Kanazawa University research: Ion channel block unraveled
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Martedì, Agosto 1, 2023
KANAZAWA, Japan, Aug. 1, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes.
Key Points:
- KANAZAWA, Japan, Aug. 1, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes.
- Tetrameric ion channels are prone to 'divalent cation block', the blocking of the channel by ions like calcium (Ca2+).
- Now, Takashi Sumikama from Kanazawa University in collaboration with Katsumasa Irie from Wakayama Medical University and colleagues has discovered the mechanism behind divalent cation block in NavAb, a well-known tetrameric sodium (Na) channel.
- The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel, Nature Communications 14, 4236 (2023).