Alkaloid | Jotup

Industrial Sonomechanics Publishes Groundbreaking Pharmacokinetic Study of Two Delta-8 THC Nanoemulsions

Retrieved on:

Dienstag, April 9, 2024

Cannabinoid, ISM, Tablet, Absorption, MCT, Drink, Alkaloid, Nano, THC, Terpene, Airline

MIAMI, April 9, 2024 /PRNewswire/ -- Industrial Sonomechanics® ( ISM ) has recently completed a groundbreaking pre-clinical pharmacokinetic study, comparing two orally administered Delta-8 THC nanoemulsions (liquid and powdered) with a Delta-8 THC solution in MCT oil.

Key Points:

MIAMI, April 9, 2024 /PRNewswire/ -- Industrial Sonomechanics® ( ISM ) has recently completed a groundbreaking pre-clinical pharmacokinetic study, comparing two orally administered Delta-8 THC nanoemulsions (liquid and powdered) with a Delta-8 THC solution in MCT oil.
This marks the industry's first pre-clinical study of Delta-8 THC nanoemulsions.
Translucent liquid and powdered Delta-8 THC nanoemulsions displayed similar pharmacokinetic profiles.
Delta-8 THC nanoemulsions made with ISM's technology provide an almost immediate onset time and considerably greater absorption within time windows of interest.

Draft guideline on good agricultural and collection practice (GACP) for starting materials of herbal origin - Revision 1

Retrieved on:

Donnerstag, April 18, 2024

Reproduction, SCOPE, Eating, Pesticide, Convention, Change control, Confusion, Alkaloid, Climate, Fungus, Directive (European Union), Ethylene oxide, Wind, Wood, Glass, European Medicines Agency, HMPS, QDG, Hygiene, Water, Marketing, Fertilizer, Legislation, Manure, Distillation, Risk, Education, Committee, Compost, Draft, Policy, Person, EMA, Seed, Polycyclic aromatic hydrocarbon, Collection, Freezing, GMP, Risk assessment, GACP, Sunlight, Fermentation, Personal protective equipment, Animal, Herbal, Herbicide, Weather, INTRODUCTION, Documentation, Regeneration, Decontamination, EudraLex, Disease, International trade, European Pharmacopoeia, Part, Livestock, Public, Inhalation, Knowledge, Seedling, Factorization of polynomials, Record, Plant, Skin, API, Irrigation, Part Two, Soil, Directive, Pharmacopoeia, Codex, Guideline, Temperature, Attention, Hydrocarbon, Pyrrolizidine alkaloid, Polychlorinated biphenyl, Growth, Rotation, Incineration, Environment, Humidity, Smell, Ventilation, Light, Bird, Mineral, Fumigation, Pyrrolizidine, SOP, Housing, Smoking, Atmosphere, Postharvest, Rain, Liver, QWP, Medicinal plants

REFERENCES ....................................................................................................................................... 14

Key Points:

REFERENCES ....................................................................................................................................... 14
29

Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 3/14

30

EXECUTIVE SUMMARY

31
32
33
34
35
36

This guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin

37

1.
Due to the inherent
complexity of medicinal plants and herbal substances the quality of these starting materials requires an
adequate quality assurance system for the collection and/or cultivation, harvest, and primary
processing.
(either outdoor, indoor or in greenhouses) should be carefully considered, since each of the mentioned
types could have several problems and advantages.
The used cultivation method may be dependent on
the final application of the herbal medicinal product.
primary processing of herbal substances that are used for the preparation of herbal medicinal products.
medicinal plants and herbal substances, ensuring that they are handled appropriately throughout all
stages of cultivation, collection, processing and storage.
their preparations are exposed to a large number of environmental contaminants of both biotic and
abiotic origin.
to existing wildlife habitats and must adhere to CITES (Convention on International Trade in
Endangered species of Wild Fauna and Flora).
https://health.ec.europa.eu/document/download/bd537ccf-9271-4230-bca1-2d...
4 https://health.ec.europa.eu/document/download/fd318dd6-2404-4e67-82b0232...
3
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 5/14

104

4.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 6/14

147
148
149

8.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 7/14

185

7.
Where possible, stable varieties and cultivars naturally
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 8/14

227
228

resistant or tolerant to disease should preferably be used.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 9/14

268
269
270
271
272
273

The application should be carried out only by qualified staff using approved equipment.
The following should be noted:
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 10/14

309
310

?

