Bacillota

Seed Health Appoints Microbiome Pioneer Zain Kassam, M.D., M.P.H., as Chief Medical Officer

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水曜日, 4月 24, 2024
Western University, Harvard University, Nature Biotechnology, Public health, Chairperson, Abstract, Health, McMaster University, OpenBiome, FMT, Janssen, IPO, Therapy, Science, Ecology, Alumni, Internal medicine, Bacillota, Longevity, Growth, MIT, Medical device

BOSTON, April 24, 2024 /PRNewswire/ -- Seed Health, a microbiome science company, today announced the appointment of Zain Kassam, M.D., M.P.H., as Chief Medical Officer. An award-winning physician-scientist, Dr. Kassam has played a pivotal role in the advancement of microbiome science for over a decade. His extensive body of work includes over 200 peer-reviewed publications and abstracts, including in The New England Journal of Medicine, Nature Biotechnology, and Gastroenterology, and co-authoring international clinical practice guidelines. He has championed more than 30 Phase I-III clinical trials with top-tier academic institutions across multiple therapeutic areas. As Chief Medical Officer, Dr. Kassam will collaborate with Chief Scientific Officer, Dirk Gevers, Ph.D., to oversee Seed Health's R&D portfolio. He will expand the company's gut microbiome program and guide upcoming launches in the vaginal and skin microbiome sectors, as well as in brain health, metabolic health, and longevity.

Key Points: 
  • Dr. Kassam will lead Seed Health's clinical research and medical affairs, driving the
    BOSTON, April 24, 2024 /PRNewswire/ -- Seed Health , a microbiome science company, today announced the appointment of Zain Kassam, M.D., M.P.H., as Chief Medical Officer.
  • As Chief Medical Officer, Dr. Kassam will collaborate with Chief Scientific Officer, Dirk Gevers, Ph.D., to oversee Seed Health's R&D portfolio.
  • He will expand the company's gut microbiome program and guide upcoming launches in the vaginal and skin microbiome sectors, as well as in brain health, metabolic health, and longevity.
  • Before joining Seed Health, Dr. Kassam co-founded and was Chief Medical Officer at two foundational microbiome therapeutics companies, OpenBiome and Finch Therapeutics.

Gut bacteria and the immune system: How aging changes the microbiome and can lead to ‘inflammaging’

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水曜日, 4月 3, 2024
Research, Inflammation, Inflammaging, Health, Red meat, Vitamin, Bacillota, Nutrient, Archaea, Cell, Environment, Disease, Infection, Homeostasis, Probiotic, Risk, Dysbiosis, Gastrointestinal tract, Extrapyramidal system, Tissue, Actinomycetota, Fungus, Bacteria, Virus, University, Life, Pseudomonadota, Type 2 diabetes, Diet, Nutritional science, Mucus, Immune system, Cellular senescence, Family, Stomach, Antigen, Type 2, Vaccine

Research has shown that changes to the composition and diversity of the microorganisms in the gut may explain these differences in immune system aging.

Key Points: 
  • Research has shown that changes to the composition and diversity of the microorganisms in the gut may explain these differences in immune system aging.
  • However, as the composition of our gut microbiome changes with age, a low level of inflammation can become constant throughout the body.
  • Let’s take a closer look at the gut microbiome and how it changes with age.

Gut microbiome imbalances in older adults

  • In fact, compared to other parts of the body, the gut microbiome has the largest number of bacteria.
  • In a healthy gut microbiome, there are four dominant families (or phyla) of microorganisms, including Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria.
  • Firmicutes and Bacteroidetes make up around 80 to 90 per cent of the gut microbiota in the digestive tract.
  • Over time, the shortage of beneficial bacteria such as Firmicutes in older adults starts to compromise the integrity of their intestinal barrier, causing it to become leaky.

