Hydroxychloroquine

Incannex Healthcare Inc. Quarterly Update, Q1 2024

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星期二, 四月 16, 2024

MELBOURNE, Australia, April 16, 2024 (GLOBE NEWSWIRE) -- Clinical stage pharmaceutical development company, Incannex Healthcare Inc. (NASDAQ: IXHL), (‘Incannex’ or the ‘Company’), is pleased to provide quarterly activities update and for the quarter ended 31 March 2024.

Key Points: 
  • MELBOURNE, Australia, April 16, 2024 (GLOBE NEWSWIRE) -- Clinical stage pharmaceutical development company, Incannex Healthcare Inc. (NASDAQ: IXHL), (‘Incannex’ or the ‘Company’), is pleased to provide quarterly activities update and for the quarter ended 31 March 2024.
  • Incannex is undertaking various U.S. Food and Drug Administration (‘FDA’) research and development (‘R&D’) programs for cannabinoid pharmaceutical products and psychedelic medicine therapies.
  • During the quarter, Incannex released top line results from the PsiGAD1 clinical trial conducted at Monash University, based in Melbourne, Australia.
  • This announcement has been approved for release to NASDAQ by the Incannex Board of Directors.

Infectious Disease Specialist Calls Campaign against Repurposed Drugs in COVID-19 a ‘Great Hypocrisy’

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星期四, 三月 21, 2024

Just before the death-knell announcement, Dr. Hoffman notes, substantial evidence favoring early use of HCQ had been submitted for publication by Dr. Harvey Risch of Yale.

Key Points: 
  • Just before the death-knell announcement, Dr. Hoffman notes, substantial evidence favoring early use of HCQ had been submitted for publication by Dr. Harvey Risch of Yale.
  • “In fact, all evidence is inherently flawed.”
    Dr. Hoffman points out how inconsistencies and double standards reveal the FDA’s hypocrisy regarding HCQ and ivermectin (IVM).
  • Paxlovid, he writes, has not been shown to be effective in hospitalized COVID patients, whereas the “flawed” study of HCQ demonstrated a greater than 60 percent benefit in reducing mortality.
  • “There is in fact a corpus of knowledge about the use of HCQ, IVM, and other off-label drugs, for example, at c19hcq.org, c19IVM.org18, and earlycovidcare.org,” Dr. Hoffman states.

How memes transformed from pics of cute cats to health disinformation super-spreaders

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星期一, 二月 12, 2024

Our research shows that memes form part of a highly sophisticated strategy to spread and monetise health disinformation.

Key Points: 
  • Our research shows that memes form part of a highly sophisticated strategy to spread and monetise health disinformation.
  • Dismissing them as harmless jokes is to grossly underestimate their influence – and bolsters their power to spread potentially harmful health messages.

Anti-vaccine memes have a long history


Memes aren’t a recent invention. They have featured prominently in anti-vaccination messaging for centuries.
When widespread smallpox immunisation began in the early 19th century, political cartoons published in print media used memes (see image below) to evoke fear about the safety of the vaccine.

  • The meme “vaccines cause autism”, which appeared on billboards and was circulated widely in the media, provoked doubts about the safety of the vaccine.
  • The internet enables memes to be created anonymously, repurposed and shared at scale – making them a highly effective medium for spreading health disinformation.
  • Memes play an integral role in disinformation campaigns by facilitating fear, uncertainty and doubt.

Influencers and money

  • Our study analysed how popular anti-vaccine influencers used memes to galvanise the anti-vaccine movement during the COVID pandemic.
  • First, memes were used to vilify the government and social institutions, portraying them as corrupt and politically compromised.
  • Influencers suggested the unvaccinated were being persecuted, using evocative imagery to imply a false equivalence between those who remain unvaccinated by choice and the persecution of Jews during the Holocaust.
  • Vaccination was associated with infertility, low sex drive and a lack of critical thinking.
  • To establish group membership and promote a sense of belonging, influencers referred to those who are anti vaccines as their “soul family”.

