Nitration

Nitrase Therapeutics Announces Publication in the Journal of Biological Chemistry on the Role of Tyrosine Nitration in Cell Signaling and Cancer Biology

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星期四, 七月 13, 2023
DAMP, Biochemistry, Database, Nitration, STAT1, Tyrosine, Phosphorylation, HER2, Hsps, CCL2, Bioorganic chemistry, Enzyme, Cancer, CXCL12, Sirtuin 2, LCK, Human, SHP2, DSM-IV codes, BCL2, Protein, Journal, B cell, HDAC2, Cell, Drug discovery, JAK2, Histone deacetylase 2, Sirtuin 6, Therapy, Janus kinase 2, SIRT6, SIRT2, Medical imaging

Nitration and phosphorylation overlapped in 879 tyrosine residues in 460 proteins.

Key Points: 
  • Nitration and phosphorylation overlapped in 879 tyrosine residues in 460 proteins.
  • The analysis revealed three major cellular networks that could be impacted by tyrosine nitration, resulting in altered protein function, localization, turnover, and protein-protein interactions.
  • Known sites of tyrosine nitration are also sites of phosphorylation, suggesting an extensive role for nitration in cell signaling, such that tyrosine nitration could profoundly interfere or alternatively complement tyrosine phosphorylation.
  • Tyrosine nitration is associated with different types of cancer by altering metabolic reprogramming and signaling.

Nitrase Therapeutics Presented Data on Role of Novel Nitrases in Regulating Known and Important Cancer Targets at EORTC-NCI-AACR Symposium

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星期一, 十月 31, 2022
EORTC, Investment, The Michael J. Fox Foundation, Nitration, Therapy, MJFF, Transforming protein RhoA, Cancer, CA, GLOBE, Survival, Protein, Sofinnova, Enzyme, Bristol Myers Squibb, CD3, Pharmaceutical industry, PAK4

Nitration of these proteins by specific company-identified nitrases was shown to regulate the activity of the nitro-substrates.

Key Points: 
  • Nitration of these proteins by specific company-identified nitrases was shown to regulate the activity of the nitro-substrates.
  • This unlocks a new treatment approach in cancer developing therapeutics that inhibit the specific nitrases involved in the nitration of oncogenic proteins.
  • The company has identified over 25 nitrases to-date and showed that several play a potential role in cancer.
  • The company has identified the nitro-substrates, the proteins modified by nitrases, for several nitrases that act as important contributors to the onset and progression of cancer.

Nitrase Therapeutics Expands Pipeline to Include Oncology Programs and Adds Seasoned Cancer Experts to Scientific Advisory Board

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星期四, 六月 2, 2022
Histone deacetylase inhibitor, Yale University, The Michael J. Fox Foundation, Divisional Railway Hospital, Golden Rock, Investment, Therapy, Moses Austin, United States Air Force Scientific Advisory Board, AbbVie, Immune system, Novartis Institute for Tropical Diseases, Medicine, Cancer, MJFF, Berkeley, Pathology, University of Maryland, College Park, Cardiovascular disease, SAB, Sofinnova, CA, Biomedical Research, Biology, Cancer research, University of California, San Francisco, Bristol Myers Squibb, University, DRS, Acquisition, Vanderbilt University, Internal medicine, Enzyme, Chiron Corporation, Head, Michael J. Lenardo, Research, UCSF, FDA, GLOBE, San Francisco, Novartis, Board, Nitration, Biophysics, Protein, Pharmaceutical industry, Chemistry

We have discovered that several nitrases and their nitro-substrates play an important role in cancer, both in cancer and in immuno-oncology.

Key Points: 
  • We have discovered that several nitrases and their nitro-substrates play an important role in cancer, both in cancer and in immuno-oncology.
  • With the launch of our oncology program to discover and develop therapeutics against these identified nitrases, we are thrilled to have attracted Drs.
  • Dr. Davidsen added, I am impressed by Nitrase Therapeutics remarkable discovery of a large number of nitrases with broad and diverse biology.
  • I look forward to working with the management team at Nitrase Therapeutics to bring truly unique medicines to patients.

Global Laboratory Chemicals Market (2021 to 2026) - Growth, Trends, COVID-19 Impact and Forecasts - ResearchAndMarkets.com

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星期四, 七月 15, 2021
Chemicals, Plastics, Manufacturing, Chemistry, Physical sciences, Natural sciences, Chemical elements, Dietary minerals, Oxidizing agents, Distillation, Boron, Nitration, Chemical substance, Iodine, Fine chemical

Some of the most common processes that use laboratory chemicals include acid chloride preparations, carboxylation, ion-exchange reactions, nitration, Suzuki coupling, Williamson's ether synthesis amongst few others.

Key Points: 
  • Some of the most common processes that use laboratory chemicals include acid chloride preparations, carboxylation, ion-exchange reactions, nitration, Suzuki coupling, Williamson's ether synthesis amongst few others.
  • These chemicals play an important role in re-crystallization and distillation processes, to manufacture a wide variety of commercial products.
  • Hence, the growing demand from industrial sector is expected to increase the demand for laboratory chemicals.
  • All such developments are expected to increase the demand for laboratory chemicals, during the forecast period.