How inflammaging works

  • Inflammaging creates an environment that is prone to inflammation, which is caused and maintained by several factors.
  • These can include microorganism imbalances in the intestines (microbial dysbiosis), psychological stress, physical inactivity, poor nutrition and chronic infections.

Maintaining a healthy balance of gut microbiota

  • More specifically, probiotics help improve the function of the intestinal barrier and regulate immune responses by modifying the composition of the gut microbiome.
  • It is clear that the immune system has an intricate relationship with the gut microbiome.
  • A healthy and well-balanced gut microbiome will strengthen the intestinal barrier, which helps to reduce inflammation throughout the body and support the immune system.
  • To achieve this, it is important to maintain a healthy and well-balanced lifestyle as we grow older.


Narveen Jandu does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Newly Engineered Versions of Bacterial Enzyme Reveal How Antibiotics Could Be More Potent

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水曜日, 8月 30, 2023
Pseudomonadota, Bacillota, DNA, Nature, Multiplex, Infection, NYU, New York University Grossman School of Medicine, National Institutes of Health, Howard Hughes Medical Institute, Escherichia coli, Research, Cell, RNA, Doctor of Philosophy, Dicarboxylic acid, MAGE, NYU Langone Health, Protein, Pyrimidine, MD, Growth, Bacteria, Gene, RNAP, Medicine, Antibiotics, Vaccine, Biochemistry

NEW YORK, Aug. 30, 2023 /PRNewswire/ -- Modern medicine depends on antibiotics to treat infections by disabling targets inside bacterial cells.

Key Points: 
  • NEW YORK, Aug. 30, 2023 /PRNewswire/ -- Modern medicine depends on antibiotics to treat infections by disabling targets inside bacterial cells.
  • Once inside these cells, antibiotics bind to certain sites on specific enzyme targets to stop bacterial growth.
  • Researchers have for decades studied resistant mutants in hopes that related mechanisms would guide the design of new treatments to overcome resistance.
  • Not only does the antibiotic prevent these mutants from growing, it nearly obliterates the mutant bacterial populations.

Ulcerative Colitis Treatment Market to Grow Exponentially by 2029- Brandessence Market Research

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木曜日, 5月 18, 2023
MSD, Janus, Insurance, Prevalence, Interleukin 23, Abbott Laboratories, Enzyme, Diarrhea, Colon, Protein, Acquisition, Patient, Integrin, Eli Lilly and Company, Etrolizumab, Cell adhesion, Filgotinib, GSK plc, Pancolitis, Upadacitinib, USD, FMT, HIV disease progression rates, Allergan, Safety, GSK, Risankizumab, Mirikizumab, Takeda Pharmaceutical Company, Roche, MEA, Biomarker, Abdominal pain, Ulcerative colitis, UC, AbbVie, Cancer, Antibody, Bacillota, Johnson & Johnson, Sphingosine, Colitis, Module (mathematics), IL-12, TNF, JAK, Cramp, Pfizer, Inflammation, AstraZeneca, Eli Lilly, Ozanimod, Novartis, Cytokine, Health, Pharmaceutical industry, Dietary supplement, Vaccine, Health insurance, Bayer

The Global Ulcerative Colitis Treatment Market report curated by Brandessence Market Research provides a detailed overview of the market, including its size, growth rate, and key drivers.

Key Points: 
  • The Global Ulcerative Colitis Treatment Market report curated by Brandessence Market Research provides a detailed overview of the market, including its size, growth rate, and key drivers.
  • It examines various treatment options available for ulcerative colitis, including medications, surgery, and other therapies.
  • High Cost of Treatment: One of the major challenges in the ulcerative colitis treatment market is the high cost associated with the available treatment options.
  • FMT is being explored as a potential treatment option for ulcerative colitis, with ongoing clinical trials assessing its safety and efficacy.

