSMA-Trillium in Advanced Metastatic Prostate Cancer

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星期三, 五月 15, 2024
Research, Fitness & Nutrition, Clinical Trials, Other Health, Biotechnology, Pharmaceutical, Health, Science, Oncology, Other Science, Patient, Survival, Surgery, PSMA, Prostate cancer, University, AACR, FRCS, Trial of the century, Disease, Université de Montréal, Safety, Gland, Horizon, MD, CHUM, Cancer, Professor, Bayer, Actinium-225, Pharmaceutical industry

Bayer announced today initiation of dosing in a Phase I first-in-human clinical study with 225Ac-PSMA-Trillium (BAY 3563254), a next-generation targeted alpha therapy.

Key Points: 
  • Bayer announced today initiation of dosing in a Phase I first-in-human clinical study with 225Ac-PSMA-Trillium (BAY 3563254), a next-generation targeted alpha therapy.
  • The dose-escalation study ( NCT06217822 ) will evaluate the safety, tolerability and efficacy of 225Ac-PSMA-Trillium in patients with advanced metastatic castration resistant prostate cancer (mCRPC).
  • “We are excited to announce initiation of the phase I and dosing of the first patient with 225Ac-PSMA-Trillium.
  • With its unique design, we believe it could offer a meaningful benefit for patients with metastatic prostate cancer, and we look forward to advancing the program through clinical development.”
    Prostate cancer is the second most commonly diagnosed cancer in men1 and a key area of focus at Bayer.

New Publication in Nature Medicine Supports Therapeutic Potential of Senolytics to Provide Long-lasting, Disease-modifying Intervention in Vision Loss

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星期二, 二月 6, 2024
Biotechnology, Paper, SAN, Cell, Research, VEGF, Therapy, Ageing, Environment, Patient, Diabetic retinopathy, Hyperglycemia, Unity Biotechnology, Retina, Homeostasis, Visual acuity, UBX, Cellular senescence, Diabetes, Endothelium, DME, University, Eye, Metalloproteinase, Nature Medicine, Université de Montréal, Pharmaceutical industry

Sustained hyperglycemia from diabetes induces cellular senescence which damages the retina, including the delicate vasculature in the eye.

Key Points: 
  • Sustained hyperglycemia from diabetes induces cellular senescence which damages the retina, including the delicate vasculature in the eye.
  • This can lead to fluid accumulation and retinal thickening – a key feature of DME.
  • They demonstrated that these senescent cells contribute to loss of barrier function, which can cause leaky blood vessels.
  • This research further supports the potential for senolytic medicines to address the significant unmet need with current standard of care.”

XTANDI® (enzalutamide) Receives Health Canada Approval as the First and Only Treatment for High-Risk Patients with Non-Metastatic Castration-Sensitive Prostate Cancer (nmCSPC)

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星期二, 一月 30, 2024
Orbis, Patient, Prostate cancer, BCR, Therapy, Professor, MFS, Radiation, University, Cancer, Recurrence, Metastasis, Acquisition, Université de Montréal, ADT, New Drug Application, Gonadotropin-releasing hormone, Health Canada, Prostate, Diagnosis, Physician, Pharmaceutical industry

MARKHAM, ON, Jan. 30, 2024 /CNW/ - Today, Astellas Pharma Canada, Inc. announced that Health Canada has approved a supplemental New Drug Application for XTANDI® (enzalutamide) in a new prostate cancer treatment setting.

Key Points: 
  • MARKHAM, ON, Jan. 30, 2024 /CNW/ - Today, Astellas Pharma Canada, Inc. announced that Health Canada has approved a supplemental New Drug Application for XTANDI® (enzalutamide) in a new prostate cancer treatment setting.
  • "I welcome the approval of XTANDI as a promising earlier treatment option for eligible patients.
  • This marks a significant step forward in addressing unmet needs for prostate cancer treatment."
  • With our recent acquisition of Propella Therapeutics, Inc., we strive to achieve even more in the investigation of targeted prostate cancer treatments for patients of the future."

Linearis Opened its New Laboratory Offering an AI Biomarkers Analytical Platform for Innovation Against Cancer, Diabetes, Antimicrobial Resistance, and Other Metabolic Diseases

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星期二, 十一月 28, 2023
Université de Montréal, Press Conference (TV program), Mass spectrometry, AP-HP, IRIC, Université Laval, Acceleration, INAF, Medicago Inc., Biotechnology, DSM-IV codes, TMIC, Medicine, McGill University, Conference, Voltigeur, University, Drug discovery, FRQ, Cancer, Biomarker, AI, Diabetes, Metabolomics, University of Ottawa, Medical device, Pharmaceutical industry, Chomatodus, Operation Axe, Medicago

Leveraging artificial intelligence (AI), Linearis provides a comprehensive health status based on the analysis of 1,400 metabolomic biomarkers through mass spectrometry.

