UCSF Benioff Children's Hospital

Genetic ancestry provides important context for understanding global diversity in childhood leukemia

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星期四, 一月 27, 2022
St. Jude Children's Research Hospital, Biology, UCSF Benioff Children's Hospital, Genetic variation, ALSAC, JAMA Oncology, Cancer, CRLF2, Patient, Philadelphia, DUX4, University, KK Women's and Children's Hospital, National, Andijan State Medical Institute, University of California, National Cancer Institute, Child, T-ALL, Acute lymphoblastic leukemia, Social media, Department, Leukemia, Research, ALL, Multimedia, NCI-designated Cancer Center, Survival, Children's Hospital of Philadelphia, Prognosis, Risk, Incidence, Yang, NUDT15, Toxicity, Awareness, Hospital, University Malaya Medical Centre, Medicine, Vaccine, Pharmacy, Native, Jude the Apostle

The scientists assembled an international cohort to determine how genetic ancestry affects leukemia biology and outcomes for modern therapy.

Key Points: 
  • The scientists assembled an international cohort to determine how genetic ancestry affects leukemia biology and outcomes for modern therapy.
  • Racial disparities exist in both the incidence and treatment outcomes for childhood ALL, and there is limited data on the genetic basis for such disparities.
  • The researchers used a genomic technique called RNA-sequencing to comprehensively characterize ALL molecular subtype and genetic ancestry of each child.
  • These NUDT15 variants are rarely found in children with European ancestry, highlighting how important findings can be missed if studies do not include diversity in genetic ancestry.

Greenfield Twin Born at Midnight at Natividad is Monterey County’s First Birth of 2022

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星期日, 一月 2, 2022
Central Coast, Hospital, UCSF, Family, Trauma, Natividad Medical Center, UCSF Benioff Children's Hospital, GLOBE, Trauma center, Â, TWINS, Faculty, Patient

Aylin Yolanda Trujillo entered the world exactly at midnight on Saturday, Jan. 1, making her the first baby born at Natividad Medical Center and in Monterey County in 2022.

Key Points: 
  • Aylin Yolanda Trujillo entered the world exactly at midnight on Saturday, Jan. 1, making her the first baby born at Natividad Medical Center and in Monterey County in 2022.
  • Aylin weighed in at 5 pounds, 14 ounces, while big brother Alfredo weighed 6 pounds, 1 ounce.
  • There are about 120,000 twin births in the U.S. every year, making up just over 3% of all births.
  • Through its UCSF-affiliated Natividad Family Medicine Residency, Natividad is the only teaching hospital on the Central Coast.

Cyclo Therapeutics Appoints Caroline Hastings, M.D. as Global Principal Investigator for Ongoing TransportNPC™ Study Evaluating Trappsol® Cyclo™ for the Treatment of Niemann-Pick Disease

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星期四, 十二月 9, 2021
Biotechnology, Other Health, Health, Pharmaceutical, Oncology, Mental Health, Other Science, Research, Genetics, Science, Clinical Trials, Central nervous system, Disease, American Society of Pediatric Hematology/Oncology, Niemann–Pick disease, PIP, Therapy, Trial of the century, CYTH, Acute lymphoblastic leukemia, Nasdaq, EMA, Physician, Global, Knowledge, Form 10-K, Hastings, Patient, SOC, Priority review, Biomarker, Organization, Children's Hospital Oakland, Protocol, Expanded access, UCSF Benioff Children's Hospital, Risk, U.S. Securities and Exchange Commission, Cyclodextrin, Company, Spinal cord, Hospital, Security (finance), NPC1, Glycogen storage disease, Neoplasm, Neuro, NPC, Safety, Brain, Pediatrics, Science, MD, Education, CNS, Standard of care, Adult, Program, Doctor of Philosophy, Human, Pharmaceutical industry, Medical device

as Global Principal Investigator (PI) for its pivotal Phase 3 study ( TransportNPC ), which commenced in June 2021, evaluating Trappsol Cyclo, the Companys proprietary formulation of hydroxypropyl beta cyclodextrin, for the treatment of Niemann-Pick Disease Type C1 (NPC), a rare, progressive and fatal genetic disorder.

Key Points: 
  • as Global Principal Investigator (PI) for its pivotal Phase 3 study ( TransportNPC ), which commenced in June 2021, evaluating Trappsol Cyclo, the Companys proprietary formulation of hydroxypropyl beta cyclodextrin, for the treatment of Niemann-Pick Disease Type C1 (NPC), a rare, progressive and fatal genetic disorder.
  • Dr. Hastings is a key voice and advocate within the NPC community and has dedicated her clinical career to serving this community.
  • We are honored to expand her role as our Global Principal Investigator for our pivotal study and help drive this important program forward toward potential approval.
  • I am dedicated to advancing TransportNPC towards completion and Trappsol Cyclo towards potential approval for the treatment of NPC, added Dr. Hastings, Global Principal Investigator for the TransportNPC trial and member of Cyclo Therapeutics Scientific Advisory Board.

