3Z: Zebrafish mutant model reveals novel drug candidates for ADHD
In a study published in the journal Neuropsychopharmacology, 3Z scientists and collaborators used a uniquely powerful genetic model and unbiased drug screen to identify novel ADHD non-stimulant therapeutics.
- In a study published in the journal Neuropsychopharmacology, 3Z scientists and collaborators used a uniquely powerful genetic model and unbiased drug screen to identify novel ADHD non-stimulant therapeutics.
- First, it was shown that when the human ADHD risk gene Latrophilin 3 was knocked-out in zebrafish, they showed a robust hyperactive behavior, consistent with ADHD.
- In summary, 3Z introduced a genetic model of ADHD in zebrafish and identified five novel putative therapeutics.
- The findings offer a novel tool for understanding ADHD, suggest a novel mechanism for its etiology and identify novel candidate therapeutics.