Going viral – and avoiding challenge

  • Several influencers provided their followers with “meme drops”: packages of memes with dissemination instructions.
  • These memes were tested and produced in meme factories, then distributed monthly to a mass audience via personal newsletters and websites, encouraging followers to spread anti-vaccination content.
  • By adapting memes to current affairs, influencers increased their relevance and likelihood of going viral.
  • Under the protective guise of humour and satire, memes can evade fact checkers and content moderators while promoting anti-vaccine myths and unauthorised treatments.
  • Memes may not look threatening – but that’s why they are such effective super spreaders of health disinformation.


The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

Incannex Commences Dosing in Phase 2 Clinical Trial Assessing IHL-675A in Patients with Rheumatoid Arthritis

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星期三, 一月 24, 2024

The primary endpoint of the double-blind, Phase 2 clinical trial is pain and function relative to baseline determined via the score on the RAPID-3 assessment at 24 weeks.

Key Points: 
  • The primary endpoint of the double-blind, Phase 2 clinical trial is pain and function relative to baseline determined via the score on the RAPID-3 assessment at 24 weeks.
  • Chief Scientific Officer of Incannex, Dr. Mark Bleackley, said; “Commencing dosing in the Phase 2 clinical trial in patients with RA is an exciting milestone for the development of IHL-675A.
  • Millions of people are affected by pain associated with rheumatoid arthritis despite the available treatment options.
  • Overview of Results from Phase 1 Clinical Trial Assessing Tolerability, Safety, and Pharmacokinetics of IHL-675A in Healthy Volunteers
    In 2022 and 2023, Incannex undertook a Phase 1 clinical trial to assess the safety, tolerability, and pharmacokinetics of IHL-675A.

Accountability Needed for COVID Debacle, according to the Journal of American Physicians and Surgeons

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星期三, 十二月 13, 2023

Dr. Hatfill served as a medical/scientific advisor to the Executive Office of the President during the Trump Administration.

Key Points: 
  • Dr. Hatfill served as a medical/scientific advisor to the Executive Office of the President during the Trump Administration.
  • Early results from overseas were promising, and by July 2020, early-use HCQ had been shown to reduce COVID hospital mortality by more than 50 percent.
  • Investigation requires legal experts, forensic accountants, scientific experts, and physicians, Dr. Hatfill concludes.
  • The Journal of American Physicians and Surgeons is published by the Association of American Physicians and Surgeons (AAPS), a national organization representing physicians in all specialties since 1943.

Incannex Receives HREC Approval for Phase 2 Clinical Trial Assessing IHL-675A for use in Treatment of Pain and Function in Rheumatoid Arthritis

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星期四, 七月 13, 2023

MELBOURNE, Australia, July 13, 2023 (GLOBE NEWSWIRE) -- Incannex Healthcare Limited (Nasdaq: IXHL) (ASX: IHL), (‘Incannex’ or the ‘Company’), a clinical-stage pharmaceutical company developing unique medicinal cannabinoid pharmaceutical products and psychedelic medicine therapies for unmet medical needs, is pleased to announce that it has received approval from Bellberry Human Research Ethics Committee (‘HREC’) for the lead site, Emeritus Research, Camberwell, Victoria, for its Phase 2 clinical trial. The trial is pivotal in nature and will assess the efficacy of IHL-675A, its proprietary anti-inflammatory combination drug product, in patients with rheumatoid arthritis (‘RA’).

Key Points: 
  • Incannex has received approval from HREC for the lead site, Emeritus Research, Camberwell, VIC for the Phase 2, Blinded, Placebo Controlled Clinical Trial to Determine the Effect on Pain and Function of IHL-675A in Patients with Rheumatoid Arthritis.
  • The Phase 2 trial follows a successful Phase 1 trial where IHL-675A was observed to be well tolerated and safe.
  • This trial will be managed by Avance Clinical, an Australian and US CRO, who will engage 8-10 clinical trial sites across Australia and New Zealand, recruiting 128 patients in total.
  • Incannex Chief Scientific Officer Dr Mark Bleackley said: “HREC approval for the Phase 2 clinical trial is a key step in the development of IHL-675A for treatment of pain and reduced function associated with rheumatoid arthritis.

