IMM

Immutep Presents Data from Safety Lead-in Phase of AIPAC-003 at ESMO Breast 2024

Retrieved on: 
onsdag, maj 15, 2024
ASX, Patient, CD4, Plasma, MBC, Pharmacodynamics, Safety, Autoimmune disease, RECIST, IMM, Poster, Congress, Blood, CDK, Cancer, Eftilagimod alpha, MHC, Paclitaxel, ESMO, Oncology, CD8, TNBC, Gamma ray, MHC class II, Pharmaceutical industry

SYDNEY, AUSTRALIA, May 15, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) (“Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces encouraging efficacy, safety, and pharmacodynamic data from the safety lead-in of the AIPAC-003 Phase II/III trial presented at the European Society for Medical Oncology (ESMO) Breast Cancer 2024 Congress. This lead-in represents the first ever 90mg dosing of eftilagimod alpha (“efti”), a soluble LAG-3 protein and MHC Class II agonist, given in combination with weekly paclitaxel.

Key Points: 
  • During the immuno-oncology (IO)-chemotherapy treatment of efti and paclitaxel, this patient achieved a partial response (PR) that subsequently turned into a CR.
  • As of the data cut-off (April 3), no dose-limiting toxicities and no treatment-emergent adverse events of grade 3 or higher severity were recorded.
  • Further data updates in terms of safety and efficacy from AIPAC-003 are expected in CY2024.
  • The ESMO Breast 2024 poster will be available on the Posters & Publications section of Immutep’s website.

MARKET MONITOR FINDS PJM WHOLESALE ELECTRICITY MARKETS COMPETITIVE

Retrieved on: 
torsdag, maj 9, 2024
ARR, Sportradar, Policy, Congestion, Load, Electricity, Wind, Kilowatt-hour, MMU, LMP, FTR, PJM Interconnection, Behavior, PJM, IMM, Overalls

EAGLEVILLE, Pa., May 9, 2024 /PRNewswire/ -- PJM Interconnection's wholesale electric energy market produced competitive results during the first three months of 2024, according to the 2024 Quarterly State of the Market Report for PJM: January through March released today by Monitoring Analytics, LLC, the Independent Market Monitor for PJM.

Key Points: 
  • 2024 Quarterly State of the Market Report for PJM: January through March
    EAGLEVILLE, Pa., May 9, 2024 /PRNewswire/ -- PJM Interconnection's wholesale electric energy market produced competitive results during the first three months of 2024, according to the 2024 Quarterly State of the Market Report for PJM: January through March released today by Monitoring Analytics, LLC, the Independent Market Monitor for PJM.
  • The report is the Independent Market Monitor's assessment of the competitiveness of the wholesale electricity markets managed by PJM in 13 states and the District of Columbia.
  • The report includes analysis of market structure, participant behavior and market performance for each of the PJM markets.
  • "Our analysis concludes that the results of the PJM Energy Market were competitive in the first three months of 2024," Bowring said.

Immutep Announces Positive Preliminary Topline Results from TACTI-003 Cohort B

Retrieved on: 
onsdag, april 24, 2024
CPS, Cancer, DCR, HNSCC, Data collection, QOL, Neck, Pembrolizumab, Merck & Co., CQD, ASX, Fast track (FDA), PD-L1, Data, Autoimmune disease, Incidence, Patient, Head, Death, Quality of life, Merck, Neoplasm, IMM, Medical imaging

SYDNEY, AUSTRALIA, April 24, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) (“Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces preliminary topline results from Cohort B of the TACTI-003 (KEYNOTE-PNC-34) Phase IIb trial evaluating eftilagimod alpha (efti) in combination with MSD’s anti-PD-1 therapy KEYTRUDA® (pembrolizumab) as first-line treatment of recurrent/metastatic head and neck squamous cell carcinoma patients (1L HNSCC) with negative PD-L1 expression.

Key Points: 
  • Head and neck squamous cell carcinomas are a heterogenous disease that represent a high unmet medical need regardless of PD-L1 expression.
  • A total of 33 patients with recurrent or metastatic HNSCC have been enrolled into Cohort B.
  • The final number of evaluable patients in Cohort B is expected to be higher and additional data, including complete response rate, will be released together with Cohort A data.
  • Patients in Cohort A are stratified by CPS >1, CPS 1-19, and CPS >20, and the clinical results for these three CPS groups will be evaluated.

