Cell Reports Publishes Discovery Data Supporting the Importance of Ion Channel, Kv7.2/7.3 as a Therapeutic Target in ALS
Retrieved on:
Tuesday, June 8, 2021
Research, Genetics, Clinical trials, Other Health, Biotechnology, Managed care, Pharmaceutical, Health, Science, Other Science, Neurological disorders, Branches of biology, Neurodegenerative disorders, Efferent neurons, Amyotrophic lateral sclerosis, Motor neuron, Neuron, Kv7.2/7.3 Ion Channel Openers, QRL-101 (QRA-244), QurAlis Corporation, KV7.2/7.3 ION CHANNEL OPENERS, QRL-101 (QRA-244), QURALIS CORPORATION
The publication describes a live-cell screening strategy targeting abnormal electrophysiological properties to reveal targets that modulate the intrinsic hyperexcitability of ALS motor neurons.
Key Points:
- The publication describes a live-cell screening strategy targeting abnormal electrophysiological properties to reveal targets that modulate the intrinsic hyperexcitability of ALS motor neurons.
- This unbiased screen using human ALS motor neurons identified Kv7.2/7.3 as a strongly overrepresented drug target.
- Previous research has identified Kv7.2/7.3 as an ALS drug target and the unbiased nature of this screen further emphasizes the importance of Kv7.2/7.3 in ALS motor neuron dysfunction.
- We are advancing three antisense and small molecule programs addressing sub-forms of ALS that account for the majority of ALS patients.