Surrozen Publishes Study in ‘eLife’ Demonstrating the Promise of The Proprietary SWEETS Platform, a Unique Targeted Protein Degradation Technology, to Further Enhance Wnt Signaling
SOUTH SAN FRANCISCO, Calif., June 12, 2024 (GLOBE NEWSWIRE) -- Surrozen, Inc. (Nasdaq: SRZN), a company pioneering targeted therapeutics that selectively modulate the Wnt pathway for tissue repair and regeneration, announced today publication of data in eLife highlighting the potential to enhance Wnt-signal activation in new targeted SWEETS (Surrozen Wnt signal Enhancer Engineered for Tissue Specificity) bispecific antibodies which utilize a unique protein degradation platform that provides alternatives for future clinical applications (Click: HERE).
- These ASGR-targeted SWEETS molecules represent a unique targeted protein degradation (TPD) platform, that functions via multiple mechanisms, and expands the potential opportunities to treat liver diseases through cell or tissue-specific regenerative therapeutics with enhanced Wnt signal activation.
- This review article provided a comprehensive summary of work done by both Surrozen scientists and other researchers in the field on the invention of various Wnt activating platforms.
- This review highlights the exciting progress made in this emerging field and the potential of Wnt agonists in the treatment of numerous tissue degenerative diseases.
- *TPD – Total protein degradation technologies focus on the complex networks of biochemical processes in protein homeostasis and includes removal of damaged proteins and targeted degradation of intracellular, extracellular, and cell-surface proteins with unwanted functions