Immutep Appoints Leading Research Institute to Conduct First-in-Human Phase I Study of IMP761

Retrieved on: 
torsdag, april 18, 2024
Immutep, Cancer, Safety, Pharmacokinetics, CHDR, Immunotherapy, ASX, Trial of the century, PD-1, Autoimmune disease, Principal, Rheumatoid arthritis, Multiple sclerosis, Immune system, PD, KLH, Autoimmunity, IMM, Vaccine

SYDNEY, AUSTRALIA, April 18, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces it has entered into an agreement with the Centre for Human Drug Research (CHDR), a world-class institute in Leiden, the Netherlands specializing in cutting-edge early-stage clinical drug research, to perform a first-in-human clinical study of IMP761. This proprietary LAG-3 agonist antibody has been designed to restore balance to the immune system and address the underlying cause of many autoimmune diseases.

Key Points: 
  • This proprietary LAG-3 agonist antibody has been designed to restore balance to the immune system and address the underlying cause of many autoimmune diseases.
  • Subject to the relevant ethic and regulatory approvals, the single and multiple ascending dose, placebo-controlled, double-blind, Phase I study will enrol approximately 49 healthy volunteers, with the objective of assessing safety, pharmacokinetics (PK) and pharmacodynamics (PD).
  • We’re very excited to be partnering with Immutep for this critical step in the development plan of their promising antibody.
  • IMP761 remains on target to enter the clinic mid-CY2024 and Immutep looks forward to providing more information as it approaches this important milestone.

Immutep Receives Positive Feedback from the Spanish Medicines Agency for Upcoming TACTI-004 Registrational Trial in Metastatic Non-Small Cell Lung Cancer

Retrieved on: 
onsdag, april 17, 2024
Medication, Cancer, Competence, Statistics, Regulation, CHMP, ASX, Autoimmune disease, Competent authority, AEMPS, NSCLC, IMM, Pharmaceutical industry

SYDNEY, AUSTRALIA, April 17, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces it has received positive feedback from the Spanish Agency for Medicines and Health Products (AEMPS) Competent Authority regarding the Company’s upcoming TACTI-004 Phase III trial of eftilagimod alpha (“efti”) for first line treatment of metastatic non-small cell lung cancer (1L NSCLC).

Key Points: 
  • SYDNEY, AUSTRALIA, April 17, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces it has received positive feedback from the Spanish Agency for Medicines and Health Products (AEMPS) Competent Authority regarding the Company’s upcoming TACTI-004 Phase III trial of eftilagimod alpha (“efti”) for first line treatment of metastatic non-small cell lung cancer (1L NSCLC).
  • Immutep SVP, Regulatory & Strategy, Christian Mueller commented: “We continue to be pleased with our discussions with regulatory bodies around the world regarding our upcoming pivotal TACTI-004 trial and are thankful for the positive feedback and constructive guidance received by AEMPS.
  • Among the other items discussed at the meeting were general aspects of the trial design, including selection of the control arm and statistics, and the specificities of the patient population.
  • Additional interactions with regulatory agencies as well as with other stakeholders and potential partners are ongoing in a productive manner.

UpMetrics Launches Free Impact Framework Building Tool for Impact Organizations

Retrieved on: 
tisdag, mars 26, 2024
Decal, Organization, Learning, Part, SAN, Table, Overalls, Data collection, Nonprofit organization, IMM, Video game

SAN FRANCISCO, March 26, 2024 /PRNewswire-PRWeb/ -- UpMetrics, an impact measurement and management software company, today announced the release of its new and improved Impact Measurement and Management (IMM) Suite, purpose-built to help mission-driven organizations measure, maximize, and showcase the positive social or environmental impact of their work.

Key Points: 
  • As part of this platform rollout, UpMetrics provides free access to the Impact Framework Builder functionality as part of a Starter package offering.
  • "Our Impact Framework Builder is a free, easy-to-use tool that empowers organizations to measure, manage and communicate their impact, paving the way to access mission aligned capital that will maximize outcomes and long-term sustainability."
  • In alignment with their vision towards creating a data-driven ecosystem that drives capital and resources to impact, UpMetrics will be delivering additional updates to its platform throughout 2024, including impact framework publishing tools to connect impact organizations and an advanced two-sided portfolio reporting feature to streamline data collection and information sharing between funders and impact producers.
  • For more information, visit https://upmetrics.com/platform , or register for the free Impact Framework Builder via https://upmetrics.com/getstarted

Thebes Trust Alternate Thought Opens a Path for Directions Toward Building Harmony Among Adversaries

Retrieved on: 
fredag, mars 22, 2024
Universal mind, Communication, Universal law, Ministry (collective executive), Religion, Internet, Vow, Public theology, Society, University, LAS, Sociology, Trust, Spirit, Catalog, Ministry, Family, Probability, Orient, Ordination, IMM

Thus, we will address subjects using Universal Law, applying the cause factors to determine where another path might have been followed. The Trust will work with other graduate metaphysical teachers in association with the International Metaphysical Ministry -- (IMM) - (https://www.internationalmetaphysicalministry.com). Each graduate of the University of Metaphysics is opportunely ordained as a Metaphysical Minister at commencement as they work in their chosen field.