Key Points: 
  • Leveraging artificial intelligence (AI), Linearis provides a comprehensive health status based on the analysis of 1,400 metabolomic biomarkers through mass spectrometry.
  • The platform will enable its clients to improve prevention, screening, treatment monitoring, and new drug discovery.
  • The combination of AI and high-throughput automated analysis of 1,400 metabolomic biomarkers enables Linearis to better identify numerous elements associated with metabolic diseases including cancer, diabetes, and antimicrobial resistance.
  • "We are grateful for the support from Medicago during this transaction enabling the creation of this innovative and collaborative laboratory.

Using genomics to reduce the carbon footprint of the agri-food industry

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星期三, 九月 6, 2023
Genome Canada, Genomics, Fertilizer, Fishery, Parafilm, Centrale, Fungus, Science, Forestry, Transport, INRS, David Suzuki Foundation, Waste management, Ivey Business School, Research, Government, Tricycle, Compost, McGill University, Local government in Canada, Université de Montréal, Bacteria, Treasury Board of Canada, Environment and Climate Change Canada, LOOP, DNA, Biotron (Western University), Climate change, Carbon, Montreal Botanical Garden, The Wilderness Society, Climate change mitigation, Environment, Greenhouse, Food, Western University, Agriculture, University, Park, City, Food chain, CO2, Farm, Cryptocurrency, Management, Landfill, Renewable energy, Municipality of the County of Inverness

With that in mind, new approaches are essential to reduce the carbon footprint of the country's agri-food sector.

Key Points: 
  • With that in mind, new approaches are essential to reduce the carbon footprint of the country's agri-food sector.
  • In other words, how are agri-food byproducts or food leftovers biodegraded by microorganisms, fungi or insects that feed on them?
  • Their expertise will help us reduce the carbon footprint of Canada's food production systems while continuing to develop innovation."
  • As a result of their work, the research teams will propose biotechnological innovations to reduce the carbon footprint of Canada's bio-food production systems.

EQS-News: DEFENCE THERAPEUTICS AND CQDM FUND THE DEVELOPMENT OF A NEW CANCER VACCINE PLATFORM

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星期五, 二月 3, 2023
B cell, Defense, Cancer, World Cancer Day, Therapy, Economic development, General Hospital, Immunotherapy, Biotechnology, Melanoma, Quality of life, Université de Montréal, Dugas, Vaccine, Organization, Infection, Workforce Innovation in Regional Economic Development, Bureau of Oceans and International Environmental and Scientific Affairs, Patient, Minister responsible for the Montreal region (Quebec), Innovation, Stem cell, Jewish General Hospital, Pharmaceutical industry, QC, Metropolis, Accum

“By conducting collaborative research, such as that done by Dr. Rafei’s team, new therapeutic strategies and new vaccines can be developed.

Key Points: 
  • “By conducting collaborative research, such as that done by Dr. Rafei’s team, new therapeutic strategies and new vaccines can be developed.
  • “CQDM is pleased to contribute to the efforts of the biotechnology company Defence Therapeutics by supporting the development of an all-new vaccine approach that promotes more effective presentation of tumour antigens to immune effector cells," said Véronique Dugas, Vice President of Scientific Affairs at CQDM.
  • “The versatility of Accum technology is what continually drives Defence Therapeutics to be on the cutting-edge and to excel in the development of novel innovative strategies to successfully fight against several types of cancer," said Sébastien Plouffe, president of Defence Therapeutics.
  • It is expected that this technology will be simpler and less expensive to produce compared with other approaches now in development.

AI and Cities: UN-Habitat and Mila launch a collaborative White Paper on the use and potential challenges of AI to support the development of people-centered sustainable cities and settlements

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星期二, 十月 4, 2022
United Nations, Solution, White paper, Doctor of Philosophy, City, Achievement, UN-Habitat Scroll of Honour Award, Technology, Learning, Poverty, Public policy, Research, UEF, Neglected tropical diseases, Knowledge, Law, Université de Montréal, CEO, 1969 White Paper, Multimedia, WUP, Deep learning, Society, Artificial intelligence, UN, Energy, Tilburg Institute of Comparative and Transnational Law, Machine learning, EDT, University, AI, Urbanization, United Nations Human Settlements Programme, Medical device, Online shopping, Medicine, Agriculture, Health care

), and covers important themes including the trad-offs and risks of AI, the specific approaches and applications of urban AI in urban governance.

