Mammoth

• TARRYTOWN, N.Y., April 25, 2024 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. (NASDAQ:REGN) and Mammoth Biosciences, Inc., today announced a collaboration to research, develop and commercialize in vivo CRISPR-based gene editing therapies for multiple tissues and cell types.
• Mammoth is developing novel ultracompact nucleases and associated gene editing systems, with a variety of editing functionalities at a significantly smaller size than other CRISPR-based systems, including first generation Cas9 nucleases.
• “We believe in the incredible power of gene editing, which we are utilizing in our diverse preclinical and clinical genetic medicines pipeline.
• We look forward to working with Regeneron to enable all-in-one AAV delivery and unlock the true potential of in vivo gene editing,” said Trevor Martin, Ph.D., co-founder and Chief Executive Officer of Mammoth Biosciences.

• In recent years, the global trade in elephant ivory has faced significant restrictions in an effort to protect dwindling elephant populations.
• The sale of mammoth ivory, sourced primarily from long-extinct species, however, remains unregulated.
• But it’s a significant challenge for customs and law enforcement agencies to distinguish between ivory from extinct mammoths and living elephants.
• Now our new study, published in PLOS ONE, presents a major breakthrough – using a well known laser technique to tell mammoth and elephant ivory apart.

This activity not only has commercial implications. It also raises significant ethical and environmental concerns. That’s because it disturbs preserved ecosystems and involves the extraction of resources that have great value to paleontological science.

Laser insights

• We use a non-invasive laser technique known as Raman spectroscopy to identify the origin of a piece of ivory.
• The technique works by directing a laser light onto the ivory sample.
• This released light scatters back with more or less energy than the initial laser light sent to the sample.

Important implications

• This makes it an ideal tool for customs officials who need to make rapid decisions.
• Our study was conducted on a benchtop spectrometer (a device which breaks up light by wavelength) within a laboratory.
• We are working with Worldwide Wildlife Hong Kong and the Foreign and Commonwealth Development Office to develop this technique.

Rebecca Shepherd receives funding from EPSRC and the FCDO.

• DALLAS, March 6, 2024 /PRNewswire/ -- Mammoth Holdings, America's premier express car wash platform, announced the appointment of Bethany Gillam as Chief People Officer, effective immediately.
• "Bethany has a pivotal role in shaping our company culture," said Mammoth CEO David Hoffmann.
• Mammoth Holdings is the first car wash platform formed by industry insiders and has 135 operating locations.
• Oak Hill Advisors provides Mammoth Holdings' debt financing through its direct lending partnership with BMO Capital Markets.

• Alterra Mountain Company has appointed Ron Cohen, President & COO of Mammoth Mountain and June Mountain, and Rob Perlman, President & COO of Steamboat, to the newly created roles of Executive Vice President (EVP), Regional Operations.
• Most importantly, they will focus on identifying and mentoring leaders throughout the Mountain Division.
• We’ve been fortunate to have them lead two of our premier destinations and this new structure will give the rest of the company an opportunity to learn from their experience,” said Mark Brownlie, Chief Operating Officer - Mountain Division, Alterra Mountain Company.
• At Mammoth Mountain and June Mountain, Eric Clark, Chief Operating Officer, Resort Services, will take on the interim duties.