Robin Washington joins StockX Board of Directors as Audit Committee Chair

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星期三, 十二月 8, 2021
Santa Clara University, Air Jordan, Robin, StockX, Electronics, Honeywell, Audit committee, Technology, Black women, Learning, Culture, BAPE, KAWS, Gilead Sciences, Nike, CEO, Sony, Industry, Organization, Director, Board, Mechanics, Hospital, Adidas, Catalog, Multimedia, CFO, UCSF Benioff Children's Hospital, Supreme, Mastercard, Alphabet Inc., Microsoft, Mastercard Foundation, Salesforce, Management

"As a Detroit native, I've long been inspired by StockX -- its roots in community, commitment to culture, and incredible global expansion are just a few of the reasons the company has been able to fundamentally change how people consume and trade around the world," said Washington. "It is a true privilege to join the Board of Directors. In addition to bringing my experience scaling global businesses and pushing the limits of technology to bear for StockX, I'm also committed to helping them foster a diverse, inclusive and innovation-focused culture for years to come."

Key Points: 
  • DETROIT, Dec. 8, 2021 /PRNewswire/ -- StockX today announced the appointment of its newest board member and Audit Committee Chair, Robin Washington .
  • Washington, a greater Detroit native, is a renowned industry leader with deep experience as an advisor for tech and life science companies.
  • She currently serves on the boards of Alphabet Inc., Salesforce, Honeywell International, the Mastercard Foundation, and UCSF Benioff Children's Hospitals.
  • Today, we're thrilled to welcome her to the StockX board as the Chair of our Audit Committee," said Scott Cutler, CEO of StockX.

St. Baldrick's Foundation Awards 24 Infrastructure Grants to Help Institutions Bring Lifesaving Clinical Trials Closer to Home

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星期三, 十一月 17, 2021
Volunteering, Patient, CEO, Foundation, Hospital, University of California, San Francisco, Cancer, University, COVID-19, UCSF Benioff Children's Hospital, Ventura County Medical Center, Hope, Survival, American Society of Pediatric Hematology/Oncology, Research, Organization, Travel, Pharmaceutical industry, Dietary supplement

LOS ANGELES, Nov. 17, 2021 /PRNewswire/ -- The past couple of years have presented challenges to many non-profit organizations and especially to kids with cancer. The St. Baldrick's Foundation, the largest non-government funder of childhood cancer research grants, is proud to announce the funding of 24 infrastructure grants totaling more than $1.1 million in lifesaving childhood cancer research.

Key Points: 
  • The St. Baldrick's Foundation , the largest non-government funder of childhood cancer research grants , is proud to announce the funding of 24 infrastructure grants totaling more than $1.1 million in lifesaving childhood cancer research.
  • Since COVID-19 has entered our lives, the added question of how to travel safely has become a topic of conversation.
  • These one-year grants provide the selected institutions the staffing to open, coordinate, and treat more children on clinical trials , making it possible for more children to access these trials close to home.
  • "St. Baldrick's Infrastructure Grants are designed for one reason, to treat more children on clinical trials, often their best hope for a cure," said Kathleen Ruddy, St. Baldrick's CEO.

Festival Napa Valley Announces the Olivia Decker Power of Music Series

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星期二, 十一月 9, 2021
Restaurant, Music, Student, UCSF Benioff Children's Hospital, CEO, Corinthian Yacht Club, Hospital, Decker, Wine, Sotheby's International Realty, Beauty, Holiday, Silicon, San Francisco Opera, Human, Bank, San Francisco Symphony, Advisory board, Seawanhaka Corinthian Yacht Club, Festival, San Francisco Bay, Olivia, Entertainment

NAPA,Calif., Nov. 9, 2021 /PRNewswire/ -- Festival Napa Valley is honored to announce the creation of the Olivia Decker Power of Music Series.

Key Points: 
  • NAPA,Calif., Nov. 9, 2021 /PRNewswire/ -- Festival Napa Valley is honored to announce the creation of the Olivia Decker Power of Music Series.
  • Launched with a $5 million gift from Festival Napa Valley board member Olivia Decker, the series showcases globally recognized performing artists and emerging talent in live presentations in Marin County, Napa Valley and beyond.
  • Supporting Festival Napa Valley to create this series allows me to share my love of music at the highest level of presentation possible," stated Decker.
  • "Olivia's enthusiasm for sharing outstanding music and Festival Napa Valley's commitment to reach new audiences find a perfect pairing in the Olivia Decker Power of Music Series.

Innovative Cancer Treatments, Research in Regenerative Medicine and Gene Therapy to Be Presented at World Cord Blood Day 2021

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星期二, 十月 19, 2021
Temperature, Foundation, NMDP, Nursing, Bone marrow, Stroke, Partner, Hospital, Transplant, Lymphoma, UCSF Benioff Children's Hospital, Royal Manchester Children's Hospital, Autism, Cerebral palsy, Social media, Method, FACT, Regenerative medicine, Research, Laboratory, Parent, Saint Louis Hospital (Bangkok), University, World Marrow Donor Association, University of Minnesota, Leukemia, Accreditation, Blood, Fred Hutchinson Cancer Research Center, Thalassemia, Sickle cell disease, Cas9, Student, Medical device

TUCSON, Ariz., Oct. 19, 2021 /PRNewswire/ --Register now for the World Cord Blood Day 2021 virtual conference to be held on November 15th, 2021 ( register free via Eventbrite open to the public).

