Penile spines

• These new findings strongly support previous studies where GAL-201 was characterized as a promising development candidate for the treatment of AD ( Russ et.
• The data was presented this week at the International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders ( AD/PD™ 2024: advances in science and therapy ).
• “The positive results presented at AD/PD™ 2024 demonstrate how treatment with GAL-201 has a potential neuroprotective effect and may also improve cognitive function.
• Furthermore, they validate that toxic Aβ oligomers and protofibrils are a major underlying cause of this devastating disease, and not the deposited forms of Aβ.

• Learning new skills correlates with changes in the brain, as evidenced by neuroscience research with animals and functional brain scans in people.
• Presumably, if you master Calculus 1, something is now different in your brain.
• Clinicians and scientists know there are times the brain can make rapid, enduring changes.
• And here’s where it gets really interesting: Psychedelic-assisted psychotherapy appears to tap into this natural neural mechanism.

Psychedelic-assisted psychotherapy

• However, it can be conceptualized as an altered state of consciousness with distortions of perception, modified sense of self and rapidly changing emotions.
• Presumably there is a relaxation of the higher brain control, which allows deeper brain thoughts and feelings to emerge into conscious awareness.
• Psychedelic-assisted psychotherapy combines the psychology of talk therapy with the power of a psychedelic experience.
• Researchers have described cases in which subjects report profound, personally transformative experiences after one six-hour session with the psychedelic substance psilocybin, taken in conjunction with psychotherapy.

A mechanism for psychedelic-induced change

• Psychedelics such as DMT, the active chemical in the plant-based psychedelic ayahuasca, stimulate a receptor cell type, called 5-HT2A.
• It’s only the 5-HT2A receptor inside the cell that facilitates rapid change in neuronal structure.
• And it’s possible psychedelic-assisted psychotherapy uses this naturally occurring neural mechanism to facilitate healing.

A word of caution

• The friend had a mystical experience and came away feeling deeper connections to her family and friends.
• The U.S. Food and Drug Administration in 2019 did approve ketamine, in conjunction with an antidepressant, to treat depression in adults.
• Psychedelic-assisted psychotherapy with MDMA (often called ecstasy or molly) for PTSD and psilocybin for depression are in Phase 3 trials.

• AGN Neuro is the world’s first company to investigate DMT for both the treatment of stroke and traumatic brain injury (TBI).
• AGN Neuro is the first company to test DMT at single escalating concentrations with an IV dose for a 6-hour duration.
• AGN Neuro has now established a single dose regimen which can now be used in its first Phase 2 study for stroke and TBI.
• “Now that we have established the safety of a single sub psychedelic dose of DMT, we are planning to accelerate our DMT Phase 2 studies accordingly, for both stroke and TBI.”