311
312
313

?

314
315
316
317

?

318
319
320

?

321
322

?

323
324
325

?

326
327
328

?

Damaged plants or plant parts need to be excluded or limited in accordance with a specific
pharmacopoeia monograph, where relevant.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 11/14

347
348

directly to the sun (except in cases where there is a specific need) and must be protected from
rainfall, insect infestation, etc.
The label must be clear, permanently fixed and made from
6

Reflection paper on the use of fumigants (EMEA/HMPC/125562/2006)

Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 12/14

386
387

non-toxic material.
Certain exudates that have not been subjected to a specific treatment are
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 13/14

425
426
427

also considered to be herbal substances.
European Pharmacopoeia General Monograph ?HERBAL DRUGS? 07/2017:1433
Are obtained by subjecting herbal substances to treatments such as
extraction, distillation, expression, fractionation, purification, concentration
or fermentation.

Draft guideline on good agricultural and collection practice (GACP) for starting materials of herbal origin - Revision 1

Retrieved on:

Donnerstag, April 18, 2024

REFERENCES ....................................................................................................................................... 14

Key Points:

REFERENCES ....................................................................................................................................... 14
29

Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 3/14

30

EXECUTIVE SUMMARY

31
32
33
34
35
36

This guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin

37

1.
Due to the inherent
complexity of medicinal plants and herbal substances the quality of these starting materials requires an
adequate quality assurance system for the collection and/or cultivation, harvest, and primary
processing.
(either outdoor, indoor or in greenhouses) should be carefully considered, since each of the mentioned
types could have several problems and advantages.
The used cultivation method may be dependent on
the final application of the herbal medicinal product.
primary processing of herbal substances that are used for the preparation of herbal medicinal products.
medicinal plants and herbal substances, ensuring that they are handled appropriately throughout all
stages of cultivation, collection, processing and storage.
their preparations are exposed to a large number of environmental contaminants of both biotic and
abiotic origin.
to existing wildlife habitats and must adhere to CITES (Convention on International Trade in
Endangered species of Wild Fauna and Flora).
https://health.ec.europa.eu/document/download/bd537ccf-9271-4230-bca1-2d...
4 https://health.ec.europa.eu/document/download/fd318dd6-2404-4e67-82b0232...
3
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 5/14

104

4.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 6/14

147
148
149

8.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 7/14

185

7.
Where possible, stable varieties and cultivars naturally
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 8/14

227
228

resistant or tolerant to disease should preferably be used.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 9/14

268
269
270
271
272
273

The application should be carried out only by qualified staff using approved equipment.
The following should be noted:
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 10/14

309
310

?

311
312
313

?

314
315
316
317

?

318
319
320

?

321
322

?

323
324
325

?

326
327
328

?

Damaged plants or plant parts need to be excluded or limited in accordance with a specific
pharmacopoeia monograph, where relevant.
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005
Page 11/14

347
348

directly to the sun (except in cases where there is a specific need) and must be protected from
rainfall, insect infestation, etc.
The label must be clear, permanently fixed and made from
6

Reflection paper on the use of fumigants (EMEA/HMPC/125562/2006)

Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 12/14

386
387

non-toxic material.
Certain exudates that have not been subjected to a specific treatment are
Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
EMA/HMPC/246816/2005

Page 13/14

425
426
427

also considered to be herbal substances.
European Pharmacopoeia General Monograph ?HERBAL DRUGS? 07/2017:1433
Are obtained by subjecting herbal substances to treatments such as
extraction, distillation, expression, fractionation, purification, concentration
or fermentation.

