Lucence Showcases Promising Data on ctDNA and ctRNA Liquid Biopsy Assay for Lung Cancer at 2022 ASCO Annual Meeting

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Lucence strives to provide clinicians with the most clinically actionable information to impact patient care using liquid biopsy.

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Tuesday, May 31, 2022
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Research, Medical Devices, Hospitals, Other Health, Biotechnology, General Health, Pharmaceutical, Health, Science, Oncology, DNA, NGS, Gene, Doctor of Philosophy, Patient, MBBS, Health, Lung cancer, Society, PARP, BRAF, Circulating tumor DNA, Tyrosine, CtRNA, Plasma, MET, RNA, Liquid biopsy, ASCO, Large-cell lung carcinoma, NRG1, CLIA, LOH, Mutation, HRD, Chowdhury, Medical imaging, NSCLC, Neoplasm
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UNITED STATES, NORTH AMERICA, CALIFORNIA, ILLINOIS, CHICAGO, SINGAPORE
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LUCENCE, LIQUIDHALLMARK CTDNA AND CTRNA
Summary
Key Points: 
  • Lucence strives to provide clinicians with the most clinically actionable information to impact patient care using liquid biopsy.
  • The data we are presenting at 2022 ASCO shows how a total nucleic acid approach combining ctDNA and ctRNA in one liquid biopsy assay could dramatically increase actionable molecular information in lung cancer patients, said Min-Han Tan, PhD, MBBS, Founding CEO of Lucence.
  • In plasma samples from non-small cell lung cancer (NSCLC) patients that were either baseline driver-negative (by ctDNA) or treated with tyrosine kinase-inhibitors, the combined assay found 8.7% (9/103) more actionable fusions than ctDNA alone.
  • The data support combining ctRNA with ctDNA in liquid biopsy to increase the total actionable diagnostic information in NSCLC patients where tissue samples are lacking, especially for gene fusions not amenable to detection in ctDNA.


Lucence, the precision oncology company pioneering ultrasensitive liquid biopsy tests using circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA), will present promising new data on the extension of its amplicon-based next generation sequencing (NGS) assays to new applications at the 58th Annual Meeting of the American Society of Clinical Oncology in-person in Chicago, from June 3rd to June 7th, 2022.

“Lucence strives to provide clinicians with the most clinically actionable information to impact patient care using liquid biopsy. The data we are presenting at 2022 ASCO shows how a total nucleic acid approach combining ctDNA and ctRNA in one liquid biopsy assay could dramatically increase actionable molecular information in lung cancer patients,” said Min-Han Tan, PhD, MBBS, Founding CEO of Lucence.

In an abstract to be presented (#3040) as part of the conference poster sessions, Lucence CTO Yukti Choudhury and collaborators examined combining an amplicon-based NGS ctRNA assay with a ctDNA assay for enhanced detection of clinically actionable gene fusions in lung cancer when compared with ctDNA alone. In plasma samples from non-small cell lung cancer (NSCLC) patients that were either baseline driver-negative (by ctDNA) or treated with tyrosine kinase-inhibitors, the combined assay found 8.7% (9/103) more actionable fusions than ctDNA alone. Together ctRNA and ctDNA resulted in detection of 30 fusions compared to 21 when only ctDNA was tested, representing a 42.8% (9/21) increase in fusion-specific detection of the combined assay; additional fusions detected included BRAF, MET and NRG1 fusions. The data support combining ctRNA with ctDNA in liquid biopsy to increase the total actionable diagnostic information in NSCLC patients where tissue samples are lacking, especially for gene fusions not amenable to detection in ctDNA.

Lucence Research Scientist Jonathan Poh and collaborators will present data (#3042) showing that ctDNA can be utilized to non-invasively assess loss of heterozygosity (LOH) in multiple cancer types. LOH is a key biomarker to identify homologous recombination deficiency (HRD) status and predict response to PARP inhibitors. Using this approach, Poh et al. showed concordance of HRD status with an orthogonal test at 91.3%. Even in the absence of pathogenic HR gene alterations, LOH detection in ctDNA provided additional diagnostic yield of HRD+ status in multiple cancer types.

In another abstract authored by Choudhury and collaborators (#3041), analysis showed that it was possible to derive meaningful ctDNA fragment size information from a multiplexed amplicon-based assay. Several groups have shown analyzing ctDNA fragment size and ratios might be used to identify and characterize early stage cancers. Choudhury hopes to extend these so-called “fragmentomics” signatures to LiquidHALLMARK.

Lucence will be exhibiting at booth 16112 at the ASCO Annual Meeting. For the latest information on Lucence at 2022 ASCO, please visit https://www.lucence.com/asco/.

Poster Presentation Details

Yukti Choudhury, et al. A cell-free RNA-based next-generation sequencing (NGS) assay for the detection of actionable gene fusions in non-small cell lung cancer (NSCLC) patients

Poster Session: Sunday, June 5th from 8am-11am CDT

Jonathan Poh, et al. Detection of homologous recombination deficiency (HRD) in cell-free DNA (cfDNA) using an amplicon-based next-generation sequencing (NGS) assay

Poster Session: Sunday, June 5th from 8am-11am CDT

Yukti Choudhury, et al. Early detection of cancer using cell-free DNA (cfDNA) size analysis on a multiplexed amplicon-based next-generation sequencing (NGS) platform

Poster Session: Sunday, June 5th from 8am-11am CDT

About Lucence

Lucence is a precision oncology company committed to bringing clarity to cancer care. Lucence makes ultrasensitive liquid biopsy tests to provide doctors and their patients life-changing information to enable earlier detection and effective treatment. Headquartered in Palo Alto, Lucence supplies personalized cancer care services through twin CLIA-licensed laboratories in the United States and Singapore. For more information, visit www.lucence.com.

About LiquidHALLMARK ctDNA and ctRNA

LiquidHALLMARK ctDNA and ctRNA panel combines ctRNA profiling of 27 actionable and emerging fusions with ctDNA profiling of mutations in 80 genes, fusions in 10 genes, and somatic variants in 15 cancer types. LiquidHALLMARK is powered by AmpliMark, the Company’s proprietary amplicon-based sequencing technology, which uses a unique molecular barcode and error-correction technology to ensure test sensitivity across multiple mutation types for single nucleotide variants and fusion genes.

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