New Research on Emerging Cutaneous Lupus Erythematosus (CLE) Market Reveals Vast Potential for Pipeline Agents, According to Spherix Global Insights

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星期一, 五月 8, 2023

EXTON, Pa., May 8, 2023 /PRNewswire/ -- According to the Lupus Foundation of America, approximately two-thirds of people with the autoimmune condition systemic lupus erythematosus (SLE) will develop some type of skin disease, called cutaneous lupus erythematosus (CLE). Skin disease in lupus can cause rashes or lesions, most of which will appear on the sun-exposed areas of the body.

Key Points: 
  • EXTON, Pa., May 8, 2023 /PRNewswire/ -- According to the Lupus Foundation of America , approximately two-thirds of people with the autoimmune condition systemic lupus erythematosus (SLE) will develop some type of skin disease, called cutaneous lupus erythematosus (CLE).
  • Skin disease in lupus can cause rashes or lesions, most of which will appear on the sun-exposed areas of the body.
  • – Rheumatologist
    There are currently no specific FDA-approved therapies for cutaneous lupus erythematosus (CLE) or discoid lupus erythematosus (DLE) – conditions which mostly affect women and people of color.
  • Spherix Global Insight's Market Dynamix™ Cutaneous Lupus Erythematosus service focuses on this evolving market, where a paradigm shift is expected within the next few years.

Incannex Announces Final Results from Phase 1 Clinical Trial Assessing Safety and Pharmacokinetics of IHL-675A

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星期二, 五月 2, 2023

The Phase 1 trial measured the safety, tolerability, and pharmacokinetic profiles of IHL-675A compared to the reference listed drugs, Epidiolex (CBD) and Plaquenil (HCQ).

Key Points: 
  • The Phase 1 trial measured the safety, tolerability, and pharmacokinetic profiles of IHL-675A compared to the reference listed drugs, Epidiolex (CBD) and Plaquenil (HCQ).
  • Three cohorts of 12 participants (n = 36) received either IHL-675A, CBD or HCQ and the clinical assessments were identical across the three arms of the trial.
  • The trial was conducted by CMAX Clinical Research in Adelaide, South Australia and managed by Avance Clinical.
  • Incannex Chief Scientific Officer Dr Mark Bleackley said: “The results from the Phase 1 trial are a critical milestone in the development of IHL-675A.

Incannex Commences Phase 2 Clinical Trial Assessing IHL-675A for use in Treatment of Pain and Function in Rheumatoid Arthritis

Retrieved on: 
星期二, 二月 28, 2023

SYDNEY, Australia, Feb. 28, 2023 (GLOBE NEWSWIRE) -- Incannex Healthcare Limited (Nasdaq: IXHL) (ASX: IHL), (‘Incannex’ or the ‘Company’) a pharmaceutical company developing proprietary medicinal cannabinoid products and psychedelic medicine therapies for unmet medical needs, is pleased to announce that it has commenced a Phase 2 clinical trial to assess the safety and efficacy of its proprietary anti-inflammatory combination drug IHL-675A in patients with rheumatoid arthritis (‘RA’). IHL-675A is a proprietary fixed dose combination drug comprising cannabidiol (CBD) and hydroxychloroquine (‘HCQ’).

Key Points: 
  • Incannex has commenced a Phase 2, Blinded, Placebo Controlled Clinical Trial to Determine the Safety and Effect on Pain and Function of IHL-675A in Patients with Rheumatoid Arthritis.
  • The trial will assess the effect of IHL-675A on pain and function by utilising patient reported outcomes, disease scores and inflammatory biomarker analysis over a 24-week period.
  • There will be an option for trial participants to participate in an extension study following the trial.
  • This Phase 2 clinical trial follows the successful Phase 1 clinical trial whereby IHL-675A was observed to be well tolerated, with no adverse events of concern.

Global Antimalarial Drugs Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028

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星期四, 十二月 22, 2022

Key Points: 
  • Additionally, rise in malaria death cases, especially in developing nations are also fueling the growth of antimalarial drugs market.
  • Based on route of administration, the global antimalarial drugs market is segmented into oral, powder inhalation and intravenous administration.
  • • To analyze and forecast the market size of global antimalarial drugs market.
  • In this report, global antimalarial drugs market has been segmented into following categories, in addition to the industry trends which have also been detailed below:
    • Global Antimalarial Drugs Market, By Drug Type: