Nitroglycerin

• Cosette Pharmaceuticals, Inc. ("Cosette") announced that the U.S. Food and Drug Administration (FDA) has approved the Abbreviated New Drug Applications (ANDA) for the first generic version of RECTIV® (nitroglycerin) ointment, 0.4%, with 180 days Competitive Generic Therapy (CGT) exclusivity.
• Cosette will imminently commence commercial shipments, triggering the 180 days exclusivity.
• This is Cosette’s 24th new product launch and our 3rd CGT approval in the last two years.
• Cosette currently has several products in active development, and several complex product ANDAs pending FDA approval.

• Indeed, many have exotic origins, including the blockbuster drugs Wegovy and Ozempic, which were inspired by the venom of the Gila monster.
• Scientists found that a hormone in the Gila monster’s venom called exendin-4 could be used to treat type 2 diabetes.
• The Gila monster is not the only reptile to inspire groundbreaking drugs.
• Indeed, the venom of the Brazilian pit viper inspired a class of drugs known as ACE inhibitors.

Anticoagulants

• The anticoagulant drugs bivalirudin and desirudin are derived from hirudin.
• If a blood clot jams up an artery, it can cause a stroke or heart attack.
• The drug really took off in 1955 after US president Dwight Eisenhower was successfully treated with it following a heart attack.

Explosive finding

• Nitroglycerin was first discovered in the 19th century, and is derived from glycerol where its explosive properties were initially noted.
• Middle-aged men who worked with explosives – such as those building the rail networks – would sometimes note that their chest pain subsided after handling sticks of dynamite.
• The drug is still used today and is known for the annoying side-effect of triggering explosives scanners at airports.

• Earlier this year, XyloCor reported positive results from the primary study period for the Phase 2 portion EXACT trial at six months.
• “These 12-month data build upon the positive results achieved at the 3- and 6-month marks of the trial.
• The six-month primary study period in the Phase 2 portion of the EXACT trial was followed by a month 12 follow up period.
• "These results further enhance our confidence that we are on the right path for transforming outcomes in cardiovascular disease.”

• The "Ammonia Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2022-2027" report has been added to ResearchAndMarkets.com's offering.
• The global ammonia market reached a value of US$ 71.34 billion in 2021.
• As a result, ammonia is rapidly gaining traction as a purifying agent in water treatment plants and refrigerant in heating, ventilation and air conditioning (HVAC) systems.
• What is the structure of the global ammonia market and who are the key players?