Key Points: 
  • TUCSON, Ariz., Oct. 19, 2021 /PRNewswire/ --Register now for the World Cord Blood Day 2021 virtual conference to be held on November 15th, 2021 ( register free via Eventbrite open to the public).
  • The World Cord Blood Day 2021 ( www.WorldCordBloodDay.org ) virtual conference will provide an opportunity for healthcare professionals, expectant parents, students and the general public to learn about life-saving cord blood stem cells via a mix of livestream and on-demand sessions.
  • In the on-demand sessions, pioneering cord blood research will be presented in the emerging fields of gene therapy (CRISPR/Cas9) to treat sickle cell disease and regenerative medicine to potentially treat autism, cerebral palsy, stroke and more.
  • For over forty years, QuickSTAT has been entrusted with transporting human organs and tissue for transplant or research, blood, blood products, cord blood, bone marrow, medical devices, and personalized medicine, 24/7/365.

Study Shows the Combination of OGM and NGS with Linked-Reads Detects Significantly More Clinically Relevant Variants Resulting in Higher Success Rates for Resolving Previously Unclassified Subjects in Genetic Disease Research

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星期四, 十月 14, 2021
Data analysis, Genetic testing, WES, WGS, San Francisco, Diagnosis, Genome, UCSF Benioff Children's Hospital, Private Securities Litigation Reform Act, Adoption, Security (finance), Doctor of Philosophy, FGA, NHEJ1, Genomics, Degenerative disease, University of California, San Francisco, Genetics, Lineagen, Disease, Cytogenetics, Karyotype, Deletion, OGM, Autism, GLOBE, Chromosomal translocation, U.S. Securities and Exchange Commission, ASD, NGS, Forward-looking statement, SAN, University, Annual report, Children's Hospital Oakland Research Institute, CEO, Chromosome, UCSF, SVS, Genetic distance, Research, Whole genome sequencing, COVID-19, Medical imaging, Pharmaceutical industry, Risk management

The authors also identified candidate variants in another 60% (18 of 30 cases) for future follow-up.

Key Points: 
  • The authors also identified candidate variants in another 60% (18 of 30 cases) for future follow-up.
  • FGA provides information beyond current assays and results in higher resolution genome maps that can be used for future studies.
  • Fifty percent of the participants in this study had clinically relevant variants hidden in their genomes that WES alone had not uncovered.
  • We believe there is tremendous potential in using OGM together with NGS to understand disease from the very beginning of any study.

Cleo Launches Clinical Advisory Board to Further Health Outcomes and Support for Today’s Working Families

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星期三, 九月 8, 2021
Technology, Parenting, Human Resources, Baby, Maternity, Professional Services, Software, Family, General Health, Consumer, Health

Cleo , the most comprehensive support benefit for working families, today announced its Clinical Advisory Board consisting of five industry leading and forward thinking health professionals in critical areas of support for todays working families.

Key Points: 
  • Cleo , the most comprehensive support benefit for working families, today announced its Clinical Advisory Board consisting of five industry leading and forward thinking health professionals in critical areas of support for todays working families.
  • From mental health to chronic illness, todays families face a range of challenges that call for more specialized support.
  • Cleos Clinical Advisory Board brings together diverse experts across pediatric and family health to drive forward sustained, positive health outcomes for its member base during what has become a historical 18 months for working parents.
  • Cleo is the most comprehensive support benefit for working families, reinventing how forward-thinking employers improve family health, control costs and attrition and build inclusive cultures.

COVID-19: Transmission and Therapeutics

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星期二, 八月 17, 2021
Sepsis, Society, COVID, SAGE, Research, Teaching hospital, Chief Dental Officer (Canada), Hospital, Review, A2, UCSF Benioff Children's Hospital, Mechanical, Department, University, Therapy, Fomite, Severe acute respiratory syndrome coronavirus 2, Emory University School of Medicine, Division, Manuscript, Pediatrics, Experimental biology, Experimental Biology and Medicine, Central Florida, Sickle cell disease, Spread, Exercise, Aerosol, University of Montenegro Faculty for Sport and Physical Education, Multisystem inflammatory syndrome, Faculty, EBM, Infection, End organ damage, Biology, RNA, Experimental Biology and Medicine (Society for Experimental Biology and Medicine journal), Internal medicine, Inflammation, Multimedia, Patient, Physical education, Dental, Pharmaceutical industry, Vaccine

The Editor-in-Chief is currently handling manuscripts that focus on COVID to ensure that each paper undergoes a rapid yet thorough review.

Key Points: 
  • The Editor-in-Chief is currently handling manuscripts that focus on COVID to ensure that each paper undergoes a rapid yet thorough review.
  • (in press) review the impact of COVID-19 on dental offices, infection mitigation strategies.
  • The rapid spread of COVID-19 also greatly enhances the need for novel interventions and therapeutics.
  • For anyone interested in submitting a manuscript for consideration or viewing other articles published in the journal, please visit http://ebm.sagepub.com .