Cardiac physiology

DGAP-News: 4TEEN4's first-in-class therapeutic antibody Procizumab restores heart function in life-threatening cardiac depression induced by sepsis

Wednesday, September 16, 2020 - 9:01am

The study data (1) from the team lead by Prof. Alexandre Mebazaa have shown that high DPP3 blood values are associated with decreased heart function in a preclinical sepsis model.

Key Points: 
  • The study data (1) from the team lead by Prof. Alexandre Mebazaa have shown that high DPP3 blood values are associated with decreased heart function in a preclinical sepsis model.
  • In this randomized, controlled study, the administration of Procizumab immediately and significantly improved heart function by increasing cardiac output, stroke volume, and left ventricular shortening fraction.
  • By inhibiting DPP3 with our antibody Procizumab, we are able to restore cardiac function in preclinical sepsis models.
  • This inactivation leads to cardiac depression and consequently hemodynamic instability and consequently cardiac depression.

The antihypertensive drugs market will register a CAGR of over 2% by 2023

Tuesday, March 19, 2019 - 10:01pm

Cardioinhibitory drugs depress cardiac function by decreasing heart rate, myocardial contractility, or both, which decreases cardiac output and arterial pressure.

Key Points: 
  • Cardioinhibitory drugs depress cardiac function by decreasing heart rate, myocardial contractility, or both, which decreases cardiac output and arterial pressure.
  • Analysts have predicted that the antihypertensive drugs market will register a CAGR of over 2% by 2023.
  • This, in turn, is expected to aid in the use of available drugs, which will drive the growth of the global antihypertensive drugs market during the forecast period.
  • For the detailed list of factors that will drive and challenge the growth of the antihypertensive drugs market during the 2019-2023, view our report.