Herbal medicinal product: Symphyti radixArray, F: Assessment finalised

Retrieved on:

Dienstag, März 12, 2024

Key, Liver, Committee, Monograph, Inflammation, Swelling, Skin, Date, Risk, Mouth, Patient, Medicine, Herbal, Herbal medicine, Alkaloid, Medicinal plants

Overview

Key Points:

Overview
This is a summary of the scientific conclusions reached by the Committee on Herbal Medicinal Products (HMPC) on the medicinal uses of comfrey root.
The HMPC conclusions are taken into account by EU Member States when evaluating applications for the licensing of herbal medicines containing comfrey root.
Herbal medicines containing this comfrey root preparation are available in semi-solid forms (such as creams or ointments) to be applied to the skin.
Comfrey root - Summary for the public
Key facts
- Latin name
- Symphyti radix
- English common name
- Comfrey Root
- Botanical name
Symphytum officinale L.
- Therapeutic area
- Pain and inflammation
- Status
- F: Assessment finalised
- Date added to the inventory
- Date added to priority list
- Outcome of European assessment
- European Union herbal monograph

Branded Legacy, Inc. Innovates with Launch of the First 100% Clear Kava-Based Vaping Product on the Market

Retrieved on:

Dienstag, Februar 6, 2024

Anxiety, Research, Migraine, Terpene, Therapy, Sleep, Pain, Safety, Headache, Cannabinoid, Alkaloid, Pain management, Health, Legacy, Teahouse

MELBOURNE, Fla., Feb. 6, 2024 /PRNewswire/ -- Branded Legacy, Inc. (OTC.PK: BLEG), a prominent Biotech company, proudly announces a major breakthrough in research and development efforts, leading the pack on new procedures for the extraction and refinement of kavalactones. In addition, The Alcannabist LLC, a wholly owned subsidiary of Branded Legacy , announced the official release of its new line of groundbreaking products designed to address diverse health and wellness needs.

Key Points:

We were able to make a high purity extract that was completely translucent and very flavorful on the first day.
When we presented our extract to our kava suppliers, they asked to move forward immediately with a white label contract.
The Alcannabist's new products, which include: VapeRx Anti Anxiety, ElixRx Migraine/Headache Support, and Mood Mix Capsules, are now officially on the market.
The other three, ElixRx Plus Kava Anti Anxiety, ElixRx Plus Kava Sleep, and ElixRx Plus Kava Pain Management, will be included in their ElixRx line.

The Mind-bending Mushroom: Expanding Consciousness and Cultural Acceptance of Psychedelic Alkaloids as Medicinal Tools, Upcoming Webinar Hosted by Xtalks

Retrieved on:

Donnerstag, November 2, 2023

TORONTO, Nov. 2, 2023 /PRNewswire-PRWeb/ -- Mushrooms have been used in medicinal and spiritual practices by Indigenous cultures around the world for several millennia. Because of renewed interest in entheogenic plant molecules as therapeutics, there is a large body of research building around psychedelic alkaloids found in the fungi kingdom. The three most studied genera include Psilocybe, Amanita and Claviceps, each with its own infamous history.

Key Points:

In this free webinar, learn about the history, chemistry and pharmacology behind some of the most notorious alkaloids in human history.
The featured speaker will discuss the pharmacology and chemistry of tryptamines, beta-carbolines, isoxazoles and ergolines classes of alkaloids and their use in psychedelic medicine.
TORONTO, Nov. 2, 2023 /PRNewswire-PRWeb/ -- Mushrooms have been used in medicinal and spiritual practices by Indigenous cultures around the world for several millennia.
Join this webinar and learn about the history, chemistry and pharmacology behind some of the most notorious alkaloids in human history.

Is this the protein plant of the future? New study finds 'sweetness gene' that makes lupins tastier

Retrieved on:

Freitag, August 4, 2023

Lupins are very high in protein and fibre, low in carbs, have a low glycaemic index, and they’re easy to grow in a variety of climates.

Key Points:

Lupins are very high in protein and fibre, low in carbs, have a low glycaemic index, and they’re easy to grow in a variety of climates.
The search for sweetness
Around 100 years ago, plant breeders in Germany found natural mutations that produced “sweet lupins” with far lower levels of bitter alkaloids.
Over the past 50 years or so, lupins have become more common as food for farm animals.
Read more: Plant-based patties, lab-grown meat and insects: how the protein industry is innovating to meet demand

Branded Legacy, Inc. Unveils Strategic Transformation in Investor Teleconference

Retrieved on:

Donnerstag, Juli 27, 2023

Marketing, Alkaloid, Research, BLEG, Patient, Mycology, Growth, FDA, Management, Pharmaceutical industry, Music

