Sirtuin 1

Tokiwa Phytochemical Co., Ltd. Announces New Cutting-Edge Study Supporting Benefits of SIRTMAX (R) on Healthier Life Expectancy

Retrieved on: 
Thursday, April 22, 2021
Branches of biology, Senescence, Enzymes, Sirtuin 1, Transcription factors, P53, Androgen receptor, Resveratrol, MTOR

The study led by Tokiwa and Professor Koji Nagata reveals that quercetin 3,5,7,3,4-pentamethyl ether (KPMF-8), an active compound of SIRTMAX (R), directly binds with SIRT1 protein and activates SIRT1 far effectively than resveratrol (well-known SIRT activator).

Key Points: 
  • The study led by Tokiwa and Professor Koji Nagata reveals that quercetin 3,5,7,3,4-pentamethyl ether (KPMF-8), an active compound of SIRTMAX (R), directly binds with SIRT1 protein and activates SIRT1 far effectively than resveratrol (well-known SIRT activator).
  • KPMF-8 interacts with SIRT1 directly and stimulates SIRT1 activity by enhancing the binding affinity of SIRT1 with its substrate, Ac-p53 peptide.
  • The binding affinity between SIRT1 and Ac-p53 peptide was enhanced 8.2-fold by KPMF-8, but only 1.4-fold by resveratrol.
  • What\'s more, SIRTMAX (R) is 5 times more potent than resveratrol in activating SIRT1.

Maypro and Tokiwa Announce New Study Supporting the Powerful Anti-Aging Benefits of SIRTMAX®

Retrieved on: 
Wednesday, March 31, 2021
Branches of biology, Senescence, Biology, Sirtuin 1, Transcription factors, P53, Circadian rhythm, Sirtuin

The SIRT1 protein drives many of our cellular activities, like energy metabolism, cell survival, DNA stability, inflammation and circadian rhythms.

Key Points: 
  • The SIRT1 protein drives many of our cellular activities, like energy metabolism, cell survival, DNA stability, inflammation and circadian rhythms.
  • The Sirt1 gene, also known as the longevity gene, recharges mitochondria, the "power plants" of cells, which tend to wind down with age.
  • This study reveals that KPMF-8 activates SIRT1 much more effectively than does resveratrol.
  • KPMF-8 interacts with SIRT1 directly and stimulates SIRT1 activity by enhancing the binding affinity of SIRT1 with its substrate, Ac-p53 peptide.

NAD Dependent Protein Deacetylase Sirtuin 1 - Pipeline Review, H2 2019 - ResearchAndMarkets.com

Retrieved on: 
Tuesday, January 21, 2020
Health, Pharmaceutical, Enzymes, Sirtuin 1, Sirtuin, Protein deacetylase, KIAA1967, Sirtuin 3

The "NAD Dependent Protein Deacetylase Sirtuin 1 - Pipeline Review, H2 2019" drug pipelines has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "NAD Dependent Protein Deacetylase Sirtuin 1 - Pipeline Review, H2 2019" drug pipelines has been added to ResearchAndMarkets.com's offering.
  • NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or SIRT1 or EC 3.5.1.)
  • The latest report NAD Dependent Protein Deacetylase Sirtuin 1 - Pipeline Review, H2 2019, outlays comprehensive information on the NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or SIRT1 or EC 3.5.1.)
  • NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or SIRT1 or EC 3.5.1.)

Shinkowa Pharmaceutical Co., Ltd. Receives an Interim Report of Clinical Research on Oral Intake of NMN (24 Weeks) and Starts Cooperation with Academic Research Institutions

Retrieved on: 
Tuesday, February 19, 2019
Health, Biotechnology, Oncology, Pharmaceutical, Research, Science, Branches of biology, Nucleotides, RTT, GABAA receptor positive allosteric modulators, Life extension, Nicotinamide mononucleotide, Melatonin, NMN, Sirtuin 1, Nicotinamide adenine dinucleotide, Hormone, Nicotinamide

After confirming the appearance of this sirtuin 1 (longevity gene 1), Shinkowa Pharmaceutical has decided to start the next round of clinical research in collaboration with academic research institutions.

Key Points: 
  • After confirming the appearance of this sirtuin 1 (longevity gene 1), Shinkowa Pharmaceutical has decided to start the next round of clinical research in collaboration with academic research institutions.
  • As a result of previous studies, it has been reported an increase particularly in melatonin, growth hormone and other hormones that get lost with age.
  • NMN (-nicotinamide mononucleotide) is a substance contained in the vitamin B3 family and exists in the body of every organism.
  • NAD+ cannot pass through the brain barrier, and therefore the effects that happen when NMN is ingested cannot be expected.