Arcobacter

Kanazawa University research: Sodium channel investigation

Retrieved on: 
Mercoledì, Dicembre 20, 2023

KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.

Key Points: 
  • KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.
  • An important open question is whether the voltage sensor domains dissociate from the pore domains when the channel closes.
  • One is the sodium channel of a particular bacterium (Arcobacter butzleri), the other two are mutants thereof.
  • In recent years, researchers at Kanazawa University have further developed HS-AFM so that it can be applied for studying biochemical molecules and biomolecular processes in real-time.

Kanazawa University research: Sodium channel investigation

Retrieved on: 
Mercoledì, Dicembre 20, 2023

KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.

Key Points: 
  • KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.
  • An important open question is whether the voltage sensor domains dissociate from the pore domains when the channel closes.
  • One is the sodium channel of a particular bacterium (Arcobacter butzleri), the other two are mutants thereof.
  • In recent years, researchers at Kanazawa University have further developed HS-AFM so that it can be applied for studying biochemical molecules and biomolecular processes in real-time.

Kanazawa University research: Ion channel block unraveled

Retrieved on: 
Martedì, Agosto 1, 2023

KANAZAWA, Japan, Aug. 1, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes.

Key Points: 
  • KANAZAWA, Japan, Aug. 1, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes.
  • Tetrameric ion channels are prone to 'divalent cation block', the blocking of the channel by ions like calcium (Ca2+).
  • Now, Takashi Sumikama from Kanazawa University in collaboration with Katsumasa Irie from Wakayama Medical University and colleagues has discovered the mechanism behind divalent cation block in NavAb, a well-known tetrameric sodium (Na) channel.
  • The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel, Nature Communications 14, 4236 (2023).

Kanazawa University research: Ion channel block unraveled

Retrieved on: 
Martedì, Agosto 1, 2023

KANAZAWA, Japan, Aug. 1, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes.

Key Points: 
  • KANAZAWA, Japan, Aug. 1, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes.
  • Tetrameric ion channels are prone to 'divalent cation block', the blocking of the channel by ions like calcium (Ca2+).
  • Now, Takashi Sumikama from Kanazawa University in collaboration with Katsumasa Irie from Wakayama Medical University and colleagues has discovered the mechanism behind divalent cation block in NavAb, a well-known tetrameric sodium (Na) channel.
  • The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel, Nature Communications 14, 4236 (2023).