MELBOURNE, Fla., July 27, 2023 /PRNewswire/ -- Branded Legacy, Inc. (OTC-PINK: BLEG), a holding company specializing in growth through acquisitions with a focus on the biotech industry, announced today …

Key Points:

MELBOURNE, Fla., July 27, 2023 /PRNewswire/ -- Branded Legacy, Inc. (OTC-PINK: BLEG), a holding company specializing in growth through acquisitions with a focus on the biotech industry, announced today …
We have conducted an investor teleconference to announce our significant strategic transformation and bold expansion plans within the biotechnology sector.
The focus on maximizing long-term value by carrying only assets aligned with the company's mission was emphasized.
Branded Legacy's investor teleconference marked a pivotal moment in the company's transformation and expansion into the biotechnology sector.
For further information and updates on Branded Legacy's progress, please visit their website at brandedlegacy.com or contact the company at [email protected] .

Montréaler Wins $10,000 Top Prize in Scrabble Championship

Retrieved on:

Donnerstag, Juli 20, 2023

WESPA, International, Scrabble Players Championship, Scrabble, Alkaloid, ME, Westgate Hotel, Sokol, Mattel Inc v 3894207 Canada Inc, NASPA, Casino, Video game, Hasbro, Mattel

LAS VEGAS, July 19, 2023 /PRNewswire/ -- Joshua Sokol, a 29-year-old Scrabble influencer from Montréal, Canada, has just won $10,000 playing in NASPA's annual Scrabble Players Championship, held this year at the Westgate Hotel in Las Vegas.

Key Points:

LAS VEGAS, July 19, 2023 /PRNewswire/ -- Joshua Sokol, a 29-year-old Scrabble influencer from Montréal, Canada, has just won $10,000 playing in NASPA's annual Scrabble Players Championship, held this year at the Westgate Hotel in Las Vegas.
Montréaler defeats Mainer in Vegas to win $10K share of $54K prize pool in NASPA's annual Scrabble Players Championship.
Competition resumes for 200 players from 32 countries on Friday with a one-day qualification event for the WESPA (World) Championship, which runs July 21-26, also featuring a $10,000 top prize.
Since 2009, NASPA has been the governing body for over 19,000 competitive Scrabble players in the United States and Canada.

Drugs and religion have been a potent combination for millennia, from cannabis at ancient funerary sites to psychedelic retreats today

Retrieved on:

Freitag, Juli 14, 2023

Well-known figures like quarterback Aaron Rodgers, singer Miley Cyrus and boxer Mike Tyson testify to their transformative impact.

Key Points:

Well-known figures like quarterback Aaron Rodgers, singer Miley Cyrus and boxer Mike Tyson testify to their transformative impact.
Less visible consumers are “microdosing” or signing up for retreats with shamanic guides in this rapidly expanding subculture.

Drugged animals?

Signs of stoner life in the animal kingdom go way beyond cats and their catnip.
Among the more celebrated examples of this phenomenon are Siberian reindeer, which partake in the consumption of the fly agaric mushroom, a hallucogenic.
Biology professor Oné R. Pagán makes a similar argument in his 2021 book “Drunk Flies and Stoned Dolphins.”

Drugged ancestors?

In fact, the archaeological record seems quite overwhelming in linking psychoactive substances in nature to ancient religious rituals.
Researchers chemically analyzed human hair samples that had been put in tubes made of wood or antler and placed near the dead.
Switching continents, a funerary space in western China also points to deep-rooted connections among drugs, altered states and ritual life.

Sacred drugs?

What led our prehistoric ancestors to these powerful plants and fungi, and why did they use them over and over?
On the other hand, the needs and desires of people living today have been shaped by modern societies.
In research about prehistoric societies, the term “shaman” is a catch-all designation for individuals whose roles included religious leadership, healing and spirit communication, among others.

Drugged today

What do the animalistic and ancient roots of humans’ interaction with drugs tell us about this contemporary landscape?
The use of drugs in these experiences was not universal, but it was not uncommon either – especially in religious life.
Here and now, these types of uses for psychedelics have often been rebranded as clinical science, not spirituality.