Key Points: 
  • ), and covers important themes including the trad-offs and risks of AI, the specific approaches and applications of urban AI in urban governance.
  • The paper will be unveiled during a panel discussion at the 2022 Urban Economy Forum (UEF) in Toronto.
  • "AI, like any other technology, can be a force that widens or reduces social gaps depending on how it is applied.
  • "This White Paper could be a very useful tool for local authorities who, like UN-Habitat and Mila, are committed to the responsible development of AI."

AI and Cities: UN-Habitat and Mila launch a collaborative White Paper on the use and potential challenges of AI to support the development of people-centered sustainable cities and settlements

Retrieved on: 
星期二, 十月 4, 2022
United Nations, Solution, White paper, Doctor of Philosophy, City, Achievement, UN-Habitat Scroll of Honour Award, Technology, Learning, Poverty, Public policy, Research, UEF, Neglected tropical diseases, Knowledge, Law, Université de Montréal, CEO, 1969 White Paper, WUP, Deep learning, Society, Artificial intelligence, UN, Energy, Tilburg Institute of Comparative and Transnational Law, Machine learning, EDT, University, AI, Urbanization, United Nations Human Settlements Programme, Medical device, Online shopping, Medicine, Agriculture, Health care

), and covers important themes including the trad-offs and risks of AI, the specific approaches and applications of urban AI in urban governance.

Key Points: 
  • ), and covers important themes including the trad-offs and risks of AI, the specific approaches and applications of urban AI in urban governance.
  • The paper will be unveiled during a panel discussion at the 2022 Urban Economy Forum (UEF) in Toronto.
  • "AI, like any other technology, can be a force that widens or reduces social gaps depending on how it is applied.
  • "This White Paper could be a very useful tool for local authorities who, like UN-Habitat and Mila, are committed to the responsible development of AI."

Andy Nong Joins ScitoVation as Director of Computational Toxicology

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星期一, 七月 11, 2022
Partnership, Nong, Economy, Toxicology, Risk assessment, Chemical industry, CEO, NAS, National Academies of Sciences, Engineering, and Medicine, Industry, NAM, Ecosystem, Doctor of Philosophy, Outline of health sciences, Household, Publication, University, Minister of Health (Canada), Environment, Exposure, European Menopause and Andropause Society, Organisation for Economic Co-operation and Development controversy, Chemical safety, Drinking water, Organization, National Institute of Environmental Health Sciences, Society, Public health, Research, Journal, OECD, Editing, Université de Montréal, Board, Laboratory, State Research Bureau (organisation), Health Canada, National academy, Management, Medical device, Development

DURHAM, N.C., July 11, 2022 /PRNewswire-PRWeb/ -- ScitoVation announced today the new Director of Computational Toxicology, Andy Nong PhD, formerly Health Canada's Acting Manager of the Exposure and Biomonitoring Division and Principal Research Scientist for the Computational Toxicology Laboratory of the Environmental Health Sciences and Research Bureau.

Key Points: 
  • DURHAM, N.C., July 11, 2022 /PRNewswire-PRWeb/ -- ScitoVation announced today the new Director of Computational Toxicology, Andy Nong PhD, formerly Health Canada's Acting Manager of the Exposure and Biomonitoring Division and Principal Research Scientist for the Computational Toxicology Laboratory of the Environmental Health Sciences and Research Bureau.
  • Dr Nong is excited to join ScitoVation and lead its excellent computational experts.
  • He explained, "I am thrilled to become part of the talented Scitovation team and provide guidance on computational research for New Approach Methods (NAM).
  • In addition to his research activities, Dr Nong is the former past president for the Society of Toxicology Biological Modeling Speciality Section.

NASA Updates Coverage for Webb Telescope's First Images Reveal

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星期四, 七月 7, 2022
EDT, NASA TV, Science, Space Telescope Science Institute, NASA Headquarters, CSA, French Guiana, James Webb Space Telescope, Social media, NASA Social, COVID-19, Montreal, Spectroscopy, Canadian Space Agency, ESA, Policy, NASA, Goddard Space Flight Center, Partnership, YouTube, University, Accreditation, Solar System, Galaxy, Webb's, Université de Montréal, Interview, Instagram, European Space Agency, Dailymotion, Twitter, Comment, Communications satellite, Online shopping, Public relations, Facebook

9:45 a.m. Live, opening remarks by agency and Webb leadership will air on NASA TV, the NASA app, and the agency's website ahead of the first images release.

Key Points: 
  • 9:45 a.m. Live, opening remarks by agency and Webb leadership will air on NASA TV, the NASA app, and the agency's website ahead of the first images release.
  • 10:30 a.m. Live coverage of the image release broadcast will air on NASA TV, the NASA app, and the agency's website .
  • Following the live broadcast, NASA and its partners will hold a joint media briefing at NASA Goddard.
  • Webb experts will answer questions about the first images and data in a NASA Science Live show.