Metabolomic Profiling of Chronic Obstructive Pulmonary Disease
Retrieved on:
tisdag, augusti 3, 2021
Chronic lower respiratory diseases, Pulmonology, Health, Medicine, Chronic obstructive pulmonary disease, Obstructive lung disease, COPD: Journal of Chronic Obstructive Pulmonary Disease, Chronic condition, Global Initiative for Chronic Obstructive Lung Disease, Pulmonary disease, chronic obstructive, severe early-onset
Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by a blockage of airflow from the lungs.COPD is associated with long-term exposure to irritating gases or particulate matter, most often from cigarette smoke and environmental pollution.
Key Points:
- Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by a blockage of airflow from the lungs.COPD is associated with long-term exposure to irritating gases or particulate matter, most often from cigarette smoke and environmental pollution.
- While there is no cure, disease progression can be delayed by reducing exposure to pollutants and infections.The development of new therapies for delaying disease progression requires a better understanding of the pathogenesis of the COPD.Recent studies have implicated alterations in energy metabolism in numerous chronic diseases including COPD.
- Nonetheless, a detailed analysis of metabolites, or small molecules, generated during energy production in COPD patients is not available.
- In this study, Dr. Sun and colleagues used metabolomic profiling to investigate aerobic and anaerobic energy metabolism in COPD patients.COPD patients had a significant increase in anaerobic metabolites at rest when compared to normal subjects.Patients with higher GOLD (Global Initiative for Chronic Obstructive Lung Disease) classification levels had more severe disease, higher pyruvate and lactic acid levels, and a reduced efficiency energy supply.