Reinnervation

Regeneration and Reinnervation of Spinal Cord in Rats Treated with NurExone's Intranasal ExoPTEN

Retrieved on: 
Thursday, June 22, 2023
Rat, Magnetic resonance imaging, DTI, Tetraplegia, Spinal cord, Survival, Diffusion MRI, FSE, Research, NRX, TEL, Reinnervation, MRI, Regeneration, Animal, Patient, Neuroregeneration, Nasal administration, Exosome, FA, SCI, Trauma, Trapping, Medical imaging

The image analysis and measurements confirmed successful nerve regeneration following traumatic transection of the spinal cord in rats.

Key Points: 
  • The image analysis and measurements confirmed successful nerve regeneration following traumatic transection of the spinal cord in rats.
  • Subsequently, the spinal cords of rats from the study were subjected to advanced Diffusion Tensor Imaging (DTI) to assess the structural integrity of the spinal cord.
  • ExoPTEN is being developed to be a minimally invasive ExoTherapy for spinal cord injuries (SCI) administrated intranasally and yielding neuron regeneration and rewiring in traumatically damaged spinal cords.
  • These DTI tractography images and measurements indicate re-innervation and nourishment to the caudal spinal cords in ExoPTEN rats treated intranasally.

Checkpoint Surgical Devices Are Key Component In New Surgical Procedure Providing Relief For Amputees Suffering With Limb Pain

Retrieved on: 
Wednesday, February 12, 2020
Medicine, Perception, Acute pain, Phantom pain, Neurological disorders, Pain, Amputation, Phantom limb, Reinnervation, Prosthesis

Recently, a surgical procedure known as Targeted Muscle Reinnervation (TMR) provides amputees with new hope for relief from pain.

Key Points: 
  • Recently, a surgical procedure known as Targeted Muscle Reinnervation (TMR) provides amputees with new hope for relief from pain.
  • "Our nervous system is like an electric grid, and severed nerves are like live wires that cause pain," Dr. Dumanian said.
  • The study found TMR resulted in a significantly greater reduction in phantom limb pain and a trend toward improved residual limb pain compared to standard treatment.
  • Targeted muscle reinnervation treats neuroma and phantom pain in major limb amputees: a randomized clinical trial.