Stroke volume

DGAP-News: 4TEEN4's first-in-class therapeutic antibody Procizumab restores heart function in life-threatening cardiac depression induced by sepsis

Wednesday, September 16, 2020 - 9:01am

The study data (1) from the team lead by Prof. Alexandre Mebazaa have shown that high DPP3 blood values are associated with decreased heart function in a preclinical sepsis model.

Key Points: 
  • The study data (1) from the team lead by Prof. Alexandre Mebazaa have shown that high DPP3 blood values are associated with decreased heart function in a preclinical sepsis model.
  • In this randomized, controlled study, the administration of Procizumab immediately and significantly improved heart function by increasing cardiac output, stroke volume, and left ventricular shortening fraction.
  • By inhibiting DPP3 with our antibody Procizumab, we are able to restore cardiac function in preclinical sepsis models.
  • This inactivation leads to cardiac depression and consequently hemodynamic instability and consequently cardiac depression.