European Research Council

The International Myeloma Foundation and Black Swan Research Initiative® Announce the Release of New iStopMM Cohort Study: A Multivariable Prediction Model for Bone Marrow Sampling on Individuals with MGUS

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星期四, 四月 11, 2024

IMF Chief Scientific Officer and co-author of the iStopMM cohort study Dr. Brian G.M.

Key Points: 
  • IMF Chief Scientific Officer and co-author of the iStopMM cohort study Dr. Brian G.M.
  • Groups 2 and 3 were evaluated at the study clinic for initial assessment and follow-up, including bone marrow sampling,” according to the study.
  • However, [this] model requires validation in other populations.”
    To know the full details of the iStopMM cohort study , view it online.
  • This research was funded by the International Myeloma Foundation and the European Research Council.

Ancient nomads you’ve probably never heard of disappeared from Europe 1,000 years ago. Now, DNA analysis reveals how they lived

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星期四, 四月 25, 2024

For centuries, our main sources of information have been pottery sherds, burial sites and ancient texts.

Key Points: 
  • For centuries, our main sources of information have been pottery sherds, burial sites and ancient texts.
  • But the study of ancient DNA is changing what we know about the human past, and what we can know.

Who were the Avars?


The Avars were a nomadic people originating from eastern central Asia. From the 6th to the 9th century CE, they wielded power over much of eastern central Europe.

  • The Avars are renowned among archaeologists for their distinctive belt garnitures, but their broader legacy has been overshadowed by predecessors such as the Huns.
  • Nevertheless, Avar burial sites provide invaluable insights into their customs and way of life.

Kinship patterns, social practices and population dynamics

  • We combined ancient DNA data with archaeological, anthropological and historical context.
  • As a result, we have been able to reconstruct extensive pedigrees, shedding light on kinship patterns, social practices and population dynamics of this enigmatic period.


We sampled all available human remains from four fully excavated Avar-era cemeteries, including those at Rákóczifalva and Hajdúnánás in what is now Hungary. This resulted in a meticulous analysis of 424 individuals. Around 300 of these individuals had close relatives buried in the same cemetery. This allowed us to reconstruct multiple extensive pedigrees spanning up to nine generations and 250 years.

Communities were organised around main fathers’ lines

  • Our results suggest Avar society ran on a strict system of descent through the father’s line (patrilineal descent).
  • In contrast, women played a crucial role in fostering social ties by marrying outside their family’s community.
  • Our study also revealed a transition in the main line of descent within Rákóczifalva, when one pedigree took over from another.
  • Our results show an apparent genetic continuity can mask the replacement of entire communities.

Future direction of research


Our study, carried out with researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany and at Eötvös Loránd University in Budapest, Hungary, is part of a larger project called HistoGenes funded by the European Research Council. This project shows we can use ancient DNA to examine entire communities, rather than just individuals. We think there is a lot more we can learn.

  • Now we aim to deepen our understanding of ancestral Avar society by expanding our research over a wider geographical area within the Avar realm.
  • Additionally, we plan to study evidence of pathogens and disease among the individuals in this research, to understand more about their health and lives.
  • Another avenue of research is improving the dating of Avar sites.
  • Bunbury receives funding from the Australian Research Council (ARC) (project number CE170100015).
  • Guido Alberto Gnecchi-Ruscone receives funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 856453.

Five things our research uncovered when we recreated 16th century beer (and barrels)

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星期五, 四月 19, 2024

But why they did so and what their beer was like are questions shrouded in myth.

Key Points: 
  • But why they did so and what their beer was like are questions shrouded in myth.
  • Combining craft, microbiology, brewing science, archaeology, as well as history, this was the most comprehensive interdisciplinary study of historical beer ever undertaken.

1. People didn’t drink beer because water was unhealthy

  • It’s often assumed that lack of access to clean water led people to drink beer instead.
  • We know this isn’t true for many reasons, not least because brewers needed a constant source of fresh water to make the best beer.

2. Beer was a payment for work

  • Treatments for conditions such as flux or bed wetting, for example, required ground kid’s hoof or grated stag’s penis to be taken with a drink of beer.
  • At Christchurch Cathedral in Dublin, masons received up to 15 pints per day when undertaking heavy work.

3. Beer had some different ingredients then

  • The key ingredients were malt (made from barley or oats depending on the region), water, yeast and hops.
  • This resulted in a longer lasting drink, accelerating the development of the brewing industry as we know it today.
  • But there are differences between pre-modern and modern beers, relating primarily to the nature of the ingredients.

