Thymine

Synthetic DNA Sheds Light on Mysterious Difference Between Living Cells at Different Points in Evolution

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水曜日, 3月 6, 2024
Human services, Nature, Engineering, Fungus, Sol, Nonsense, Doctor of Philosophy, HPRT1, CpG, DNAS, Health, Noise, Genetic code, Thymine, Letter, Cell, Factorization of polynomials, RNA, Human, Adenosine, NYU Langone Health, Genome, Protein, Gene, Genomics, Genetics, Accident, NHGRI, DNA, Mouse, Vaccine

Is it just noise, a side effect of evolution, or does it have functions?

Key Points: 
  • Is it just noise, a side effect of evolution, or does it have functions?
  • A research team at NYU Langone Health sought to answer the question by creating a large, synthetic gene, with its DNA code in reverse order from its natural parent.
  • Then they put synthetic gene into yeast and mouse stem cells and watched transcription levels in each.
  • The study authors use yeast cells to assemble long DNA sequences in a single step, and then deliver the them into mouse embryonic stem cells.

Quantum dots are part of a revolution in engineering atoms in useful ways – Nobel Prize for chemistry recognizes the power of nanotechnology

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水曜日, 10月 4, 2023
Television, Heart, Technology, Nobel Prize, Lighting, Hair, DNA, Human, Guanine, Thymine, Light, Adenine, Nanotechnology, Toxicity, Research, RNA, Quantum dot, Trade and Technology Council, Chemistry, Cytosine, Quantum, Engineering, Morality, Reading, Physics, Biology, Color, Environment, Safety, Microscope, Electronics, Nobel

The 2023 Nobel Prize for chemistry isn’t the first Nobel awarded for research in nanotechnology.

Key Points: 
  • The 2023 Nobel Prize for chemistry isn’t the first Nobel awarded for research in nanotechnology.
  • But it is perhaps the most colorful application of the technology to be associated with the accolade.
  • This year’s prize recognizes Moungi Bawendi, Louis Brus and Alexei Ekimov for the discovery and development of quantum dots.
  • Quantum dots brilliantly fluoresce: They absorb one color of light and reemit it nearly instantaneously as another color.

Skip chemical bonds, rely on quantum physics

    • For instance, some of the earliest dyes started with a clear substance such as analine, transformed through chemical reactions to the desired hue.
    • Rather than depending on chemical bonds to determine the wavelengths of light they absorb and emit, they rely on very small clusters of semiconducting materials.
    • Early quantum dots were often based on cadmium selenide for instance – the component materials of which are toxic.
    • And yet, quantum dots are a pivotal part of a technology transition that’s revolutionizing how people work with atoms and molecules.

‘Base coding’ on an atomic level

    • This concept is intuitive when it comes to computing, where programmers use the “base code” of 1,s and 0’s, albeit through higher level languages.
    • This ability to work with base codes also extends to the material world.
    • Here, the code is made up of atoms and molecules and how they are arranged in ways that lead to novel properties.
    • Bawendi, Brus and Ekimov’s work on quantum dots is a perfect example of this form of material-world base coding.

New research reveals that Ötzi the iceman was bald and probably from a farming family – what else can DNA uncover?

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木曜日, 8月 24, 2023
DNA, Hair, Human, University, Diet, South Tyrol Museum of Archaeology, Body composition, Guanine, Genetics, Iceman, Hair loss, HERC2, MC1R, Thymine, Adenine, Permafrost, Research, Temperature, Cell, Metallurgy during the Copper Age in Europe, Genetic code, Chalcolithic, Cytosine, Portrait, Twin, Chromosome, Max Planck Institute for Evolutionary Anthropology, Battle, University of Leicester, Death, Environment, Gene, Max Planck Society, Skin, Genome, Disease, Medicinal plants, Computer data storage, Tourism, Phosphorus, Dietary supplement, Cosmetics, Archaeology

This amazing find would subsequently become known as Ötzi the Iceman.

Key Points: 
  • This amazing find would subsequently become known as Ötzi the Iceman.
  • His body and belongings were extensively studied, prompting numerous questions: what was he doing here?
  • His unique preservation enabled the sequencing of Ötzi’s whole genome – the complete “instruction booklet” for building a human.
  • But it was enough for a team led by Turi King at the University of Leicester to extract fragments of DNA from them.

Crime scene samples

    • Sequencing a genome, which comprises billions of DNA bases, enables scientists to evaluate regions of the human genome that contribute to appearance.
    • For more than 30 years, forensic scientists have looked at specific highly variable regions in DNA to match these to crime scene samples, or to relatives of a suspect or victim.
    • So how likely is it that DNA from such a sample could accurately paint a picture of me?
    • Can forensic scientists build a kind of identikit photo from a crime scene DNA sample?
    • Hair colour can be predicted from DNA, but darker shades of hair are more accurately predicted than blonde hair.

Environmental factors

    • Commercially sold laboratory kits such as Hirisplex can simultaneously evaluate several DNA regions to predict the hair and eye colour from a biological sample.
    • However, unlike eye colour, hair colour prediction from DNA is only of value until midlife, when the natural processes of ageing lead to greying or white hair.
    • These processes also lead to hair loss in some people and more than 300 gene variants have been linked to baldness.
    • More representative data from the rest of the world will therefore enhance studies in forensic archaeology, such as the Ötzi research.

BioVie Issues Letter to Shareholders

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火曜日, 7月 18, 2023
Insulin resistance, Methylation, Guanine, Enzyme, Genetic code, Hypercholesterolemia, Cytosine, Plasma, Protein, Patient, Sound, DNA methylation, American Diabetes Association, Environment, Antioxidant, Disease, Horváth, Diet, Hypertriglyceridemia, Genetics, Human, DVD, Thymine, Public key certificate, Ageing, Adenine, Brain, Gene expression, Dementia, Homeostasis, Nucleoside, Hypertension, Oxidative stress, DSM-IV codes, Map, Overweight, CSF, Diagnosis, CpG, Human Genome Project, Conference, Behavior, Genome, Cognition, Exercise, COPD, DNA, Dementia 13, Deficit spending, Biomarker, Cell, MCI, Downregulation and upregulation, ADAS, Letter, MMSE, Cell death, Phosphorylation, Inflammation, Neuron, DNaM, AD, Health, Gene, Medical imaging, Pharmaceutical industry, Vaccine, Illumina

Over 3,000 significant correlations were found linking reductions in DNA methylation of various CpGs and cognitive, biomarker and neuroimaging endpoints.

Key Points: 
  • Over 3,000 significant correlations were found linking reductions in DNA methylation of various CpGs and cognitive, biomarker and neuroimaging endpoints.
  • I have prepared this letter to shareholders to provide an update that synthesizes all the information that we have released and presented at recent medical conferences.
  • NE3107 reduced CSF phospho-tau levels by -1.66 pg/mL (p=0.0343) and the ratio of p-tau to amyloid beta 42 (Aβ42) by -0.0024 (p=0.0401).
  • P-tau and Aβ are traditional biomarkers of AD progression and have been the focus for AD researchers for decades.

Cellectis Showcased Preclinical Data at an Oral Presentation and Two Poster Presentations at the 29th International Society for Cell & Gene Therapy (ISCT 2023) Annual Event

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月曜日, 6月 5, 2023
Graft-versus-host disease, HD, Antigen, DNA, BP, TRAC, HSPC, Euronext Growth, Interferon gamma, UGI, CD19, Red blood cell, ISCT, Lymphoid leukemia, CD20, Neoplasm, Thymine, Patient derived xenograft, Survival, Gene editing, Bone marrow, CD52, CD22, Deamination, Toxicity, Cell, Stem cell, PDX, CAR, Patient, Risk, Engineering, International Society, Knowledge, HBB, TALEN, TC, Phenotype, Vaccine, Online shopping, Cosmetics, HBSS, Cellectis, Cytosine

The therapeutic options after CAR T-cell relapses are limited, emphasizing the need to develop novel therapies to improve current survival rates.

Key Points: 
  • The therapeutic options after CAR T-cell relapses are limited, emphasizing the need to develop novel therapies to improve current survival rates.
  • UCART20x22 is Cellectis’ first dual-targeting, allogeneic cell therapy product candidate targeting CD20 and CD22, to address the current challenges in the treatment of B-cell malignancies.
  • The oral presentation highlighted the following preclinical data:
    Robust in vitro and in vivo cytolytic activity against tumors expressing different antigen combinations.
  • The oral presentation is available on Cellectis’ website: https://www.cellectis.com/en/investors/scientific-presentations/
    Sickle cell disease stems from a single point mutation in the HBB gene which results in sickle hemoglobin.

The Worldwide Bioinformatics Industry is Expected to Reach $46.8 Billion by 2027 - ResearchAndMarkets.com

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火曜日, 8月 30, 2022
Health, General Health, Titan, Partnership, COVID-19, Technology, Research, TIMS, Vaccine, Adenine, Nucleotide, Cytosine, Bioinformatics, Disease management, DNA, Bruker, Workflow, Method, Protein, Thymine, Acquisition, Growth, Guanine, Proteomics, Fine chemical, Phosphorus, Pharmaceutical industry, Animal, Biostatistics

The rising demand for both nucleic acid and protein sequencing is the key driving factor for the Bioinformatics market.

Key Points: 
  • The rising demand for both nucleic acid and protein sequencing is the key driving factor for the Bioinformatics market.
  • Protein sequencing is the practical process of determining the amino acid sequence of all or parts of a protein or peptide.
  • However, higher costs associated with the bioinformatics software and services and dearth of skilled professionals may be certain limiting factors of the Bioinformatics market growth.
  • Which are the regions and countries where companies should have concentrated on opportunities for Bioinformatics market growth in the coming future?

Outlook on the DNA Sequencing Products Global Market to 2027 - by Product Type, Application, End-user, Technology and Region - ResearchAndMarkets.com

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木曜日, 7月 14, 2022
Health, Genetics, Milk, Precision medicine, Meat, Gene, Animal, Protein sequencing, Sheep, Genome, Guanine, Adenine, Whole genome sequencing, Patient, Thymine, COVID-19, Bacteria, Diagnosis, Livestock, Research, Cytosine, DNA, Optical instrument, Vaccine, Fine chemical, Illumina

Which are the popular product types in the global DNA sequencing products market?

Key Points: 
  • Which are the popular product types in the global DNA sequencing products market?
  • What are the various stages in the value chain of the global DNA sequencing products market?
  • What is the structure of the global DNA sequencing products market and who are the key players?
  • What is the degree of competition in the global DNA sequencing products market?

Thymidylate Synthase Inhibitors Pipeline Market Report 2022: Insights About 18+ Companies and 18+ Pipeline Drugs Including Emerging Drugs - ADX 2191: Aldeyra Therapeutics and LY-01616: Luye Pharma - ResearchAndMarkets.com

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月曜日, 1月 31, 2022
Health, Pharmaceutical, Methylation, DNA, III, Patient, Therapy, Clinical trial, Discovery, PVR, II, Dump, Thymine, Downregulation and upregulation, News, Irinotecan, Thymidine, Administration, Methotrexate, Generic drug, Pharmaceutical industry, Thymidine monophosphate, N5, RNA

This "Thymidylate synthase inhibitors - Pipeline Insight, 2022" report provides comprehensive insights about 18+ companies and 18+ pipeline drugs in Thymidylate synthase inhibitors pipeline landscape.

Key Points: 
  • This "Thymidylate synthase inhibitors - Pipeline Insight, 2022" report provides comprehensive insights about 18+ companies and 18+ pipeline drugs in Thymidylate synthase inhibitors pipeline landscape.
  • Thymidylate synthase is an important enzyme, which is responsible for the reductive methylation of deoxyuridylic acid (dUMP) to deoxythymidylic acid (dTMP).
  • The companies and academics are working to assess challenges and seek opportunities that could influence Thymidylate synthase inhibitors R&D.
  • The companies which have their Thymidylate synthase inhibitors drug candidates in the most advanced stage, i.e.