Key Points: 
  • Thebes addresses those subjects by applying universal law, religious precepts, and Sociological norms—Thebes Trust partners with other ordained Metaphysical Ministers.
  • Thebes Trust adheres to the wording of the Ordination and the Vows accepted by William Cadmus.
  • LAS VEGAS, March 22, 2024 /PRNewswire-PRWeb/ -- Thebes Media ( https://www.thebesmedia.com ) officially announces the dawning of its product development for its Ministry.
  • Thus, we will address subjects using Universal Law, applying the cause factors to determine where another path might have been followed.

Immutep Announces First Clinical Data from 90mg Dosing of Efti

Retrieved on: 
tisdag, mars 5, 2024
MBC, Autoimmune disease, Safety, ASX, Observation, Paclitaxel, Patient, Disease, IMM, Cancer, Pharmaceutical industry

Updated safety data from patients with HR-positive/HER2-negative/low metastatic breast cancer (MBC) treated with this innovative immuno-oncology (IO)-chemotherapy combination reveal no treatment-emergent serious adverse events.

Key Points: 
  • Updated safety data from patients with HR-positive/HER2-negative/low metastatic breast cancer (MBC) treated with this innovative immuno-oncology (IO)-chemotherapy combination reveal no treatment-emergent serious adverse events.
  • Additionally, all treatment-emergent adverse events during the safety observation period to date have been of mild severity.
  • The biologically active 30mg efti dose, previously the highest dose of efti ever tested, has demonstrated a stronger immune response and greater efficacy than lower dosing levels (1mg, 6mg) in multiple clinical trials.
  • The ongoing randomized Phase II portion of the trial, which will include up to 58 evaluable patients, is focused on whether 90mg efti dosing is safe and more efficacious than 30mg dosing.

Immutep Quarterly Activities Report Q2 FY24

Retrieved on: 
tisdag, januari 30, 2024
Well, OS, CPS, Survival, PD-L1, Congress, NSCLC, IMM, Lung cancer, Patient, TPS, Safety, Immutep, Pembrolizumab, Cancer, ASX, Autoimmune disease, Pharmaceutical industry

SYDNEY, AUSTRALIA, Jan. 30, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, provides an update on the ongoing development of its product candidates, eftilagimod alpha (efti) and IMP761 for the quarter ended 31 December 2023 (Q2 FY24).

Key Points: 
  • Cash receipts from customers in Q2 FY24 were $38k, compared to $132k in Q1 FY24.
  • The net cash used in G&A activities in the quarter was $0.8 million, compared to $1.6 million in Q1 FY24.
  • The net cash used in R&D activities in the quarter was $6.9 million, compared to $9.7 million in Q1 FY24.
  • Total net cash outflows used in operating activities in the quarter were $5.5 million compared to $12.9 million in Q1 FY24.

First Patient Dosed in Trial Evaluating Efti and the Anti-PD-L1 Therapy BAVENCIO® in Metastatic Urothelial Cancer

Retrieved on: 
torsdag, januari 4, 2024
IO, Merck Group, ASX, Autoimmune disease, Immune system, Death, Bladder cancer, Carcinoma, Hope, IMM, PD-L1, Avelumab, Research, Cancer, Transitional cell carcinoma, Patient, Safety, Transitional epithelium

SYDNEY, AUSTRALIA, Jan. 04, 2024 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces that the first patient has been enrolled and safely dosed in the INSIGHT-005 Phase I trial. The investigator-initiated study jointly funded with Merck KGaA, Darmstadt, Germany, will evaluate eftilagimod alpha (“efti”) in combination with BAVENCIO® (avelumab) in up to 30 patients with metastatic urothelial carcinoma.

Key Points: 
  • The investigator-initiated study jointly funded with Merck KGaA, Darmstadt, Germany, will evaluate eftilagimod alpha (“efti”) in combination with BAVENCIO® (avelumab) in up to 30 patients with metastatic urothelial carcinoma.
  • Encouragingly, responses were achieved even in cancer patients with low and negative PD-L1 expression, who typically would not be expected to respond to anti-PD-(L)1 therapy.
  • Daniel Pink, as part of the investigator-initiated INSIGHT platform for studies investigating efti in different combination treatments and routes of administration.
  • For 2023, it was estimated there would be 82,290 new cases of bladder cancer and 16,710 deaths in the US alone.1