4. Making beer required skills in short supply today

  • Brewers were deeply in tune with their working conditions and didn’t have modern devices such as thermometers.
  • As the project team learned the hard way, small mistakes could be disastrous, resulting in spoiled beer and accidental porridge.
  • Recreating the technology of the past also highlighted the wider craft skills, such as coopering (making barrels), wicker-weaving, woodworking, and coppersmithing, that went into making all the equipment needed to make a pint.

5. Even everyday beer was strong

  • Based on little evidence, it is assumed that beer of around 2% alcohol by volume (abv) was the most common drink of the working classes.
  • Our experiment showed that a typical beer of middling strength actually had the potential to be around 5% abv, comparable to modern lager.
  • Those calls often came, however, from the same people who liberally supplied their workers with beer.


The FoodCult project is funded by the European Research Council (Grant Agreement 803486) Charlie Taverner also works as a policy lead for the food systems NGO, the Food, Farming and Countryside Commission.

Foresight Institute Announces 2023 Feynman Prize Winners

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星期日, 十月 29, 2023

SAN FRANCISCO, Oct. 29, 2023 /PRNewswire-PRWeb/ -- Established in 1986, Foresight Institute is a pioneering non-profit organization dedicated to the advancement of molecular manufacturing and transformative technologies. Navigating scientific areas often seen as too ambitious for traditional institutions, Foresight Institute is committed to shaping the long-term future of life through these technologies. Awarded since 1993, Foresight Institute's Feynman Prizes celebrate both established and emerging talents in the field of nanotechnology, embodying their vision of steering transformative technologies to benefit humanity.

Key Points: 
  • SAN FRANCISCO, Oct. 29, 2023 /PRNewswire-PRWeb/ -- Established in 1986, Foresight Institute is a pioneering non-profit organization dedicated to the advancement of molecular manufacturing and transformative technologies.
  • Navigating scientific areas often seen as too ambitious for traditional institutions, Foresight Institute is committed to shaping the long-term future of life through these technologies.
  • Awarded since 1993, Foresight Institute's Feynman Prizes celebrate both established and emerging talents in the field of nanotechnology, embodying their vision of steering transformative technologies to benefit humanity.
  • Foresight Institute also bestows the Distinguished Student Award, spotlighting an upcoming individual for their exceptional work in advancing nanotechnology development and understanding.

Spexis announces the appointment of Gonçalo Bernardes, Ph.D., as acting Head of Chemical Biology

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星期四, 九月 28, 2023

Spexis announces the appointment of Gonçalo Bernardes, Ph.D., as acting Head of Chemical Biology

Key Points: 
  • Spexis announces the appointment of Gonçalo Bernardes, Ph.D., as acting Head of Chemical Biology
    Spexis announces the appointment of Gonçalo Bernardes, Ph.D., as acting Head of Chemical Biology
    Spexis AG (SIX: SPEX), a clinical-stage biopharmaceutical company focused on rare diseases and oncology, today announced that the company has appointed Gonçalo Bernardes, PhD, as acting Head of Chemical Biology.
  • “We are thrilled to welcome Gonçalo to Spexis, where we look forward to leveraging his expertise in chemical biology to advance the development of our novel macrocycle pipeline,” said Jeff Wager, M.D., Chairman & CEO of Spexis.
  • “Spexis remains committed to strengthening our leading position in macrocycle-based therapeutics with our two distinct and well characterized libraries, PEMFinder and MACROFinder.
  • Spexis continues to leverage its macrocycle platform into new therapeutic modalities and the company expects to provide further details on their progress later this year.

Spexis announces the appointment of Gonçalo Bernardes, Ph.D., as acting Head of Chemical Biology

Retrieved on: 
星期四, 九月 28, 2023

ALLSCHWIL, Switzerland, Sept. 27, 2023 (GLOBE NEWSWIRE) -- Spexis AG (SIX: SPEX), a clinical-stage biopharmaceutical company focused on rare diseases and oncology, today announced that the company has appointed Gonçalo Bernardes, PhD, as acting Head of Chemical Biology.

Key Points: 
  • ALLSCHWIL, Switzerland, Sept. 27, 2023 (GLOBE NEWSWIRE) -- Spexis AG (SIX: SPEX), a clinical-stage biopharmaceutical company focused on rare diseases and oncology, today announced that the company has appointed Gonçalo Bernardes, PhD, as acting Head of Chemical Biology.
  • “We are thrilled to welcome Gonçalo to Spexis, where we look forward to leveraging his expertise in chemical biology to advance the development of our novel macrocycle pipeline,” said Jeff Wager, M.D., Chairman & CEO of Spexis.
  • “Spexis remains committed to strengthening our leading position in macrocycle-based therapeutics with our two distinct and well characterized libraries, PEMFinder and MACROFinder.
  • Spexis continues to leverage its macrocycle platform into new therapeutic modalities and the company expects to provide further details on their progress later this year.

