Krainer

Why some RNA drugs work better than others

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星期三, 三月 6, 2024
Infant, Research, Drug development, Krainer, SMA, RNA, Risdiplam, Genome, Patient, SPRING, Pancreatic cancer, Cold Spring Harbor Laboratory, RNA splicing, CSHL, Vaccine

CSHL Associate Professor Justin Kinney, Krainer, and postdoc Yuma Ishigami have figured out why some splicing-based drugs tend to work better than others.

Key Points: 
  • CSHL Associate Professor Justin Kinney, Krainer, and postdoc Yuma Ishigami have figured out why some splicing-based drugs tend to work better than others.
  • To better understand how this drug works, the Kinney and Krainer labs analyzed risdiplam's interactions with RNA.
  • "Our new study provides insights into the action and specificity of splice-modifying drugs," Krainer says.
  • "This should facilitate the development of more effective drugs and drug combinations for a variety of diseases."

PRIMUS AERO chooses PAL-V Liberty to enhance operational excellence

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星期四, 七月 13, 2023
Maintenance, Partnership, Transport, PRIMUS, Multimedia, PAL-V Liberty, Krainer, Aircraft, Airline

RAAMSDONKSVEER, Netherlands, July 13, 2023 /PRNewswire/ -- PRIMUS AERO is investing in the future of transportation with the purchase of a fleet of PAL-V Liberty vehicles, enhancing their operational excellence and minimizing the downtime of clients' aircraft.

Key Points: 
  • RAAMSDONKSVEER, Netherlands, July 13, 2023 /PRNewswire/ -- PRIMUS AERO is investing in the future of transportation with the purchase of a fleet of PAL-V Liberty vehicles, enhancing their operational excellence and minimizing the downtime of clients' aircraft.
  • As Stephan Krainer, CEO and Founder of PRIMUS AERO, explains: "The PAL-V is a time-saving machine for us.
  • PRIMUS AERO aims to utilize the PAL-V Liberty not only for their own operations but also for their aircraft maintenance companies.
  • On top of that PRIMUS AERO's extensive expertise in aircraft maintenance positions them as a key regional partner."

PRIMUS AERO chooses PAL-V Liberty to enhance operational excellence

Retrieved on: 
星期四, 七月 13, 2023
Maintenance, Partnership, Transport, PRIMUS, PAL-V Liberty, Krainer, Aircraft, Airline

RAAMSDONKSVEER, Netherlands, July 13, 2023 /PRNewswire/ -- PRIMUS AERO is investing in the future of transportation with the purchase of a fleet of PAL-V Liberty vehicles, enhancing their operational excellence and minimizing the downtime of clients' aircraft.

Key Points: 
  • RAAMSDONKSVEER, Netherlands, July 13, 2023 /PRNewswire/ -- PRIMUS AERO is investing in the future of transportation with the purchase of a fleet of PAL-V Liberty vehicles, enhancing their operational excellence and minimizing the downtime of clients' aircraft.
  • As Stephan Krainer, CEO and Founder of PRIMUS AERO, explains: "The PAL-V is a time-saving machine for us.
  • PRIMUS AERO aims to utilize the PAL-V Liberty not only for their own operations but also for their aircraft maintenance companies.
  • On top of that PRIMUS AERO's extensive expertise in aircraft maintenance positions them as a key regional partner."

Regimen Equity Partners invests in its ninth platform business, acquiring Thomas Skinner & Son Ltd., Western Canada’s leading distributor of industrial metalworking equipment and machine shop supplies

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星期三, 三月 29, 2023
Mitutoyo, Education, CNC, Krainer, Thomas Skinner, Okuma Corporation, Family, Automation, Management, Regimen, Western Canada

VANCOUVER, British Columbia, March 29, 2023 (GLOBE NEWSWIRE) -- Regimen Equity Partners Inc. (“Regimen”) is pleased to announce its ninth platform investment, acquiring Thomas Skinner & Son Ltd. (“Thomas Skinner” or the “Company”), a generational, privately owned Canadian business with a storied 119-year history.

Key Points: 
  • VANCOUVER, British Columbia, March 29, 2023 (GLOBE NEWSWIRE) -- Regimen Equity Partners Inc. (“Regimen”) is pleased to announce its ninth platform investment, acquiring Thomas Skinner & Son Ltd. (“Thomas Skinner” or the “Company”), a generational, privately owned Canadian business with a storied 119-year history.
  • Thomas Skinner has exclusive and/or preferential distribution rights with many of its suppliers.
  • The legacy and continuity of Thomas Skinner were of upmost importance to us as we embarked upon our succession.
  • We look forward to growing Thomas Skinner, together with the team at Thomas Skinner.

Cutting off liver cancer's nutrient supply chain

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星期四, 二月 3, 2022
Growth, Laboratory, Liver cancer, Neoplasm, Liver, Nobel Prize, Brain, Skin, CSHL, Nutrient, Stony Brook University, Research, Glioblastoma, Cancer, Cold Spring Harbor Laboratory, Cystic fibrosis, Biomedical Research, Cancer research, Genetic code, Student, World Health Organization, Asos, PKM2, Neuroscience, Education, SPRING, World, Protein, Multimedia, RNA, Ionis Pharmaceuticals, Pharmaceutical industry, Dietary supplement, Krainer

ASOs are promising for this type of cancer because after injecting them under the skin, the body would send them directly to the liver.

Key Points: 
  • ASOs are promising for this type of cancer because after injecting them under the skin, the body would send them directly to the liver.
  • The liver cancer would be prevented from growing and spreading to other organs.
  • This strategy also has another benefit, as healthy liver cells do not make the same RNA that ASOs would target in liver cancer cells.
  • Voss says, "Being able to deliver this therapy directly to the liver, without impacting normal liver cells, could provide a more effective, safer option to treat liver cancer in the future."