Ulcerative Colitis Treatment Market to Grow Exponentially by 2029- Brandessence Market Research

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木曜日, 5月 18, 2023
MSD, Janus, Insurance, Prevalence, Interleukin 23, Abbott Laboratories, Enzyme, Diarrhea, Colon, Protein, Acquisition, Patient, Integrin, Eli Lilly and Company, Etrolizumab, Cell adhesion, Filgotinib, GSK plc, Pancolitis, Upadacitinib, USD, FMT, HIV disease progression rates, Allergan, Safety, GSK, Risankizumab, Mirikizumab, Takeda Pharmaceutical Company, Roche, MEA, Biomarker, Abdominal pain, Ulcerative colitis, UC, AbbVie, Cancer, Antibody, Bacillota, Johnson & Johnson, Sphingosine, Colitis, Module (mathematics), IL-12, TNF, JAK, Cramp, Pfizer, Inflammation, AstraZeneca, Eli Lilly, Ozanimod, Novartis, Cytokine, Health, Pharmaceutical industry, Dietary supplement, Vaccine, Health insurance, Bayer

The Global Ulcerative Colitis Treatment Market report curated by Brandessence Market Research provides a detailed overview of the market, including its size, growth rate, and key drivers.

Key Points: 
  • The Global Ulcerative Colitis Treatment Market report curated by Brandessence Market Research provides a detailed overview of the market, including its size, growth rate, and key drivers.
  • It examines various treatment options available for ulcerative colitis, including medications, surgery, and other therapies.
  • High Cost of Treatment: One of the major challenges in the ulcerative colitis treatment market is the high cost associated with the available treatment options.
  • FMT is being explored as a potential treatment option for ulcerative colitis, with ongoing clinical trials assessing its safety and efficacy.

Noster Microbiome research: Fibrous fuel: Prebiotic fibers can keep the body's metabolism in check to improve gut-environment and suppress obesity

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木曜日, 3月 23, 2023
Tokyo University of Agriculture and Technology, Extrapyramidal system, Tissue, University of Tokyo, Cellulose, Obesity, Diet, SCFA, Diabetes, Probiotic, Digestion, Fed, Nutritional science, Blood, Metabolism, Leuconostoc mesenteroides, Kyoto University, Yogurt, Host, HFD, Mouse, EPS, Bacteria, Health, Bacillota, System, Prebiotic (nutrition), Human, Gum arabic, Dietary supplement, Leuconostoc, Verrucomicrobiota, Bacteroides, Bacteroidota

Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.

Key Points: 
  • Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.
  • A complementary food group known as prebiotics (mainly fibrous foods) serve as fuel for these bacteria to thrive.
  • Lactic acid bacteria, such as Leuconostoc mesenteroides (L. mesenteroides), are used in the fermentation process of fermented foods such as kimchi, sauerkraut, and pickles.
  • The researchers thus focused their study on the potential role of LmEPS as a prebiotic fiber.

Noster Microbiome research: Fibrous fuel: Prebiotic fibers can keep the body's metabolism in check to improve gut-environment and suppress obesity

Retrieved on: 
木曜日, 3月 23, 2023
Tokyo University of Agriculture and Technology, Extrapyramidal system, Tissue, University of Tokyo, Cellulose, Obesity, Diet, SCFA, Diabetes, Probiotic, Digestion, Fed, Nutritional science, Blood, Metabolism, Leuconostoc mesenteroides, Kyoto University, Yogurt, Host, HFD, Mouse, EPS, Bacteria, Health, Bacillota, System, Prebiotic (nutrition), Human, Gum arabic, Dietary supplement, Leuconostoc, Verrucomicrobiota, Bacteroides, Bacteroidota

Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.

Key Points: 
  • Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.
  • A complementary food group known as prebiotics (mainly fibrous foods) serve as fuel for these bacteria to thrive.
  • Lactic acid bacteria, such as Leuconostoc mesenteroides (L. mesenteroides), are used in the fermentation process of fermented foods such as kimchi, sauerkraut, and pickles.
  • The researchers thus focused their study on the potential role of LmEPS as a prebiotic fiber.