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Unexpected genetic variant combinations discovered at Agouti Signaling Protein (ASIP) locus in dogs

Retrieved on: 
Wednesday, July 22, 2020

In the study, Atypical genotypes for canine Agouti Signaling Protein suggest novel chromosomal rearrangement , researchers characterize atypical genotypes for one of the proteins responsible for regulating the pigment in a dog's coat, known as Agouti Signaling Protein (ASIP).

Key Points: 
  • In the study, Atypical genotypes for canine Agouti Signaling Protein suggest novel chromosomal rearrangement , researchers characterize atypical genotypes for one of the proteins responsible for regulating the pigment in a dog's coat, known as Agouti Signaling Protein (ASIP).
  • "We can examine these data to uncover rare anomalies like those that our researchers found at the ASIP locus, furthering the field of canine genetic research."
  • "Due to the visual nature of coat colors, this area of dog genetics is a great model to investigate unexpected genetic anomalies.
  • The research team believes that these newly discovered, unexpected genotype combinations have not been identified in purebred dogs prior to this study due to their low frequency.