The Consortium for the protection of Barolo Barbaresco Alba Langhe e Dogliani presents Barolo en primeur in the United States

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星期四, 九月 7, 2023

The evenings will consist of two masterclasses conducted by Matteo Ascheri, president of the Consortium for the protection of Barolo Barbaresco Alba Langhe e Dogliani to the Ordine dei Cavalieri del Tartufo e dei Vini di Alba of the respective U.S. delegations.

Key Points: 
  • The evenings will consist of two masterclasses conducted by Matteo Ascheri, president of the Consortium for the protection of Barolo Barbaresco Alba Langhe e Dogliani to the Ordine dei Cavalieri del Tartufo e dei Vini di Alba of the respective U.S. delegations.
  • The territories involved in the activity are in order of tasting: Verduno, La Morra and Grinzane, Roddi and Castiglione, Barolo, Novello and Monforte, and Serralunga.
  • This activity, together with Barolo en primeur 2022 is a social responsibility initiative promoted by the CRC Foundation, in collaboration with the Consortium for the protection of Barolo Barbaresco Alba Langhe and Dogliani: a charity competition to support socially useful projects, both in Italy and abroad.
  • The aim of this activity and another project, which is the Barolo en primeur auction, in collaboration with the CRC Foundation Cuneo and Christie's, is to highlight the potential of en primeur tastings to raise awareness, appreciation and promotion of both Barolo and Barbaresco.

Barolo and Barbaresco fly to China for Vinitaly China Roadshow

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星期二, 九月 5, 2023

The activities in China include the participation of more than 85 Barolo and Barbaresco companies in various industry fairs and the organization of several workshops.

Key Points: 
  • The activities in China include the participation of more than 85 Barolo and Barbaresco companies in various industry fairs and the organization of several workshops.
  • From Sept. 11 to 15, 2023 as part of Vinitaly China Roadshow, the Veronafiere-branded event, Barolo and Barbaresco will be the stars of the days on a taste itinerary between Beijing, Changsha and Hangzhou.
  • The last event will be in Hangzhou, one of the most important cities in coastal China at 1366 Qianjiang Road, Shangcheng District.
  • The purpose is to educate wine professionals in emerging cities and create a tasting area with food & Barolo and Barbaresco pairing tastings.

GIFS researcher supports international team effort to sequence earliest domesticated wheat genome

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星期三, 八月 30, 2023

More than two dozen scientists have contributed to a project that that has sequenced and characterized genomes of wild and domesticated einkorn, the world’s first domesticated wheat species.

Key Points: 
  • More than two dozen scientists have contributed to a project that that has sequenced and characterized genomes of wild and domesticated einkorn, the world’s first domesticated wheat species.
  • “Though significant advances have been made in wheat species genomics, the species Triticum monococum (einkorn), representing the earliest domesticated wheat, was not defined yet,” said Datla.
  • “The insights gained from genome sequencing wild and domesticated accessions allow us to reconstruct the origin and evolution of einkorn,” said Datla.
  • In 2020, a team, led by USask’s Dr. Curtis Pozniak (PhD), sequenced the genomes for 15 different wheat varieties.

BIAL Award in Biomedicine worth 300,000 Euros

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星期三, 四月 26, 2023

TROFA, Portugal, April 26, 2023 /PRNewswire/ -- The third edition of the BIAL Foundation's international award, the BIAL Award in Biomedicine, is now underway, with nominations open until 30 June. With the amount of 300 thousand Euros, this award aims to recognise a work of a broad biomedical nature with exceptional quality and scientific relevance results published within the last ten years.

Key Points: 
  • TROFA, Portugal, April 26, 2023 /PRNewswire/ -- The third edition of the BIAL Foundation's international award, the BIAL Award in Biomedicine, is now underway, with nominations open until 30 June.
  • With the amount of 300 thousand Euros, this award aims to recognise a work of a broad biomedical nature with exceptional quality and scientific relevance results published within the last ten years.
  • Candidates for this international award may be nominated by members of the Jury, members of the Scientific Board of the BIAL Foundation, previous BIAL Award winners, Scientific Societies, Boards or Deans of Medical Faculties, Heads of leading research institutes, and Boards or Heads of prestigious Academies.
  • The BIAL Award in Biomedicine takes place biannually, in odd-numbered years, alternating with the Prémio BIAL de Medicina Clínica.