Homeostasis

• SAN FRANCISCO, May 31, 2024 (GLOBE NEWSWIRE) -- Generation Lab , the first longevity platform to measurably extend the human lifespan, today announced the general availability of its groundbreaking offering: the first platform that measures aging speed, biomarkers for disease, and top aging factors.
• It offers personalized action plans aimed at cell regeneration across key organs and systems to slow or even reverse aging.
• One of the first longevity clinics to partner with Generation Lab was New York City’s Extension Health (formerly known as Hudson Health).
• The Generation Lab platform is available for purchase online or via one of the dozens of longevity clinics across the U.S. in our affiliate program.

• Since June 2023, Sophos X-Ops has discovered 19 ‘junk gun’ ransomware variants—cheap, independently produced and crudely constructed ransomware variants—on the dark web.
• The developers of these junk gun variants are attempting to disrupt the traditional affiliate-based ransomware-as-a-service (RaaS) model that has dominated the ransomware racket for nearly a decade .
• Junk gun ransomware discussions are taking place primarily on English-speaking dark web forums aimed at lower-tier criminals, rather than well-established Russian-speaking forums frequented by prominent attacker groups.
• To learn more about junk gun ransomware and the latest change in the ransomware ecosystem, read “’Junk Gun’ Ransomware: Peashooters Can Still Pack a Punch” on Sophos.com .

• The first study investigated the use of metformin (Met), a drug used to manage type II diabetes, for treating benign prostate hyperplasia (BPH).
• The article was published in Volume 14, Issue 1 of the journal in January 2024 .
• Using the Drug Signatures Database, they identified hydralazine (HYD), a potent arterial vasodilator, as a potential UBA52 disruptor.
• Further studies will hopefully clarify the intricate connections among cellular processes, diseases, and potential drugs, paving the way for precise and efficient therapies.

• Research has shown that changes to the composition and diversity of the microorganisms in the gut may explain these differences in immune system aging.
• However, as the composition of our gut microbiome changes with age, a low level of inflammation can become constant throughout the body.
• Let’s take a closer look at the gut microbiome and how it changes with age.

Gut microbiome imbalances in older adults

• In fact, compared to other parts of the body, the gut microbiome has the largest number of bacteria.
• In a healthy gut microbiome, there are four dominant families (or phyla) of microorganisms, including Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria.
• Firmicutes and Bacteroidetes make up around 80 to 90 per cent of the gut microbiota in the digestive tract.
• Over time, the shortage of beneficial bacteria such as Firmicutes in older adults starts to compromise the integrity of their intestinal barrier, causing it to become leaky.

How inflammaging works

• Inflammaging creates an environment that is prone to inflammation, which is caused and maintained by several factors.
• These can include microorganism imbalances in the intestines (microbial dysbiosis), psychological stress, physical inactivity, poor nutrition and chronic infections.

Maintaining a healthy balance of gut microbiota

• More specifically, probiotics help improve the function of the intestinal barrier and regulate immune responses by modifying the composition of the gut microbiome.
• It is clear that the immune system has an intricate relationship with the gut microbiome.
• A healthy and well-balanced gut microbiome will strengthen the intestinal barrier, which helps to reduce inflammation throughout the body and support the immune system.
• To achieve this, it is important to maintain a healthy and well-balanced lifestyle as we grow older.

Narveen Jandu does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.