Avacta to Present Pre-Clinical Data on AVA3996 at the American Association for Cancer Research Annual Meeting

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The poster describes the data and pre-clinical rationale for the further development and disease positioning of the Company’s second pre|CISION™ candidate, AVA3996, a tumour microenvironment activated proteasome inhibitor.

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Monday, March 27, 2023
Information
Tags: 
Science, Biotechnology, Research, Pharmaceutical, Oncology, Health, Medical Devices, Clinical Trials, AACR, Fiona McLaughlin, Orange County Convention Center, Therapeutic index, American Association for Cancer Research, FAP, Neoplasm, Annual general meeting, Fibroblast activation protein, alpha, Peripheral neuropathy, Poster, Toxic encephalopathy, Tumor microenvironment, Proteasome inhibitor, Biology, Disease
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EUROPE, UNITED STATES, UNITED KINGDOM, NORTH AMERICA, FLORIDA
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Organisation: 
AVACTA GROUP, AVACTA GROUP PLC
Summary
Key Points: 
  • The poster describes the data and pre-clinical rationale for the further development and disease positioning of the Company’s second pre|CISION™ candidate, AVA3996, a tumour microenvironment activated proteasome inhibitor.
  • AVA3996 utilises Avacta’s pre|CISION™ platform to improve the therapeutic index and therefore utility of proteasome inhibitors in tumours with high FAP levels, including both solid and haematological tumours.
  • AVA3996 has the potential to deliver efficacious levels of the proteasome inhibitor warhead directly to the tumour microenvironment while reducing systemic exposure and hence associated toxicities, such as peripheral neuropathy.
  • Attending the conference from Avacta will be Fiona McLaughlin – Chief Scientific Officer, Neil Bell – Chief Development Officer, David Jones – VP Biology and Francis Wilson – VP Chemistry.


Avacta Group plc, a life sciences company developing innovative, targeted oncology drugs and powerful diagnostics, announces it will present a poster entitled ‘AVA3996, a novel pre|CISION™ medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein-alpha (FAP-a) mediated cleavage’, at the American Association for Cancer Research (AACR) 2023 Annual Meeting, taking place at Orange County Convention Center, Orlando, Florida on 16 April.

The poster describes the data and pre-clinical rationale for the further development and disease positioning of the Company’s second pre|CISION™ candidate, AVA3996, a tumour microenvironment activated proteasome inhibitor. AVA3996 utilises Avacta’s pre|CISION™ platform to improve the therapeutic index and therefore utility of proteasome inhibitors in tumours with high FAP levels, including both solid and haematological tumours. AVA3996 has the potential to deliver efficacious levels of the proteasome inhibitor warhead directly to the tumour microenvironment while reducing systemic exposure and hence associated toxicities, such as peripheral neuropathy.

Attending the conference from Avacta will be Fiona McLaughlin – Chief Scientific Officer, Neil Bell – Chief Development Officer, David Jones – VP Biology and Francis Wilson – VP Chemistry.

Poster Presentation Title

AVA3996, a novel pre|CISION™ medicine, targeted to the tumor microenvironment via fibroblast activation protein-alpha (FAP-a) mediated cleavage

Session Category

Experimental and Molecular Therapeutics

Session Title

Targeting the Tumour Microenvironment

Session Date and Time

April 16, 2023 1:30 PM – 5:30 PM ET

Location

Orange County Convention Center, Section 20

Poster Board Number

17

Abstract Presentation Number

583

The abstract is available via the AACR annual meeting website, here: https://www.abstractsonline.com/pp8/#!/10828/presentation/2606

Copies of the poster will be available on Avacta’s website following the conference at: https://avacta.com/about/resources/posters/

Alastair Smith, Avacta Chief Executive Officer, will provide a video presentation overview for investors examining the data presented in the poster. This will be available on 17th April at https://avacta.com/investors/documents-presentations/

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