ANR

• This agreement reinforces SpikImm's portfolio and expertise for the prophylactic treatment of viral infections in immunocompromised patients.
• BK virus (BKV) infects most individuals early in life and typically remains latent in the body without causing disease.
• However, under immunosuppressive treatment, in particular in transplant patients, BKV can reactivate and replicate in the urinary tract, leading to potentially serious complications.
• SpikImm and SATT Conectus today announced the signature of an exclusive option agreement for the anti-BKV monoclonal antibodies.

• Domain Therapeutics (“Domain” or “the Company”), a clinical-stage global biopharmaceutical company developing innovative drug candidates in immuno-oncology targeting G Protein-Coupled Receptors (GPCRs), today announces it has been awarded a grant as part of the Hospital-University Research in Health (RHU) SPRINT consortium.
• View the full release here: https://www.businesswire.com/news/home/20240125583037/en/
  The SPRINT project aims to revolutionize the management of patients with CTCL and deliver a new cure paradigm as a standard-of-care.
• The grant that we have been awarded by the RHU SPRINT consortium will support the progress of DT-7012, an anti-CCR8 monoclonal antibody which has incredible potential as a best-in-class therapeutic, into the clinic.
• Domain was already awarded a first RHU grant, RHU CONDOR for Sarcoma, in the previous campaign, leveraging another proprietary asset.

• Published in Nature Ecology & Evolution, our new study analyses two skull fragments dating back between 37,000 and 36,000 years to conclude that our ancestors came from Eastern Europe and migrated westwards.
• These individuals are the oldest representatives of Western Europeans to have established themselves permanently in Europe and to have left traces in the genomes of present-day Europeans.

• It is estimated they settled in the region after the ice age that took place from 40,000 to 38,000 years ago.
• Up to this day, researchers believe that the ensuing ecological crisis wiped out both the last Neanderthal populations and the first populations of sapiens humans of the early Upper Palaeolithic.

Homo sapiens from interbreeding

• Both individuals are descendants of distant interbreeding with Neanderthals.
• Our study also showed that the more recent individual bore traces of interbreeding with individuals from the first wave of settlement thought to have been exterminated by the -40,000 year ice age, represented by the Zlatý Kůň individual (-45,000 years).
• We were therefore able to conclude that the first H. sapiens were not completely replaced and some must have survived the ecological crisis.

Links with fossils found in France

• These individuals, close to those from Buran Kaya III, were part of the population associated with the Classical Gravettian period, which produced the female ivory statuettes known as the “Gravettian Venuses” found in France, Germany, Austria and the Czech Republic.
• The famous Venus “Dame de Brassempouy” from the French department of Landes was sculpted at this time.

• The genetic ties indicate that these populations spread from east to west.
• The “Génétique et epigénétique nouvelle ecole” project is supported by the French National Research Agency (ANR), which funds project-based research in France.
• Its mission is to support and promote the development of fundamental and applied research in all disciplines, and to strengthen the dialogue between science and society.

Eva-Maria Geigl has received funding from CNRS, EUR G.E.N.E. (ANR-17-EURE-0013 ; IdEx #ANR-18-IDEX-0001 l'Université de Paris ; Programme d'Investissements d'Avenir) Thierry Grange has received funding from the Fondation pour la Recherche Médicale (DGE20111123014), Région Ile-de-France (11015901), CNRS, EUR G.E.N.E. (ANR-17-EURE-0013 ; IdEx #ANR-18-IDEX-0001 l'Université de Paris ; Programme d'Investissements d'Avenir).

• DENVER, Sept. 14, 2023 (GLOBE NEWSWIRE) -- Intermap Technologies (TSX: IMP; OTCQB: ITMSF) (“Intermap” or the “Company”), a global leader in 3D geospatial products and intelligence solutions, today announced that its U.S. insurance solution, InsitePro®, empowered customers to report excellent underwriting results after Tropical Storm Hilary.
• Major storm events are the testing ground for underwriting solutions, and like with Ian and Harvey, InsitePro delivered excellent results through Tropical Storm Hilary, the first such storm to hit California in over 80 years.
• These results demonstrate the importance of incorporating advances in technology and staying up to date with climate change.
• Many U.S. clients are seeing very few insurance claims from recent storms as a result of using InsitePro for risk selection and underwriting.